ID A0A3Q1LZM7_BOVIN Unreviewed; 667 AA.
AC A0A3Q1LZM7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Delta-like protein {ECO:0000256|RuleBase:RU280815};
GN Name=DLL4 {ECO:0000313|Ensembl:ENSBTAP00000061168.1,
GN ECO:0000313|VGNC:VGNC:28096};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000061168.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000061168.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000061168.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000061168.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000061168.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Putative Notch ligand involved in the mediation of Notch
CC signaling. {ECO:0000256|RuleBase:RU280815}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU280815}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU280815}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A3Q1LZM7; -.
DR Ensembl; ENSBTAT00000085148.1; ENSBTAP00000061168.1; ENSBTAG00000010361.4.
DR VEuPathDB; HostDB:ENSBTAG00000010361; -.
DR VGNC; VGNC:28096; DLL4.
DR GeneTree; ENSGT00940000157441; -.
DR Proteomes; UP000009136; Chromosome 10.
DR Bgee; ENSBTAG00000010361; Expressed in bone marrow and 100 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1LZM7; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 3.
DR Gene3D; 2.10.25.140; -; 1.
DR Gene3D; 2.60.40.3510; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 6.
DR InterPro; IPR001774; DSL.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR011651; Notch_ligand_N.
DR PANTHER; PTHR24044:SF320; DELTA-LIKE PROTEIN 4-RELATED; 1.
DR PANTHER; PTHR24044; NOTCH LIGAND FAMILY MEMBER; 1.
DR Pfam; PF01414; DSL; 1.
DR Pfam; PF00008; EGF; 2.
DR Pfam; PF12661; hEGF; 2.
DR Pfam; PF21795; JAG1-like_EGF2; 1.
DR Pfam; PF07657; MNNL; 1.
DR PRINTS; PR00010; EGFBLOOD.
DR SMART; SM00051; DSL; 1.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00179; EGF_CA; 5.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS51051; DSL; 1.
DR PROSITE; PS00022; EGF_1; 7.
DR PROSITE; PS01186; EGF_2; 5.
DR PROSITE; PS50026; EGF_3; 6.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU280815};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU280815};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU280815};
KW Transmembrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|RuleBase:RU280815,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..667
FT /note="Delta-like protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018618573"
FT TRANSMEM 492..517
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 159..203
FT /note="DSL"
FT /evidence="ECO:0000259|PROSITE:PS51051"
FT DOMAIN 204..237
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 287..325
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 327..365
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 367..403
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 405..441
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 445..483
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 161..170
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 174..186
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 194..203
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 227..236
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 315..324
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 336..353
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 355..364
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 393..402
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 431..440
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 454..471
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 473..482
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 667 AA; 72487 MW; 1D7D3800843E7350 CRC64;
MAVASRRASG WALLLLVALW QQPAAGSGVF QLQLQEFANE RGVLASGRPC EPGCRTFFRV
CLKHFQAVVS PGPCTFGSVS TPVLGTNSFA VGDNSSGGGR NPLQLPFNFT WPVSTALEAL
PPDALISKIA IQGSLAVGQN WLLDEQTSPL TRLRYSYRVI CSDNYYGDSC SRLCKKRNDH
FGHYVCQPDG SLSCLPGWTG EYCEQPICLS GCHEQNGYCS KPAECICRPG WQGRLCNECI
PHNGCRHGTC STPWQCTCDE GWGGLFCDQG ESGALARWYP GIPTPGAMNP CSPWFDFGPF
MLSFQDQEDG YHCLCPPGYY GLHCEHSTLS CADSPCFNGG SCRERNQGTS YACECPPNFT
GSNCEKKVDR CTSNPCANGG QCLNRGPNRV CRCRPGFTGA HCEINISDCA RSPCVHGGTC
HDLENGFVCT CPAGFSGRRC EVRMPAEACA SGPCFNGATC YPGLPPDNFV CNCPYGFVGS
RCEFRMSMPP TFPWVAVSLG VGLVVVLVLL CMVAVAVRQL RLRRPDGGSR EAMNNLSDFQ
KDNLIPTAQL KNTNQKKELE VDCGLDKSNC GKQQNHTLDY NLAPGLLGRG ILPGKYSHSD
KSLGEKAPLR IHSEKPECRI SAICSPRDSM YQSVCLISEE RNECVIATEV SDGPAFPSRM
CPPTFRE
//
