ID A0A3Q1LUQ9_BOVIN Unreviewed; 5922 AA.
AC A0A3Q1LUQ9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Nebulin {ECO:0000313|Ensembl:ENSBTAP00000058970.1};
GN Name=NEB {ECO:0000313|Ensembl:ENSBTAP00000058970.1,
GN ECO:0000313|VGNC:VGNC:31977};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000058970.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000058970.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000058970.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000058970.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000058970.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSBTAT00000074766.1; ENSBTAP00000058970.1; ENSBTAG00000006907.7.
DR VEuPathDB; HostDB:ENSBTAG00000006907; -.
DR VGNC; VGNC:31977; NEB.
DR GeneTree; ENSGT00940000154533; -.
DR Proteomes; UP000009136; Chromosome 2.
DR Bgee; ENSBTAG00000006907; Expressed in longissimus muscle and 60 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1LUQ9; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR CDD; cd11933; SH3_Nebulin_C; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR013998; Nebulin-like.
DR InterPro; IPR000900; Nebulin_repeat.
DR InterPro; IPR035629; Nebulin_SH3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR11039; NEBULIN; 1.
DR PANTHER; PTHR11039:SF37; NEBULIN; 1.
DR Pfam; PF00880; Nebulin; 91.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00510; NEBULIN.
DR SMART; SM00227; NEBU; 152.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51216; NEBULIN; 105.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 5863..5922
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5787..5818
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5787..5808
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5922 AA; 685255 MW; D7EFFC02AB5C4C95 CRC64;
MPNFQTRTRF YETTTTRTSD YEQSETSRPA LAQPVPEKPV ERKRVIRKKV DPSKFMTPYI
AHSQKMQNLF STNKYKENYE KAKGKPYAIT TDTPELRRIK KVQDQLSEVK YRVDGDVAKT
ICHVDEKAKD IEHAKKVSQQ VSKVLYKQNW EDTKDKYLLP PDAPELVQAI KNTAMFSKKL
YTEDWEADKT MFYPYNDSPE LRRVAQAQKA LSDIAYKKGL AEQQTQFTSL PDPPDIEFAK
