ID A0A3Q1LTT1_BOVIN Unreviewed; 345 AA.
AC A0A3Q1LTT1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=CYFIP related Rac1 interactor B {ECO:0000313|Ensembl:ENSBTAP00000060754.1};
GN Name=CYRIB {ECO:0000313|Ensembl:ENSBTAP00000060754.1,
GN ECO:0000313|VGNC:VGNC:28819};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000060754.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000060754.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000060754.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000060754.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000060754.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Interacts with RAC1 (GTP-bound form preferentially).
CC {ECO:0000256|ARBA:ARBA00011307}.
CC -!- SIMILARITY: Belongs to the CYRI family.
CC {ECO:0000256|ARBA:ARBA00005778}.
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DR AlphaFoldDB; A0A3Q1LTT1; -.
DR Ensembl; ENSBTAT00000072967.1; ENSBTAP00000060754.1; ENSBTAG00000020801.5.
DR VEuPathDB; HostDB:ENSBTAG00000020801; -.
DR VGNC; VGNC:28819; CYRIB.
DR GeneTree; ENSGT00390000015159; -.
DR Proteomes; UP000009136; Chromosome 14.
DR Bgee; ENSBTAG00000020801; Expressed in neutrophil and 104 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1LTT1; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0030833; P:regulation of actin filament polymerization; IEA:InterPro.
DR InterPro; IPR039789; CYRI.
DR InterPro; IPR009828; CYRIA/CYRIB_Rac1-bd.
DR PANTHER; PTHR12422:SF3; CYFIP-RELATED RAC1 INTERACTOR B; 1.
DR PANTHER; PTHR12422; UNCHARACTERIZED; 1.
DR Pfam; PF07159; CYRIA-B_Rac1-bd; 1.
PE 1: Evidence at protein level;
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A3Q1LTT1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 39..341
FT /note="CYRIA/CYRIB Rac1 binding"
FT /evidence="ECO:0000259|Pfam:PF07159"
SQ SEQUENCE 345 AA; 39365 MW; 8378B4E934051E9F CRC64;
MFFFVKGYFL FSHSCLDRYL NMGNLLKVLT CTDLEQGPNF FLDFENAQPT ESEKEIYNQV
NVVLKDAEGI LEDLQSYRGA GHEIREAIQH PADEKLQEKA WGAVVPLVGK LKKFYEFSQR
LEAALRGLLG ALTSTPYSPT QHLEREQALA KQFAEILHFT LRFDELKMTN PAIQNDFSYY
RRTLSRMRIN NVPAEGENEV NNELANRMSL FYAEATPMLK TLSDATTKFV SENKNLPIEN
TTDCLSTMAS VCRVMLETPE YRSRFTNEET VSFCLRVMVG VIILYDHVHP VGAFAKTSKI
DMKGCIKVLK DQPPNSVEGL LNALRYTTKH LNDETTSKQI KSMLQ
//
