ID A0A3Q1LZL0_BOVIN Unreviewed; 4044 AA.
AC A0A3Q1LZL0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Dynein axonemal heavy chain 8 {ECO:0000313|Ensembl:ENSBTAP00000062773.1};
GN Name=DNAH8 {ECO:0000313|Ensembl:ENSBTAP00000062773.1,
GN ECO:0000313|VGNC:VGNC:28127};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000062773.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000062773.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000062773.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000062773.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000062773.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSBTAT00000076944.1; ENSBTAP00000062773.1; ENSBTAG00000014063.6.
DR VEuPathDB; HostDB:ENSBTAG00000014063; -.
DR VGNC; VGNC:28127; DNAH8.
DR GeneTree; ENSGT00940000158992; -.
DR Proteomes; UP000009136; Chromosome 23.
DR Bgee; ENSBTAG00000014063; Expressed in spermatid and 12 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1LZL0; baseline.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46532:SF15; DYNEIN AXONEMAL HEAVY CHAIN 8; 1.
DR PANTHER; PTHR46532; MALE FERTILITY FACTOR KL5; 1.
DR Pfam; PF12774; AAA_6; 2.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 1424..1568
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1676..1829
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2002..2150
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 2628..2694
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2855..2896
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4044 AA; 464342 MW; EA29E87E8EA9FF8F CRC64;
KMMRLYVDNA APEKLKGQCV FFVRCRNDIP INTKNIQEEV LFTVLDASEG LLVGIRNMLA
NIFLPAILAT NSWGALNQSQ QGESEKQIFI ETINRYLSFL DGARISIEGT VKLKKIDSVD
FSKLHTFEDV TLAASNSETV RQLEDVLMIW YKQIEQVLIE SEQMRKEADD SGPLTELEHW
KRMSAKFNYI IEQIKGPSCK AVINVLNVAH SKLLKNWRDL DARITDTANE SKDNVRYLYT
LEKVCQPLYN YDLVSMAHGI QNLINAIRMI HSVSRYYNTS ERMTSLFIKV TNQMVTACKA
YITDGGTNHV WDQETPVVLK KIQDCIFLFK EYQASFHKTR KQILESSGEK SFEVSEMYIF
GKFEAFCKRL EKVKMITVVQ TYSTLNNSTI EGIDILAIKF KNIYQGVKKK QYDILDPRRT
EFDTDFLDFM TKINALEVSI HNFTLVKFQK LNIPCLQLEI NHTIERILQY YVAELEATKK
LYHSQKDDPP LARNMPPIAG KILWVRQLYR RISEPINYFF VSQYAEGKAV IRQYNKISYV
LVEFEVVYHT AWIREISQLQ YALQATLFVR HPETGKLLVN FDPKILEVVR ETKCMIKMKL
DVPEQAKRLL KLESKLKGDK LYLQVRWILF SFLFKKYLFI RMCWVLVGLS IEHNCPFSGS
FEEMIPARKL KNFYPGVAEH KDISKLVLLL SSSVNSLRKA VHEALQDFQK YKTLWTEDRD
VKVKVCFHCW QRSLALFYFD LFLSSPEPMK LALSIEAKAW KMLLCRYLNE EYKKKMSDMI
AFINEYLKKL SRPIRDLDDV RFAMEALSCI RDNEIQMDMT LGPIEVRNAN FDDLWRKFVT
YSSGEQLFGL PVTDYEELNL LQKLYGLYDT VMGNISGYYE ILWGDVDIEK INAELLEFQN
RCRKLPKGLK DWQAFLDLKK RIDDFSESCP LLEMMTNKAM KQRHWDRISE LTGTPFDVES
DSFCLRNIME APLLKNKDDI EDICISAIKE KDIEAKLTQV IENWTNQNLS FAAFKGKGEL
LLKGTESGEI ITLMEDSLMV LGSLLSNRYN APFKKNIQNW VYKLSTSSDI IEEWLVVQNL
WVYLEAVFVG GDIAKQLPQE AKRFQNIDKS WIKIMQRAHE NPNVISCCVG DETMGQLLPH
LHEQLEVCQK SLTGYLEKKR LLFPRFFFVS DPVLLEILGQ ASDSHTIQPH LPAVSDNINE
VTFHAKDYDR IMAVISREGE KIILDSPVMA KGPVEIWLLD LLKMQMSSLH NIIRSAFYQI
SDSGFQLLPF LNHFPAQVGL LGIQMLWTHD SEEALNNAKD DRKIMQVTNQ KFLDILNTLI
