ID A0A3Q1LYM8_BOVIN Unreviewed; 1661 AA.
AC A0A3Q1LYM8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Eukaryotic translation initiation factor 4 gamma 3 {ECO:0000313|Ensembl:ENSBTAP00000060744.1};
GN Name=EIF4G3 {ECO:0000313|Ensembl:ENSBTAP00000060744.1,
GN ECO:0000313|VGNC:VGNC:28417};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000060744.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000060744.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000060744.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000060744.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000060744.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the eukaryotic initiation factor 4G family.
CC {ECO:0000256|ARBA:ARBA00005775}.
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DR RefSeq; XP_015316358.1; XM_015460872.1.
DR RefSeq; XP_015317960.1; XM_015462474.1.
DR Ensembl; ENSBTAT00000079421.1; ENSBTAP00000060744.1; ENSBTAG00000040215.4.
DR CTD; 8672; -.
DR VEuPathDB; HostDB:ENSBTAG00000040215; -.
DR VGNC; VGNC:28417; EIF4G3.
DR GeneTree; ENSGT00940000156454; -.
DR Proteomes; UP000009136; Chromosome 2.
DR Bgee; ENSBTAG00000040215; Expressed in spermatocyte and 105 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1LYM8; baseline and differential.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR CDD; cd11559; W2_eIF4G1_like; 1.
DR Gene3D; 1.25.40.180; -; 3.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR045208; IF4G.
DR InterPro; IPR003891; Initiation_fac_eIF4g_MI.
DR InterPro; IPR003890; MIF4G-like_typ-3.
DR InterPro; IPR003307; W2_domain.
DR PANTHER; PTHR23253; EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA; 1.
DR PANTHER; PTHR23253:SF23; EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 3; 1.
DR Pfam; PF02847; MA3; 1.
DR Pfam; PF02854; MIF4G; 1.
DR Pfam; PF02020; W2; 1.
DR SMART; SM00515; eIF5C; 1.
DR SMART; SM00544; MA3; 1.
DR SMART; SM00543; MIF4G; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR PROSITE; PS51366; MI; 1.
DR PROSITE; PS51363; W2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 1297..1419
FT /note="MI"
FT /evidence="ECO:0000259|PROSITE:PS51366"
FT DOMAIN 1492..1661
FT /note="W2"
FT /evidence="ECO:0000259|PROSITE:PS51363"
FT REGION 166..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 246..269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 343..363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 448..467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 510..659
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 802..825
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 935..955
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1090..1117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1147..1166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1176..1299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..190
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..225
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 346..362
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 520..536
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 546..614
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 627..644
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1090..1104
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1176..1202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1263..1277
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1661 AA; 184657 MW; 6C846D485A92F2CB CRC64;
MNSQPQTRSP PSRTVPIHCT DNWKRRKVLE QTPVYRSLAG RGWIKYCIFF QRPQIQPPRA
TIPNSSPSIR PGAQTPTAVY QANQHIMMVN HLPMPYPVPQ GPQYCIPQYR HSGPPYVGPP
QQYPVQPPGP GPFYPGPGPG DFPSAYGTPF YPSQPVYQSA PIIVPTQQQP PPAKREKKTI
RIRDPNQGGK DITEEIMSGG GSRNPTPPIG RPTSTPTPPQ QLPSQVPEHS PVVYGTVESA
HLAASTPVTA ASDQKQEEKP KPDPVLKTPS PVLRLALSGE KKEQAGPTSE ITAVESIPEL
PLPPSPTAIS PLARSTITSP TSVALSSQPI FTTAIDDRCE LSSSKEDTIP IPSPTSCTEA
SDPLPTDEID DDICKKSCSV APNDIPLISS TNLINEMNGV NEKLPATESI VEIVKQEVLP
LTLELEILEN PPEEIKVECV PTPITPSIVP SSSPSPPAPP ASPSPTPVIV PAAATSVNTG
RGSTGVQRAF EEGENIRTCL SEDAKEIQNK VEVEADGQTE EIVDSQNLSS RKSPVPAQTA
IPAPKMWKKP KDRTRATEES LEAESEPKAE EELSGDKILE SEQDKMSQGF HPERDPSDLK
NVKTVEENGE EAEPVRNGAE SISEGEGIDA NSGSTDSSGE GVTFPFKSES WKPPDSEGKK
QYDREFLLDF QFMPACIQKP EGLPPISDVV LDKINQPKLP MRTLDPRILP RGPDFTPAFA
DFGRQAPGGR GVPVCKVQSR HGLPILEQSK APASTPLAMS HPPLKSLPLG LLNVGARRSQ
PGQRREPRKI ITVSVKEDVH LKKAENAWKP SQRRDSPAED PENIKTQELF RKVRSILNKL
TPQMFNQLMK QVSGLTVDTE ERLKGVIDLV FEKAIDEPSF SVAYANMCRC LVTLKVPMAD
KPGNTVNFRK LLLNRCQKEF EKDKADDDVF EKKQKELEAA SAPEERTRLH DELEEAKDKA
RRRSIGNIKF IGELFKLKML TEAIMHDCVV KLLKNHDEES LECLCRLLTT IGKDLDFEKA
KPRMDQYFNQ MEKIVKERKT SSRIRFMLQD VIDLRLCNWV SRRADQGPKT IEQIHKEAKI
EEQEEQRKVQ QLMTKEKRRP GVQRVDEGGW NTVQGAKNSR VLDPSKFLKI TKPTIDEKIQ
LVPKAQLGSW GKGSSGGAKA SEADALRSSA SSLNRFSALQ PPAPSGSASS TPLEFDSRRT
LTSRGSTGRE KNDKPLQPAA ARPNTFMRGG SSKDLLDNQS QEEQRREMLE TVKQLTGGMD
VERSSAEAER SRTREPVTKP EIPVTSASDK PALSEEEMER KSKSIIDEFL HINDFKEAMQ
CVEELNAQGL QHVFVRTGVE STLERSQITR DHMGQLLYQL VQSEKLSKQD FFRGFSETLE
LADDMAIDIP HIWLYLAELV TPMLKEGGIS MRQLITEFCK PLLPVGRAGI LISEILHLLC
KQMSHKKVGA LWREADLSWK DFLPEGEDVH NFLLEQKLDF LESDSSCSSE ALLKKELSAE
ELYKRLEKLI IEDKANDEQI FDWVEANLDE SQMSSPTFLR ALMTAVCKAA IIADCSTFRV
DTAVIKQRVP ILLKYLDSDT EKELQALYAL QASIVKLDQP ANLLRMFFDC LYDEEVISED
AFYKWESSKD PAEQNGKGVA LKSVTAFFTW LREAEEESED N
//
