ID A0A3Q1LV21_BOVIN Unreviewed; 602 AA.
AC A0A3Q1LV21;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Bridging integrator 1 {ECO:0000313|Ensembl:ENSBTAP00000061213.1};
GN Name=BIN1 {ECO:0000313|Ensembl:ENSBTAP00000061213.1,
GN ECO:0000313|VGNC:VGNC:26497};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000061213.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000061213.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000061213.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000061213.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000061213.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_010800102.1; XM_010801800.2.
DR AlphaFoldDB; A0A3Q1LV21; -.
DR Ensembl; ENSBTAT00000083046.1; ENSBTAP00000061213.1; ENSBTAG00000019177.7.
DR GeneID; 614576; -.
DR CTD; 274; -.
DR VEuPathDB; HostDB:ENSBTAG00000019177; -.
DR VGNC; VGNC:26497; BIN1.
DR GeneTree; ENSGT00950000182882; -.
DR OMA; QEYDYYN; -.
DR OrthoDB; 4243832at2759; -.
DR Proteomes; UP000009136; Chromosome 2.
DR Bgee; ENSBTAG00000019177; Expressed in longissimus thoracis muscle and 103 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1LV21; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0043226; C:organelle; IEA:UniProt.
DR GO; GO:0030100; P:regulation of endocytosis; IEA:InterPro.
DR CDD; cd07611; BAR_Amphiphysin_I_II; 1.
DR CDD; cd12139; SH3_Bin1; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR003005; Amphiphysin.
DR InterPro; IPR035471; Amphiphysin-2_SH3.
DR InterPro; IPR003023; Amphiphysin_2.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46514; AMPHIPHYSIN; 1.
DR PANTHER; PTHR46514:SF4; MYC BOX-DEPENDENT-INTERACTING PROTEIN 1; 1.
DR Pfam; PF03114; BAR; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR01251; AMPHIPHYSIN.
DR PRINTS; PR01253; AMPHIPHYSIN2.
DR SMART; SM00721; BAR; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51021; BAR; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 29..276
FT /note="BAR"
FT /evidence="ECO:0000259|PROSITE:PS51021"
FT DOMAIN 529..602
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 278..369
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 417..498
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 195..222
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 484..498
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 602 AA; 66237 MW; 985FC12B8FBFD531 CRC64;
MAEMGSKGVT AGKIASNVQK KLTRAQEKVL QKLGKADETK DEQFEQCVQN FNKQLTEGTR
LQKDLRTYLA SVKAMHEASK KLNECLQEVY EPDWPGRDEA SKIAENNDLL WMDYHQKLVD
QALLTMDTYL GQFPDIKSRI AKRGRKLVDY DSARHHYESL QTAKKKDEAK IAKPVSLLEK
AAPQWCQGKL QAHLVAQTNL LRNQAEEELI KAQKVFEEMN VDLQEELPSL WNSRVGFYVN
TFQSIAGLEE NFHKEMSKLN QNLNDVLISL EKQHGSNTFT VKAQPRKKTK LFSRLRRKKN
SDNVPAKGNK SPSPPPDGSP AATPEIRVNH EPEPAGAATP GATLPKSPSQ LRKGPPVPPP
PKHTPSKEVK QEQILSLFDD TFVPEISVTT PSQFEAPGPF SEQASLLDLD FDPLPPVASP
VKAPTPSGQS IPWDLWEPTE SPAGSLPSGE PSAAEGTFAV AWPSQTAEPG PAQPAEASEA
AGAQEPGETT TSEAASSSLP AVVVETFSAT VNGTVESGSG AGRLDLPPGF MFKVQAQHDY
TATDTDELQL KAGDVVLVIP FQNPEEQDEG WLMGVKESDW NQHKELEKCR GVFPENFTER
VQ
//
