ID A0A3Q1LVL3_BOVIN Unreviewed; 1715 AA.
AC A0A3Q1LVL3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Kinesin family member 1A {ECO:0000313|Ensembl:ENSBTAP00000061454.1};
GN Name=KIF1A {ECO:0000313|Ensembl:ENSBTAP00000061454.1,
GN ECO:0000313|VGNC:VGNC:30590};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000061454.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000061454.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000061454.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000061454.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000061454.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSBTAT00000081585.1; ENSBTAP00000061454.1; ENSBTAG00000011538.6.
DR VEuPathDB; HostDB:ENSBTAG00000011538; -.
DR VGNC; VGNC:30590; KIF1A.
DR GeneTree; ENSGT00940000156474; -.
DR Proteomes; UP000009136; Chromosome 3.
DR Bgee; ENSBTAG00000011538; Expressed in prefrontal cortex and 81 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1LVL3; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd22726; FHA_KIF1A; 1.
DR CDD; cd01365; KISc_KIF1A_KIF1B; 1.
DR CDD; cd01233; PH_KIFIA_KIFIB; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 6.10.250.2520; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR049779; FHA_KIF1A.
DR InterPro; IPR022164; Kinesin-like.
DR InterPro; IPR022140; Kinesin-like_KIF1-typ.
DR InterPro; IPR032405; Kinesin_assoc.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR049780; PH_KIFIA_KIFIB.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR47117:SF2; KINESIN-LIKE PROTEIN KIF1A ISOFORM X1; 1.
DR PANTHER; PTHR47117; STAR-RELATED LIPID TRANSFER PROTEIN 9; 1.
DR Pfam; PF12473; DUF3694; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF12423; KIF1B; 1.
DR Pfam; PF00225; Kinesin; 1.
DR Pfam; PF16183; Kinesin_assoc; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00240; FHA; 1.
DR SMART; SM00129; KISc; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 5..354
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT DOMAIN 525..581
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 1600..1698
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1430..1471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1546..1583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 439..466
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 637..671
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1443..1459
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 97..104
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1715 AA; 192988 MW; 780A5891BF68B366 CRC64;
MAGASVKVAV RVRPFNSREM SRESKCIIQM SGSTTTIVNP KQPKETPKSF SFDYSYWSHT
SPEDINYASQ KQVYRDIGEE MLQHAFEGYN VCIFAYGQTG AGKSYTMMGK QEKDQQGIIP
QLCEDLFSRI NDTTNDNMSY SVEVSYMEIY CERVRDLLNP KNKGNLRVRE HPLLGPYVED
LSKLAVTSYN DIQDLMDSGN KARTVAATNM NETSSRSHAV FNIIFTQKRH DAETNITTEK
VSKVSLVDLA GSERADSTGA KGTRLKEGAN INKSLTTLGK VISALAEMDS GPNKNKKKKK
TDFIPYRDSV LTWLLRENLG GNSRTAMVAA LSPADINYDE TLSTLRYADR AKQIRCNAVI
NEDPNNKLIR ELKDEVTRLR DLLYAQGLGD ITDTGTVPGG PRLTSALVGM SPSSSLSALS
SRAASVSSLH ERILFAPGSE EAIERLKETE KIIAELNETW EEKLRRTEAI RMEREALLAE
MGVAMREDGG TLGVFSPKKT PHLVNLNEDP LMSECLLYYI KDGITRVGRE DAEKRQDIVL
SGHFIKEEHC VFRSDSCGGS EAVVTLEPCE GADTYVNGKK VTEPSVLRSG NRIIMGKSHV
FRFNHPEQAR QERERTPCAE TPAEPVDWAF AQRELLEKQG IDMKQEMEQR LQELEDQYRR
EREEATYLLE QQRLDYESKL EALQKQMDSR YYPEVNEEEE EPEDEVQWTE RECELALWAF
RKWKWYQFTS LRDLLWGNAI FLKEANAISV ELKKKVQFQF VLLTDTLYSP LPPDLLPPEA
AKDRETRPFP RTIVAVEVQD QKNGATHYWT LEKLRQRLDL MREMYDRAAE VPSSIIEDCD
NVVTGGDPFY DRFPWFRLVG RAFVYLSNLL YPVPLVHRVA VVSEKGEVKG FLRVAVQAIS
ADEEAPDYGS GVRQSGTAKI SFDDQHFEKF QAESCPGVGM SRSGTSQEEL RIVEGQGQAA
DSGPSADEVN NNTCSAVTPE GLLDSPEKAA LDGPLDAALD HLGLGSTFTF RVTVLQASSI
SAEYADIFCQ FNFIHRHDEA FSTEPLKNTG RGPPLGFYHV QNIAVEVTRS FIEYIKSQPL
VFEVFGHYQQ HPFPPLCKDV LSPLRPSRRH FPRVMPLSKP VPATKLSTLT RPCPGPCHCK
YDLLVYFEIC ELEANGDYIP AVVDHRGGMP CMGTFLLHQG IQRRITVTLL HETGSHIRWK
EVRELVVGRI RNTPETDESL IDPNILSLSI LSSGYICPAQ DDRQFLDSDM PSVSFGSDTR
TFYQFEAAWD SSMHNSLLLN RVTPYREKIY MTLSAYIEME NCTQPAVVTK DFCMVFYSRD
AKLPASRSIR NLFGSGSLRA SESNRVTGVY ELSLCHVADA GSPGMQRRRR RVLDTSVAYV
RGEENLAGWR PRSDSLILDH QWELEKLSLL QEVEKTRHYL LLREKLEAAQ RPGPETLSPA
ASDGSEAHGS SSASSPLTAE ARPASLEAPS ERQRELAVKC LRLLTHSFNR EYTHSHVCVS
ASESKLSEMS VTLLRDPSMS PLGAATLTPS STCPSLVEGR YGATDLRTPQ PCSRPASPEP
EPLPEVDAKK LPSPARAAEA DKEPQRLLVP DIQEIRVSPI VSKKGYLHFL EPHTAGWAKR
FVVVRRPYAY MYNHDKDAVE RFVLNLSTAQ VEYSEDQQAM LKTPNTFAVC TEHRGILLQA
SSDKDMHDWL YAFNPLLAGT IRSKLSRRRS AQMRV
//
