ID A0A3Q1LXI8_BOVIN Unreviewed; 254 AA.
AC A0A3Q1LXI8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Transmembrane p24 trafficking protein 3 {ECO:0000313|Ensembl:ENSBTAP00000061921.1};
GN Name=TMED3 {ECO:0000313|Ensembl:ENSBTAP00000061921.1,
GN ECO:0000313|VGNC:VGNC:35936};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000061921.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000061921.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000061921.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000061921.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000061921.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004115}. Endoplasmic reticulum-Golgi
CC intermediate compartment membrane {ECO:0000256|ARBA:ARBA00004151};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004151}.
CC Golgi apparatus, cis-Golgi network membrane
CC {ECO:0000256|ARBA:ARBA00004619}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004619}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003827}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003827}.
CC -!- SIMILARITY: Belongs to the EMP24/GP25L family.
CC {ECO:0000256|ARBA:ARBA00007104, ECO:0000256|RuleBase:RU003827}.
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DR AlphaFoldDB; A0A3Q1LXI8; -.
DR SMR; A0A3Q1LXI8; -.
DR STRING; 9913.ENSBTAP00000061921; -.
DR Ensembl; ENSBTAT00000083758.1; ENSBTAP00000061921.1; ENSBTAG00000000807.6.
DR VEuPathDB; HostDB:ENSBTAG00000000807; -.
DR VGNC; VGNC:35936; TMED3.
DR GeneTree; ENSGT00940000159833; -.
DR InParanoid; A0A3Q1LXI8; -.
DR Reactome; R-BTA-6807878; COPI-mediated anterograde transport.
DR Reactome; R-BTA-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR Proteomes; UP000009136; Chromosome 21.
DR Bgee; ENSBTAG00000000807; Expressed in saliva-secreting gland and 107 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1LXI8; baseline and differential.
DR GO; GO:0030126; C:COPI vesicle coat; IBA:GO_Central.
DR GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IBA:GO_Central.
DR GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR Gene3D; 2.60.120.680; GOLD domain; 1.
DR InterPro; IPR015720; Emp24-like.
DR InterPro; IPR009038; GOLD_dom.
DR InterPro; IPR036598; GOLD_dom_sf.
DR PANTHER; PTHR22811; TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR22811:SF60; TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF01105; EMP24_GP25L; 1.
DR SMART; SM01190; EMP24_GP25L; 1.
DR SUPFAM; SSF101576; Supernatant protein factor (SPF), C-terminal domain; 1.
DR PROSITE; PS50866; GOLD; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003827};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022927}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..254
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018624955"
FT DOMAIN 39..121
FT /note="GOLD"
FT /evidence="ECO:0000259|PROSITE:PS50866"
SQ SEQUENCE 254 AA; 28654 MW; 4EF13007DC4B5A94 CRC64;
MGGVVPRSVS ALPLLLLLLL QAERPRGAEL TFELPDNAKQ CFHEEVEQGV KFSLDYQVIT
GGHYDVDCFM KDPLGNTIYS ETKKQYDSFT HKAEVKGVYQ FCFSNEFSTF SHKTVYFDFQ
VGDEPPILPD MGNRVTALTQ MESACVTIHE ALKTVIDSQK HYRLREAQDR ARAEDLNSRV
SYWSIGETIA LFVVSFSQLI WLLCPLPCGE DWALSLDFPP LSSLYLWKPG PEAALQKPHP
RGALESALEA RTGW
//
