ID A0A3Q1M0Y5_BOVIN Unreviewed; 1174 AA.
AC A0A3Q1M0Y5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Transient receptor potential cation channel subfamily M member 5 {ECO:0000313|Ensembl:ENSBTAP00000066902.1};
GN Name=TRPM5 {ECO:0000313|Ensembl:ENSBTAP00000066902.1,
GN ECO:0000313|VGNC:VGNC:36391};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000066902.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000066902.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000066902.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000066902.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000066902.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A3Q1M0Y5; -.
DR SMR; A0A3Q1M0Y5; -.
DR STRING; 9913.ENSBTAP00000066902; -.
DR Ensembl; ENSBTAT00000075032.1; ENSBTAP00000066902.1; ENSBTAG00000046662.2.
DR VEuPathDB; HostDB:ENSBTAG00000046662; -.
DR VGNC; VGNC:36391; TRPM5.
DR GeneTree; ENSGT00940000160588; -.
DR InParanoid; A0A3Q1M0Y5; -.
DR OMA; CYCTAVI; -.
DR Reactome; R-BTA-3295583; TRP channels.
DR Proteomes; UP000009136; Chromosome 29.
DR Bgee; ENSBTAG00000046662; Expressed in adult mammalian kidney and 35 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1M0Y5; baseline.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IBA:GO_Central.
DR GO; GO:0099604; F:ligand-gated calcium channel activity; IBA:GO_Central.
DR GO; GO:0005267; F:potassium channel activity; IEA:Ensembl.
DR GO; GO:0005272; F:sodium channel activity; IEA:Ensembl.
DR GO; GO:0070588; P:calcium ion transmembrane transport; IBA:GO_Central.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR041491; TRPM_SLOG.
DR PANTHER; PTHR13800:SF5; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 5; 1.
DR PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF18139; LSDAT_euk; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023303}.
FT TRANSMEM 644..664
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 724..746
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 766..786
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 807..828
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 834..851
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 871..892
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 947..967
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 39..269
FT /note="TRPM SLOG"
FT /evidence="ECO:0000259|Pfam:PF18139"
FT DOMAIN 739..983
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1126..1174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1053..1105
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1155..1174
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1174 AA; 131761 MW; D1B94D47A3966219 CRC64;
MQDAGGTRPG SPRGAGDTWE PSLGRGEIIF GRSGKKRGKF VRVPSGVAPS VLFDLLLAEW
HLPAPNLVVS LVGEERPFAL KPWLRDVLRK GLVKAAQSTG AWILTSALRV GLARYVGQAV
RDHSLASTST KARVVAIGIA SLGRVLHRRL LDHAQGDGPV HYPLDDGGSQ GPFCPLDNNH
SHFILVEPGS PGKGDGPTEL RLRLEKYISE QRTGYGGTSS IEIPVLCLLV NGDPSTLERI
SRAVEHAAPW LILAGSGGIA DVLAALMNQP HLLTPQVAEK QFREKFPSEH FSWEDVVRWT
GLLQTIMSHR HLLTVHDFEQ EGSEELDTVI LKALVKACKS HSQEAQDYLD ELKLAVAWDR
VDIAKSEIFN GDVEWKSRDL EEVMMDALVS NKPEFVRLFV DNGADVADFL TYGRLQQLYR
SVAPKSLLFD LLQRKHEEGR LTLAGLGAQQ AREPPAGPPA FSLHEVSRVL KDFLHDACRG
LYQADTPALQ ERGLARRPSG QKGLLDLNQR SEDPWRDLFL WAVLQNRHEM ATYFWAMGQE
GVAAALAACK ILKEMSHLET EAEVGRTLRE AKYEQLALDL FSQCYRHSEE RAFALLVRRN
RCWSRTTCLH LATEADSKAF FAHDGVQAFL TKIWWGDMAS GTPILRLLGA FFCPALIYTN
LIAFSKEAPL RTGPEDLQEL DSLDTEKSLL CGLGSRAEEL SEALRSERDR GRRAAFLLTR
WRKFWGAPVT VFLGNVVMYF AFLFLFTYVL LVDFRPPPQG PSGSEVALYF WVFTLVLEEI
RQGFFTDEDT HLVKKLTLYV EDSWNKCDLV AIFLFIAGVT CRMLPWAFEA GRTVLAIDFM
VFTLRLIHIF AVHKQLGPKI IIVERMMKDV FFFLFFLSVW LVAYGVTTQA LLHPHDGRLE
WIFRRVLYRP YLQIFGQIPL DEIDEARVNC SLHPLLLEGS PSCPNLYANW VVILLLVTFL
LVTNVLLMNL LIAMFSYTFQ VVQGNADAFW KFQRFHLIVE YHERPALAPP FILLSHLSLV
LKRLLQRGTP QKRARLERDL PEPLDQKVVT WEAVQKENFL SELEKRRRES QEELLRKAAH
RVDVVAKYLG GLREQERRVR RLESQVGWWI RAPFSLGLAG GHAVRAGAGR REPGASGLVP
TPPGGDPAAP QGSCAEDPSP STPHTHAGAS SSLS
//