KVTNQVSKQK YKEDYENKVK GKWSETPCFE IATARMNSNN ISTKKYQEDF EHMKDQIYFM
QTETPEYKVN KQAGVAASKV WGHFLIDLDI VSVWGNFLQL LLLYIMGGKK LYKENYEKTK
AKSINYCETP KFKLDTVLHN FSSDVRKATN VLGHYIGSFE DPYQVHCLKI SAQNSDVSLK
TIVHKFKCHI PADAPQFIQH RVNAYNLSDN IYKHDWEKTK AKKFDIKVDA IPLLAAKANT
KIASDVMYKK DYEKSKGKMI GALSINDDPK MLHSLKTAKN QSDHEYRKDY EKSKTIYTAP
LDMLPLTHAK KSQAIASDVD YKHLLHNYSY PPDSVNVDLA KKAYALQSDV EYKADYNSWM
KGCGWMPFGS LEMEKAKRAS DILNEKKYRQ HPDTLKFTSI EDAPIIVQSK INQAQRSDVA
YKAKGEEVIH KYSLPADLPQ FIQAKVNAYN ISENLYKADL KDLSKKGYDL RIDAIPIKAA
KAARQAASDV QYKKDYEKAK GKMVGFQSLQ DDPKLVHYMN VAKIQSDREY KKAYEKTKTR
HNTPHDMVNI VAAKKAQDVA SNVNYKHSLH HYTYLPDAMD LELSKNMMHI QSDNVYKEDY
NNWMKGIGWI PIGSLEVEKV KKAGDALNEK KYRQHPDTLK FTSIVDSPVM VQAKQNTQQV
SDILYKAKGE DVKHKYTMSP DLPQFLQAKC NAYNLSDVSM DSANQILPLQ YKYKEAYEKA
KGKQVGFRSL QDDPKLVHYM NVAKLQSDRE YKKNYENTKT SYHTPGDMVS ITAAKMAQDV
ATNVNYKQPI HHYTYLPDAL SLEHIRNVNQ IQSDNVYKDE YNHFFKGMGW IPIGSLEVEK
VKKAGDALNE KKYRQHPDTI KFTSVPDSMG MVLAQHNTKQ LSDLNYKVEG EKVKHKYTMD
PDVPQFIQAK VNAYNMSDSH YKADWKKTLA KGYDLRPDAI PIVAAKSSRN IASDFKYKEA
YEKTKGKQIG FRSLQDDPKL VHFMNVAKMQ SDREYKKGYE ASKTKYHTPL DMLSVTAAKK
SQEVATNTNY KQPFHHYTLL PDALNVEHSR NAMQIQSDNL YKSDFTNWMK GIGWLPLESL
EVEKAKKAGE ILSEKKYRQH PEKLKFTYAM DTMEQALNKS NKLIMDKTTI HVMPDTPDIL
LSRVNQITMS DKLYKAGWEE EKKKGYDLRP DAISIKAARA SRDIASDYKY KQAYEQAKGK
QIGFRSLEDD PKLVHFMQVA KMQSDREYKK AYEKSKTSFQ TPVDMLSVVA AKKSQEVATN
ANYRNVIHTY NMLPDAMSLE LAKNMMQIQS DNQYKADYAD FMKGIGWLPL GSLEAEKNKK
AMEIISEKKY RQHPDTLKYS TLMDSMNMVL AKNNAKIMNE HLYKQAWEAD KTKVHIMPDI
PQIILAKANA INISDKLYKL SLEEAKKKGY DLRTDAIPIK AAKASRDIAS DYKYKHSYEK
ERGKMVGFRS LEDDPKLVHS MQVAKMQSDR EYKKNYEKTK TSYHTPADML SVTAAKDAQA
NITNTNYKHL IHKYILLPDA MNIQLSKNMN RIQSDNEYKQ DYNEWYKGLG WSPAGSLEVE
KAKKATEYAS DQKYRQHPSN FQFTKLNDSM DMVLAKQNAH TMNKYLYTVD WNKDKTKIHV
MPDTPDILQA KQNQTMYSQK LYKLGWEEAL KKGYDLPVDA ISVQAAKASR DIVSDFKYKQ
GYRKQIGHHI GFRSLQDDPK LVLSMNVAKM QSEREYKKDF EKWKTKFSSP VDMLGVVLAK
KCQALVSDVD YKNYLHGWTC LPDQNDVIHA KKAYDLQSEN LYKSDLEWLK GIGWSPLGSL
EAEKNKRASE IISEKKYRQP PDRNKFTSIP DAMDIVLAKT NAKNRSDILY REAWDKDKTQ
IHIMPDTPDI ILAKANLINT SDKFYRMGYE ELRKKGYDLP VDAIPIKAAK ASREIASEYK
