ID A0A3Q1LRQ6_BOVIN Unreviewed; 510 AA.
AC A0A3Q1LRQ6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Tripartite motif containing 46 {ECO:0000313|Ensembl:ENSBTAP00000057745.1};
GN Name=TRIM46 {ECO:0000313|Ensembl:ENSBTAP00000057745.1,
GN ECO:0000313|VGNC:VGNC:36338};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000057745.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000057745.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000057745.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000057745.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000057745.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR AlphaFoldDB; A0A3Q1LRQ6; -.
DR Ensembl; ENSBTAT00000074099.1; ENSBTAP00000057745.1; ENSBTAG00000010622.4.
DR VEuPathDB; HostDB:ENSBTAG00000010622; -.
DR VGNC; VGNC:36338; TRIM46.
DR GeneTree; ENSGT00940000158021; -.
DR Proteomes; UP000009136; Chromosome 3.
DR Bgee; ENSBTAG00000010622; Expressed in Ammon's horn and 38 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1LRQ6; baseline.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd19786; Bbox2_TRIM46_C-I; 1.
DR CDD; cd16757; RING-HC_TRIM46_C-I; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 4.10.830.40; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR017903; COS_domain.
DR InterPro; IPR040859; Midline-1_COS.
DR InterPro; IPR027370; Znf-RING_euk.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR24099; E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED; 1.
DR PANTHER; PTHR24099:SF20; TRIPARTITE MOTIF-CONTAINING PROTEIN 46; 1.
DR Pfam; PF18568; COS; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR Pfam; PF13445; zf-RING_UBOX; 1.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51262; COS; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT DOMAIN 268..309
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 416..473
FT /note="COS"
FT /evidence="ECO:0000259|PROSITE:PS51262"
FT REGION 113..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 487..510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..138
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 510 AA; 55630 MW; D3302BFACC4B1BB8 CRC64;
MLVPGACAVT SHPHPSPHPH PAPALSPGFA AAAGIGHPGA GGHARAMAEG EDMQTFTSIM
DALVRISTSM KNMEKELLCP VCQEMYKQPL VLPCTHNVCQ ACAREVLGQQ GYIGHGGDPS
SEPTSPASTP STRSPRLSRR TLPKPDRLDR LLKSGFGTYP GRKRGALHPQ VIMFPCPACQ
GDVELGERGL AGLFRNLTLE RVVERYRQSV SVGGAILCQL CKPPQLEATK GCTECRATFC
NECFKLFHPW GTQKAQHEPT LPTLSFRPKG LMCPDHKEEV THYCKTCQRL VCQLCRVRRT
HSGHKITPVV SAYQALKDKL TKSLTYILGN QDTVQTQICE LEETVRHTEV SGQQAKEEVS
QLVRGLGAVL EEKRASLLQA IEECQQERLA RLSAQIQEHR SLLDGSGLVG YAQEVLKETD
QPCFVQAAKQ LHNRIARATE ALQTFRPAAS SSFRHCQLDV GREMKLLTEL NFLRGCGHRG
LCSGAPQASQ RPCPGGPAPS ARSPALPCHS
//
