ID A0A3Q1LSU3_BOVIN Unreviewed; 697 AA.
AC A0A3Q1LSU3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=RAS guanyl releasing protein 3 {ECO:0000313|Ensembl:ENSBTAP00000063477.1};
GN Name=RASGRP3 {ECO:0000313|Ensembl:ENSBTAP00000063477.1,
GN ECO:0000313|VGNC:VGNC:33749};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000063477.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000063477.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000063477.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000063477.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000063477.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RASGRP family.
CC {ECO:0000256|ARBA:ARBA00009566}.
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DR AlphaFoldDB; A0A3Q1LSU3; -.
DR SMR; A0A3Q1LSU3; -.
DR STRING; 9913.ENSBTAP00000063477; -.
DR Ensembl; ENSBTAT00000068365.1; ENSBTAP00000063477.1; ENSBTAG00000008006.6.
DR VEuPathDB; HostDB:ENSBTAG00000008006; -.
DR VGNC; VGNC:33749; RASGRP3.
DR GeneTree; ENSGT00940000158843; -.
DR InParanoid; A0A3Q1LSU3; -.
DR OMA; QNRVTHR; -.
DR Reactome; R-BTA-1169092; Activation of RAS in B cells.
DR Reactome; R-BTA-5673001; RAF/MAP kinase cascade.
DR Proteomes; UP000009136; Chromosome 11.
DR Bgee; ENSBTAG00000008006; Expressed in nasopharynx and 106 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1LSU3; baseline and differential.
DR GO; GO:0032045; C:guanyl-nucleotide exchange factor complex; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:Ensembl.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0019900; F:kinase binding; IEA:Ensembl.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR GO; GO:0007265; P:Ras protein signal transduction; IBA:GO_Central.
DR CDD; cd20862; C1_RASGRP3; 1.
DR CDD; cd00051; EFh; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR020454; DAG/PE-bd.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF178; RAS GUANYL-RELEASING PROTEIN 3; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF00617; RasGEF; 1.
DR PRINTS; PR00008; DAGPEDOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00054; EFh; 2.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 3..120
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 147..378
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT DOMAIN 414..449
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 452..478
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 488..538
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT REGION 600..622
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 646..697
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 600..615
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 697 AA; 78788 MW; B74927AD354AA082 CRC64;
MGSSGLGKAA TLDELLSTCI EMFDDNGELN NSYLPRIVLL MHRWYLSSTE LCTYRNASGE
SCDEFRLKIC YFMRYWIVKF PAEFNLDLGL IRMTEEFREV ASQLGYEKHT SLIDISSIPS
YDWMRRVTQR KKVSKKGKAC LLFDHLEPIE LAEHLTFLEH KSFRRISFTD YQSYVIHGCL
ENNPTLERSI ALFNGISKWV QLMVLSKPTP QQRAEVITKF INVAKKLLQL KNFNTLMAVV
GGLSHSSISR LKETHSHLSS EVTKNWNEMM ELVSSNGNYC NYRKAFADCD GFKIPILGVH
LKDLIAVHVI FPDWTEENKV NIVKMHQLSV TLSELVSLQN ASHHLEPNLD LINLLTLSLD
LYHTEDDIYK LSLVLEPRNS KSPTSPTTPT KPVVPLEWAS GVMPKPDPTV INKHIRKLVE
SVFRNYDHDH DGYISQEDFE SIAANFPFLD SFCVLDKDQD GLISKDEMMA YFLRAKSQLH
CKMGPGFVHN FQEMTYLKPT FCEHCAGFLW GIIKQGYKCK DCGANCHKQC KDLLVLACRR
FARAPSLGSS HGSLPGSPSL PPVQDEVFEF PGVTAGHRDL DSRAITLVTG SSGKISVRLQ
RATTSQATQT EPVWSEAGWG DSGSHTFPKM RSKFHDKAAK DKGFAKWENE KPRVQAGVDV
VDRGTTFEPD QDEADMDETK QDGEFADGGE LETLAPT
//
