ID A0A3Q1LWJ1_BOVIN Unreviewed; 1040 AA.
AC A0A3Q1LWJ1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Sortilin related VPS10 domain containing receptor 1 {ECO:0000313|Ensembl:ENSBTAP00000065064.1};
GN Name=SORCS1 {ECO:0000313|Ensembl:ENSBTAP00000065064.1,
GN ECO:0000313|VGNC:VGNC:35130};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000065064.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000065064.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000065064.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000065064.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000065064.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family. SORCS
CC subfamily. {ECO:0000256|ARBA:ARBA00010818}.
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DR AlphaFoldDB; A0A3Q1LWJ1; -.
DR PaxDb; 9913-ENSBTAP00000010453; -.
DR Ensembl; ENSBTAT00000068110.1; ENSBTAP00000065064.1; ENSBTAG00000007948.6.
DR VEuPathDB; HostDB:ENSBTAG00000007948; -.
DR VGNC; VGNC:35130; SORCS1.
DR GeneTree; ENSGT01030000234563; -.
DR Proteomes; UP000009136; Chromosome 26.
DR Bgee; ENSBTAG00000007948; Expressed in semen and 59 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1LWJ1; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.10.70.80; -; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 3.30.60.270; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF8; VPS10 DOMAIN-CONTAINING RECEPTOR SORCS1; 1.
DR Pfam; PF00801; PKD; 1.
DR Pfam; PF15902; Sortilin-Vps10; 1.
DR Pfam; PF15901; Sortilin_C; 1.
DR SMART; SM00602; VPS10; 1.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR SUPFAM; SSF49299; PKD domain; 1.
DR PROSITE; PS50093; PKD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 963..981
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 697..741
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
SQ SEQUENCE 1040 AA; 117262 MW; 11E85132B4D4938F CRC64;
SYASLNQAEL GQGCRQQRQP LSDAAMMGVS SGASQTTRPY LYLCSFLVIL ILTKLFDYNL
GSITESSLWR STDYGTTYEK LNDKVGLKTI LSYLYVCPTN KRKIMLLTDP EIESSLLISS
DEGATYQKYR LNFYIQSLLF HPKQEDWILA YSQDQKLYSS AEFGRRWQLI QEAVVPNRFY
WSVMGSNKEP DLVHLEARTV DGHSQYLTCR MQNCTEANRN KPFPGYIDPD SLIVQDDYVF
VQLTSGGRPH YYVSYRRNAF AQMKLPKYAL PKDMHVISTD ENQVFAAVQE WNQNDTYNLY
ISDTRGVYFT LALENVQSSR GPEGNVMIDL YEVAGIKGMF LANKKIDNQV KTFITYNKGR
DWRLLQAPDT DLRGDPVHCV LPYCSLHLHL KVSENPYTSG IIASRDTAPS IIVASGNIGS
ELSDSDISMF VSSDAGNTWR QIFEEEHSVL YLDQGGVLVA MKHTSLPIRH LWLSFDEGRS
WSKYSFTSIP LFVDGVLGEP GEETLIMTVF GHFSHRSEWQ LVKVDYKSIF DRRCAEEDYR
PWQLHSQGEA CIMGAKRIYK KRKSERKCMQ GKYAGAMESE PCVCTEADFD CDYGYERHSN
GQCLPAFWFN PSSLSKDCSL GQSYLNSTGY RKVVSNNCTD GVREQYTAKP QKCPGKAPRG
LRIVTADGKL TAEQGHNVTL MVQLEEGDVQ RTLIQVDFGD GIAVSYVNLS SMEDGIKHVY
HNVGIFRVTV QVDNSLGSDS AVLYLHVTCP LEHVHLSLPF VTTKNKEVNA TAVLWPSQVG
TLTYVWWYGN NTEPLITLEG SIAFKFTSEG MNTITVQVSA GNAILQDTKT IAVYEEFRSL
RLSFSPNLDD YNPDIPEWRR DVSRVIKKAL VEATGVPGQH ILVAVLPGLP TAAELFVLPH
QDPTGENKRP AEDLEQISEL MIHKLNQNSV HFELKPGVQV LVHAAHLTAA PLVDLTPTHS
GSAMLMLLSV VFVGLAVFVI YKFKRKIPGI NVYAQMQNEK EQEMVSRVSH PESRPYVPQT
ELRRPGQLID EKVESQLIGK
//
