ID A0A3Q1LU12_BOVIN Unreviewed; 1010 AA.
AC A0A3Q1LU12;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Multiple EGF like domains 11 {ECO:0000313|Ensembl:ENSBTAP00000060602.1};
GN Name=MEGF11 {ECO:0000313|Ensembl:ENSBTAP00000060602.1,
GN ECO:0000313|VGNC:VGNC:55123};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000060602.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000060602.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000060602.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000060602.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000060602.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A3Q1LU12; -.
DR Ensembl; ENSBTAT00000068641.1; ENSBTAP00000060602.1; ENSBTAG00000034140.3.
DR VEuPathDB; HostDB:ENSBTAG00000034140; -.
DR VGNC; VGNC:55123; MEGF11.
DR GeneTree; ENSGT00940000155333; -.
DR Proteomes; UP000009136; Chromosome 10.
DR Bgee; ENSBTAG00000034140; Expressed in cerebellum and 51 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 5.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR011489; EMI_domain.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR24035; MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN; 1.
DR PANTHER; PTHR24035:SF127; MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN 11; 1.
DR Pfam; PF12661; hEGF; 3.
DR Pfam; PF00053; Laminin_EGF; 6.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 16.
DR SMART; SM00180; EGF_Lam; 14.
DR PROSITE; PS00022; EGF_1; 14.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 11.
DR PROSITE; PS50027; EGF_LAM_2; 1.
DR PROSITE; PS51041; EMI; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Laminin EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00460};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..1010
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018621924"
FT TRANSMEM 815..837
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 33..110
FT /note="EMI"
FT /evidence="ECO:0000259|PROSITE:PS51041"
FT DOMAIN 152..182
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 190..225
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 233..268
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 276..311
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 319..354
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 408..443
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 451..486
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 499..529
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 580..615
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 668..703
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 716..746
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 719..760
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT REGION 975..1010
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 172..181
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 215..224
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 258..267
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 301..310
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 344..353
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 433..442
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 476..485
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 519..528
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 605..614
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 693..702
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 736..745
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1010 AA; 107149 MW; 747EC599C2193ADC CRC64;
MTSSLWGPRM VLSAAGLIVG SLLQIVLSLN PEDPNVCSHW ESYAVTVQES YAHPFDQIYY
TRCTDILNWF KCTRHRISYK TAYRRGLRTM YRRRSQCCPG YYENGDFCIP LCTEECVHGR
CVSPDTCHCE PGWGGPDCSS GCDSDHWGPH CSNRCQCQNG ALCNPITGAC VCAAGFRGWR
CEELCAPGTH GKGCQLLCQC RHGASCDPQT GECLCAPGYT GVYCEELCPP GSHGAHCELR
CPCQNGGTCH HITGECACPP GWTGAVCAQP CPPGTFGQNC SQDCPCHHGG QCDHVTGQCH
CTAGYMGDRC QEECPLGTFG FQCSQRCDCH NGGQCSPTSG ACECEPGYKG PRCQERLCPE
GLHGPGCSLP CPCDADNTIS CHPVTGACTC QPGWSGYHCN ESCPVGYYGD GCQLPCTCQN
GADCHSITGS CTCAPGFMGE VCAAPCAVGT YGSNCSSVCS CNNGGTCSPV DGSCTCKEGW
QGLDCTLPCP SGTWGLNCNE SCACANGAAC SPTDGSCSCT PGWLGDTCEL PCPDGTFGLN
CSERCDCSHA DGCDPVTGHC CCLAGWTGIH CDSTCPPGRW GPNCSVSCSC ENGGSCSPED
GSCECAPGFR GPLCQRVCAP GFYGHGCTQP CPLCVHSSGP CHHVSGICEC LPGFSGALCN
QVCAGGHFGQ DCAQLCSCAN NGTCSPIDGS CQCFPGWIGK DCSQGCPAAF YGKDCGRVCQ
CQNGASCDHI SGKCTCRTGF TGEHCEQRCA PGTFGYGCQQ LCECMNNATC DHVTGTCYCS
SGFKGIRCDQ AALMMEELNP YTKISPALGA ERHSVGAVTG IVLLLFLIVV LLGLFAWRRR
RQKQKGRDLA PRVSYTPAMR MTSTDYSLSG ACGTDRRQNT YVMDKGFKDY MKESVCSSST
CSLNSSENPY ATIKDPPILT CKLPESSYEE MKSPVHRGSP YTDVPSLSTS NKNIYEVEPT
VSVVQEGRGC NSSYIQNPYD LPRNSHIPGH YDLLPVRQSP ASGPSQDKQS
//
