ID A0A3Q1LWC6_BOVIN Unreviewed; 739 AA.
AC A0A3Q1LWC6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=AP complex subunit beta {ECO:0000256|PIRNR:PIRNR002291};
GN Name=AP4B1 {ECO:0000313|Ensembl:ENSBTAP00000064999.1,
GN ECO:0000313|VGNC:VGNC:25991};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000064999.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000064999.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000064999.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000064999.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000064999.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the adaptor complexes large subunit family.
CC {ECO:0000256|ARBA:ARBA00006613, ECO:0000256|PIRNR:PIRNR002291}.
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DR RefSeq; XP_005204158.1; XM_005204101.2.
DR RefSeq; XP_005204159.1; XM_005204102.3.
DR RefSeq; XP_005204160.1; XM_005204103.3.
DR RefSeq; XP_005204161.1; XM_005204104.3.
DR RefSeq; XP_010801462.1; XM_010803160.2.
DR RefSeq; XP_015319176.1; XM_015463690.1.
DR AlphaFoldDB; A0A3Q1LWC6; -.
DR SMR; A0A3Q1LWC6; -.
DR STRING; 9913.ENSBTAP00000064999; -.
DR PaxDb; 9913-ENSBTAP00000004711; -.
DR Ensembl; ENSBTAT00000067973.1; ENSBTAP00000064999.1; ENSBTAG00000003614.6.
DR GeneID; 512078; -.
DR CTD; 10717; -.
DR VEuPathDB; HostDB:ENSBTAG00000003614; -.
DR VGNC; VGNC:25991; AP4B1.
DR GeneTree; ENSGT00940000157025; -.
DR InParanoid; A0A3Q1LWC6; -.
DR OMA; FIQRPTR; -.
DR OrthoDB; 648032at2759; -.
DR Reactome; R-BTA-432720; Lysosome Vesicle Biogenesis.
DR Reactome; R-BTA-432722; Golgi Associated Vesicle Biogenesis.
DR Proteomes; UP000009136; Chromosome 3.
DR Bgee; ENSBTAG00000003614; Expressed in spermatocyte and 107 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1LWC6; baseline and differential.
DR GO; GO:0030131; C:clathrin adaptor complex; IEA:InterPro.
DR GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 3.30.310.10; TATA-Binding Protein; 1.
DR InterPro; IPR026739; AP_beta.
DR InterPro; IPR016342; AP_complex_bsu_1_2_4.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR015151; B-adaptin_app_sub_C.
DR InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR InterPro; IPR012295; TBP_dom_sf.
DR PANTHER; PTHR11134; ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER; 1.
DR PANTHER; PTHR11134:SF4; AP-4 COMPLEX SUBUNIT BETA-1; 1.
DR Pfam; PF01602; Adaptin_N; 1.
DR Pfam; PF09066; B2-adapt-app_C; 1.
DR PIRSF; PIRSF002291; AP_complex_beta; 1.
DR SMART; SM01020; B2-adapt-app_C; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR002291};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR002291};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR002291}.
FT DOMAIN 620..732
FT /note="Beta-adaptin appendage C-terminal subdomain"
FT /evidence="ECO:0000259|SMART:SM01020"
SQ SEQUENCE 739 AA; 82892 MW; 0961598427C60B71 CRC64;
MPYLGSEDVV KELKKALCNP HIQADRLRYR SVIQRVIRHM TQGVDMSGVF MEMVKASATV
DIVQKKLVYL YMCTYAPLKP DLALLAINTL CKDCSDPNPM VRGLALRSMC SLRMPGVQEY
IQQPILNGLR DKASYVRRVA VLGCAKMHNL HGDSEVDGAL VNELYSLLRD QDPIVVVNCL
RSLEEILKQE GGVVINKPIA HHLLNRMSKL DQWGQAEVLN FLLRYQPRSE EELFDILNLL
DSFLKSSSPG VVMGATKLFL ILAKKFPHVQ TDVLMQVKGP LLAACSSESR ELCFAALCHV
RQILHSLPGH FSSHYKKFFC SYSEPHYIKL QKVEVLCELV NDENVQQVLE ELRGYCTDVS
ADFAQAAILA IGGIARTYTD QCMQILTELL GLRQEHITTV VVQTFRDLAW LCPQCTEAVC
QALPGCEENI QDSEGKQALI WLLGVHGKRI PNAPYVLEDF IENVKSETFP AVKMELLTAV
LRLFFSRPAE CQDMLGRLLH YCIEEEKDMA VRDRGLFYYR LLLAGISEAK QILCSPKSDP
SLRLLEDQAE RPVNSWALDF NTLVPVYGKA RWATLSKCQG VEHHGPELPN TAAFPTSGPL
IPEENKESVQ ELPDSGALML IPNHQLTAEC FEKTWLSLKV AHQQVFPWQG AVHPDTLQMA
LQVVNIQTIA MSRAGTQPWK AYLSAQDDTG CLFLTELLLE PANLQMQISV KQSEARTETL
KSFISVLETV IGTIGDIKS
//