YKEGFRMQLG HHIGARNIKD DPKMMWSMHV AKIQSDREYK KDFEKWKTKF SSPVDMLGVV
LAKKCQTLVS DIDYKNYLHQ WTCLPDQSDV IHARRAYDLQ SDNLYKSDLQ WLRGIGWLPS
GSLEDEKNKR ASQILSDHVY RQHPDQFKFS SLMDSIPMVL AKNNAITMNH RLYTEAWDKD
KTTVHIMPDT PEVLLAKQNQ INYSEKLYKL GLDEAKRKGY DMRIDAIPIR AAKASRDIAS
EFKYKEGYRR QLGHHIGARA IHDDPKMMWS MHVAKIQSDR EYKKDFEKWK TKFSSPVDML
GVVLAKKCQT LVSDIDYKNY LHQWTCLPDQ SDVIHARQAY DLQSDNVYKS DLQWLRGIGW
VPIGSLDVEK SKRASEILSD KLYRQPPDKF KFTSVTDSLE QVLAKNNAIN MNKRLYTEAW
DKDKTQVHIM PDTPEITLAR TNKVNYSENL YKLAHEEAKK KGYDLRSDAI PIVAAKASRD
IISDYKYKDG YRKQLGHHIG ARDIKDDPKM MWSMHVAKIQ SDREYKKDFE KWKTKFSSPV
DMLGVVLAKK CQTLVSDIDY KNYLHQWTCL PDQSDVIHAR QAYDLQSDNV YKSDLQWLRG
IGWVPIGSVD VVKCKRAAEI LSDNLYRQPP DTLKFTSVPD SLEQVLAKNN AINMNKRLYT
EAWDKDKTQI HIMPDTPEIM LARQNKLNYS ETLYKLANEE AKKKGYDLRS DAIPIVAAKA
SRDIISDYKY KDGYRKQLGH HIGARDIKDD PKMMWSMHVA KIQSDREYKK DFEKWKTKFS
SPVDMLGVVL AKKCQTLVSD IDYKNYLHQW TCLPDQSDVI HARRAYDLQS DNIYKSDLQW
LRGIGWVPIG SVDVVKCKRA AEILSDNLYR QRPDTLKFTS VPDSLEQVLA KNNAINMNKR
LYTEAWDKDK TQIHMMPDTP EITLARQNKI NYSENLYRQA MEEAKKEGYD LRSDAIPIVA
AKASREIASD YKYKEAYRKQ LGHHIGARAI HDDPKMMWSV HVAKMQSDRE YKKDFEKYKT
RFSSPVDMLG IVLAKKCQTL VSDVDYKHPL HEWTCLPDQN DIIHARKAYD LQSDNLYKSD
LEWLKGIGWV PIGSVEVLKA KRAGEILSDN IYRQRPDTLK FTSVTDSPEQ VLAKNNAINM
NKRLYTEAWD NDKKTIHVMP DTPEIMLAKL NRINYSDKLY KLALEESRKE GYDLRLDAIP
IQAAKASREI ASDYKYKEGY RKQLGHHIGA RNIKDDPKMM WSIHAGKLQS DLEYKKDFEK
WKTKFSSPVD MMGLVQAKKC QILVSDIDYK NLLHEWTCLP DQNDIIQARK AYDLQSDAIY
KADLEWLRGI GWVPIDSVGV EHAKRAGEIL SERKYRQPAV QLKFTSITDT PEIVLAKNNA
LNHLYTEAWD ADKTSIHVMP DTPEILLAKS NSANISHKLY TKGWDESKMK DYDLRADAIS
IKSAKASRDI ASDYKYKEAY EKHKGHHIGA RSVEDDPRIM CAMNAGRIQS EREYKKEFQK
WKTKFSSPVD MLGILLAKKC QTLVSDIDYR NYLHHWTCLP DQNDIIQARK AYDLQSDNVY
KSDLEWLRGI GWMPEGSVEM NRVKNAQDLI NERRYRTRPE ALTFTSIVDT PEVVLAKANS
LQMSEVRTIL LSGSPLVGLS LRKMPPQQSK WIVSLQRPQV MGATLRISCE VQLLLYKYKE
GYRKQLGHHV GFRTLQDDPK LVWSIHAAKI QSDREYKKDY EKSKGIHNTP LDMMSIVQAK
KCQVLVSDID YRNYLHQWMC LPDQNDVIQA KKAYELQSDA IYKADLEWLR GIGWMPEGSP
EVLRVKNAQH IFRDSVYRTP VVKLKYTSIV DTPEVVLAKS NAENISIVSQ LMISDTPLML
