ID A0A3Q1M023_BOVIN Unreviewed; 651 AA.
AC A0A3Q1M023;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Rac GTPase activating protein 1 {ECO:0000313|Ensembl:ENSBTAP00000063279.1};
GN Name=RACGAP1 {ECO:0000313|Ensembl:ENSBTAP00000063279.1,
GN ECO:0000313|VGNC:VGNC:33675};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000063279.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000063279.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000063279.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000063279.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000063279.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3Q1M023; -.
DR PaxDb; 9913-ENSBTAP00000016988; -.
DR Ensembl; ENSBTAT00000070704.1; ENSBTAP00000063279.1; ENSBTAG00000012784.6.
DR VEuPathDB; HostDB:ENSBTAG00000012784; -.
DR VGNC; VGNC:33675; RACGAP1.
DR GeneTree; ENSGT00940000154610; -.
DR Proteomes; UP000009136; Chromosome 5.
DR Bgee; ENSBTAG00000012784; Expressed in oocyte and 106 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1M023; baseline and differential.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd20821; C1_MgcRacGAP; 1.
DR CDD; cd04382; RhoGAP_MgcRacGAP; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR46199; RAC GTPASE-ACTIVATING PROTEIN 1; 1.
DR PANTHER; PTHR46199:SF1; RAC GTPASE-ACTIVATING PROTEIN 1; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 305..354
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 368..558
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 201..249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 264..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 600..651
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 77..125
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 222..240
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 602..643
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 651 AA; 72940 MW; 988EB3B001D90B1D CRC64;
MKPPCSPGCL SFWSSLLRKM DTTMLNMRNL FEQLVRRVEI LSEGNELQFI QLAKDFEDFR
KKWQRTDHEL GKYKDLLMKA ETERSALDVK LKHARNQVDV EIKRRQRAEA DCEKLERQIQ
LIREMLMCDT SGSIQLSEEQ KSALAFLNRG QPASGNAGNK RLSTIDESGS ILSDISFDKT
DESLDWDSSL VKTFKLKKRE KRRSNSRQFV DGPPGPVKKT RSIGSTADQG NESIVAKTTV
TVPNDGGPIE AVSTIETVPY WTRSRRKTGT LQPWNSDSTL SSRQPEPKTE TDGSSTPQSN
GGMRLHDFVS KTVIKPESCV PCGKRIKFGK PSLKCRDCRV VSHPECRDRC PLPCIPTLIG
TPVKIGDGML ADYVSQTSPM IPSIVVHCVN EIEQRGLTET GLYRISGCDR TVKELKEKFL
RVKTVPLLSK VDDIHAICSL LKDFLRNLKE PLLTFRLNKT FMDAAEITDD DNSIAAMYQA
VGELPQANRD TLAFLMIHLQ RVAQSPNTKM DVANLAKVFG PTIVGHAVSN PDPVTLLQDI
KHQPKVVERL LSLPLEYWSQ FMMVEQENID PMHVIENANA FSTPQTPDVK VSLLGPVTTP
EHQLLKTPSS SSLSQRVRST LTRNTPRFGS KSKSATNLGR QGNFFASPML K
//