SQTTHDLSKF DRVKFETLIT IHVHQRDIFD DLVKMHIRSV TDFEWLKQSR FYFKEDLDQT
VVSITDVDFI YQNEFLGCTD RLVITPLTDR CYITLAQALG MNMGGAPAGP AGTGKTETTK
DMGRCLGKYV VVFNCSDQMD FRGLGRIFKG LAQSGSWGCF DEFNRIELPV LSVAAQQIYI
VLTARKERKK QFIFSDGDCV DLNPEFGIFL TMNPGYAGRQ ELPENLKIQF RTVAMMVPDR
QIIMRVKLAS CGFLENVILA QKFYVLYKLC EEQLTKQVTL GGVWEKVLEH TGVIDEDEPL
FLSLINDLFP GLQLDSNSYV ELQAAVTNQV QLEGLINHPP WNLKLVQLYE TSLVRHGLMT
LGPSGSGKTM VITILMKALT ECGRPHREMR MNPKAITAPQ MFGRLDTATN DWTDGIFSTL
WRKTLKAKKG ENIFLVLDGP VDAIWIENLN SVLDDNKTLT LANGDRIPMA PSCKLLFEVH
NIENASPATV SRMGMVYISS SALSWRPILQ AWLKKRTTQE NNVFLTLYDK IFEDAYTFMK
LNLNPKMQLL ECNYIVQSLN LLEGLIPSKE EGGISCVEHL HKLFVFALMW SLGALLELES
RDKLEAFMRS HESKLDLPEI PKGLTQTMYE FYVTDYGDWE HWNKKLQPYY YPTDSVPEYS
SILVPNVDNV RTNFLIDTIA KQHKAVLLTG EQGTAKTVMI KAYLKKYDPE VQLSKSLNFS
SATEPMMFQR TIESYVDKRM GSTYGPPGGR KMTVFIDDIN MPVINEWGDQ ITNEIVRQMM
EMEGMYSLDK PGDFTTIVDV QLIAAMIHPG GGRNDIPQRL KRQFTVFNCT LPSNASIDKI
FGVIGCGYFD ACRRFKPEIC EMILNLVSAS RMLWQWTKVK MLPTPSKFHY IFNLRDLSRI
WQGMLTIKAD ECASVHVLLS LFKHECNRVI ADRFITPDDE QWFNTQLVRS VEENVSPDVG
SYILPEPYFV DFLREMPEPT GDEPEDTAFE VPKVYELVPS FEFLSEKLQF YQRQFNEIIR
GTSLDLVFFK DAMTHLIKIS RIIRTSCGNA LLVGVGGSGK QSLSRLASFI AGYQIFQITL
TRSYNVSNLT DDLKGLYKVA GADGKGITFI FTDNEIKDEA FLEYLNNLLS SGEISNLFAR
DEMDEITQGL ISVMKRELPR HPPTFDNLYE YFISRSRKNL HVVLCFSPVG EKFRARSLKF
PGLISGCTMD WFSRWPREAL VAVASYFVSG YSIVCSSDTK RQVVETMGLF HDMVSESCES
YFQRYRRRAH VTPKSYLSFI NGYKNIYTEK VKYINEQAER MNIGLDKLME ASESVAKLSQ
DLAVKEKELA VASVKADEVL AEVTVSAQAS AKVKNEVQEV KDKAQKIVDE IDSEKVIAET
KLEAARPALE EAEAALNTIK PNDIATVRKL AKPPHLIMRI MDCVLLLFQK KIDPVTMDPE
KPCCKPSWGE SLKLMSATGF LWSLQQFPKD TINEETVELL QPYFNMDDYT FESAKKVCGN
VAGLLSWTLA MATFYGVNRE VLPLKANLAK QEGRLAVANA ELGKAQALLD EKQAELDKVQ
AKFDAAMNEK MDLLNDADMC RKKMQAASTL IDGLSGEKVR WTQQSKEFRA QINRLVGDIL
LCTGFLSYLG PFNQIFRNYL LKEQWEIELK ARKIPFTENL NLISMLVDPP TIGEWGLQGL
PGDDLSIQNG IIVTKATRYP LLIDPQTQGK TWIKSKEKEN DLQVTSLNHK YFRTHLEDSL
SLGRPLLIED IREELDPALD NVLEKNFIKS GTTFKVKVGD KECDVMDTFK LYITTKLPNP
AFTPEINAKT SVIDFTVTMK GLENQLLRRV ILTEKQELES ERVKLLEDVT FNKRKMKELE
DNLLYKLSAT KGSLVDDESL IGVLRTTKLT AAEVSEKLHV AAETEVKINT AQEEFRPAAT
RGSILYFLIT EMSMVNIMYQ TSLAQFLKLF DQSMARSEKS PLPQKRITNI IEYLTYEVFT
YSVRGLYENH KFLFVLLMTL KIDLQRGTVK HREFQALIKG GAALDLKACP PKPFRWILDM
TWLNLVELSK LPQFAEIMNQ ISRNEKGWKS WFDKDAPEEE IIPDGYNDSL DTCRKLLLIR
SWCPDRTVFQ ARKYIADSLE EKYTEPVILN LEKTWEESDT RTPLICFLSM GSDPTIQIDA
LAKKLKLECR TISMGQGQEV HARKLIQMSM QQGGWVLLQN CHLGLEFMEE LLETLTITET
IDDTFRVWIT TEPHIRFPIT LLQTSLKFTN EPPQGVRAGL KRTFAGINQD LLDISNLPMW
KPMLYTVAFL HSTVQERRKF GPLGWNIPYE FNSADFSASV QFIQNHLDEC DIKKGVSWNT
VRYMIGEVQY GGRVTDDFDK RLLNCFARVW FSEKMFEPSF CFYTGYKIPV CKTLDQYFEY
IQSLPSLDNP EVFGLHPNAD ITYQSNTASA VLETITNIQP KESGGGVGET REAIVYRLSE
DMLSKLPPDY VPHEVKARLI KMGHLNSMNI FLRQEIDRMQ KVISILRSSL NDLKLAIEGT
IIMSENLRDA LDNMYDARIP QIWKRVSWDS STLGFWFTEL LERNAQFSTW IFEGRPNVFW
MTGFFNPQGF LTAMRQEVTR AHKGWALDSV TIHNEVLRQT KEEVTSPPAE GVYIYGLYMD
GAAWDRRNGK LTESTPKVLF TQLPVLHIFA INSTAPKDPK LYVCPIYKKP RRTDLTFITV
VYLRTVLSPD HWILRGVALL CDIK
//