QSKINAVQIS NYLYKTAYEK QKGHYIGCRN AKEDPKLVWA ANVLKMQNDR LYKKAYNDHK
ARITIPVDMV SINAAKEGQA LASDVDYRQY LHQWSCFPDQ NDVIQARKAY DLQSDNVYKD
DLNWLKGIGC YVWDTPQILH AKKSYDLQSQ ILYTAAGKEN LKNYNLVTDT PLYVTALQSG
INASEVKYKE NYHQTKDKYT TVLETVDYDR IKNLKDLFSS NLYKEAWDKV KATSYILPPN
TVSLTHAKNQ KYMASHIKYR EEYEKFKALY TLPRSVEDDP NTARCLRVGK FNIDRLYRSV
YEKNKMKIHI VPDMVEMVTA KDSQKKVSEI DYRLHLHEWI CHPDLQVNSH VRKVTDQISD
IVYKDDLTWL KGIGCYVWDT PEILHAKHAY DLRNDVSLPC FLVFGCFKYA SFPVWSRGKG
RGRQVQTLSH PTVSELILTL LLQFKYKEVY EHMKAYGYTL GPNDVPFVNV RRVNNITSER
LYRQLYHKLK DKIHTTPDTP EIRQVKKTQE AVSELIYKSD FFKMQGHMIS LPYTPQVLHC
RYVGDITSDI KYKEDLQVLR GMGCFLYDTP DMVRSRHLRK LWVSAPHPAR KMRDKYKVVL
DTPEYRKVQE LKTHLSEVST SVTIRNKYKI QYEKMKDKYT PVPDTPILIR AKRAYWNASD
LRYKETFQKT KGKYHTVKDA LDIVYHRTVT DHISKIKYKE NYMSQLGIWR SIPDRPEHFH
HRAVTDAVSD VKYKQDLTWL KGIGCYAYDT PDFTLAEKNK TLYSKVCIYS GIMATSMQCT
PLPPESTRTE ETASRISISK KYRADYEQRK DKYHLVVDEP RHLLAKIRKY KSSAKMLLKQ
GCNEILRPDM LTALYNTYMW SQIKYRKNYE ETKDKFTSIV DTPEHLRTTK VNKQISDILY
KLEYNKAKPR GYTTIHDTPM LLHVRKVKDE VSDLKYKEVY QRTKSNCTIE PDAVHIKAAK
DAYKVNTNLD YKKKYEATKA YWKWTPDRPD FIQAAKSTLQ QSDFEYKLDR EYLKGCKLSV
TDDKDMVLAL KNSIIESDLK YKEKHVKERG SCHAVPDTPQ ILLAKTVSSL VSENKYKSYV
KKHLAQGSYT TLPETRDTIH VKEVTKNVSD TNYKKKFVKE KGKSNYSIML EPPDVKHAMD
VAKKQSNVAY KKDAKENLHY TTVADRPDIK KATQAAKQAS EVEYRAKHRK EGSHGLSMLG
RPDIEMAKKA AKLSSQVTHM GKGHGHGAAS YDTPMMRQLK KTNVLISDVQ YRENFNKEKG
KTPKYNPKDS QLYKVMKDAN TLASEVKYKA DLKKLHKPVT DMKESLIMNH VLNTSHLASS
YQYKKNYEKS KGHYHTIPDN LEQLHLKEAT ELQSIVKYKE KYEKERGKPM LDFETPTYIT
AKESQQMQSG KEYRKDYEES IKGRNLTGLE VTPALLHVKY ATKIASEKEY RKDLEESIRG
KGLSEMEDTP DMLRAKNATQ ILNEKEYKRD LELEVKGRGL NAMANETPDF LRARNATDIA
SQIKYKQSAE MEKANFTSVV DTPEIIHAQQ VKNLSSQKKY KEDAEKCMSY YETVLDTPEM
QRVRENQKNF SLLQYQYDLK NSKGKITVVQ DTPEILRVKE NQKNFSSVLY KENLGKGTPT
PITPEMERVK RNQENFSSVL YSDSFRKQIQ GKAAYVLDTP EMRRVRETQR HISTVKYHED
FEKHKGCFTP VVTDPITERV KKNTQDFSDI CYRGIQRKVV EMEQKRNDQD QETITGLRVW
RTNPGSVFDY DPAEDNIQSR SLHMINAQAQ RRSREQSRSA SGLSISGGEE KSEHSEAAHL
STYSDGGVFF SAASTGTKLP QQRSSSVATQ QTTVSSIPSH PSTAGKIFRA MYDYMAADAD
EVSFKDGDAI VNVQAIDEGW MYGTVQRTGR TGMLPANYVE AI
//
