ID A0A3Q1M1N2_BOVIN Unreviewed; 2352 AA.
AC A0A3Q1M1N2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Tetratricopeptide repeat domain 28 {ECO:0000313|Ensembl:ENSBTAP00000067264.1};
GN Name=TTC28 {ECO:0000313|Ensembl:ENSBTAP00000067264.1,
GN ECO:0000313|VGNC:VGNC:36467};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000067264.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000067264.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000067264.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000067264.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000067264.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSBTAT00000080699.1; ENSBTAP00000067264.1; ENSBTAG00000012193.6.
DR VEuPathDB; HostDB:ENSBTAG00000012193; -.
DR VGNC; VGNC:36467; TTC28.
DR GeneTree; ENSGT00940000156428; -.
DR Proteomes; UP000009136; Chromosome 17.
DR Bgee; ENSBTAG00000012193; Expressed in pigment epithelium of eye and 106 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1M1N2; baseline and differential.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 5.
DR InterPro; IPR024983; CHAT_dom.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR10098; RAPSYN-RELATED; 1.
DR PANTHER; PTHR10098:SF106; TETRATRICOPEPTIDE REPEAT PROTEIN 28; 1.
DR Pfam; PF12770; CHAT; 1.
DR Pfam; PF13424; TPR_12; 10.
DR Pfam; PF13176; TPR_7; 2.
DR SMART; SM00028; TPR; 23.
DR SUPFAM; SSF48452; TPR-like; 6.
DR PROSITE; PS50005; TPR; 11.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT REPEAT 8..41
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 196..229
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 236..269
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 276..309
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 396..429
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 476..509
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 516..549
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 759..792
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 839..872
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 879..912
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 959..992
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 1273..1595
FT /note="CHAT"
FT /evidence="ECO:0000259|Pfam:PF12770"
FT REGION 1878..1929
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1965..2065
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2078..2216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2236..2255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2269..2352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 852..879
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1965..2018
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2078..2157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2166..2205
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2270..2292
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2352 AA; 255929 MW; 60C120987707EBC4 CRC64;
MMKWQPRKKA YFRQGVALQY LGRHADALAA FASGLAQDPK SLQLLVGMVE AAMKSPMRDS
LEPTYQQLQK MKLDKSPFVV VSVVGQELLT AGHHGASVVV LEAALKIGTC SLKLRGSVFS
ALSSAYWSLG NTEKSTGYMQ QDLDVAKTLG DQTGECRAHG NLGSAFFSKG NYREALTNHR
HQLVLAMKLK DREAASSALS SLGHVYTAIG DYPNALASHK QCVLLAKQSK DELSEARELG
NMGAVYIAMG DFENAVQCHE QHLKIAKDLG NKREEARAYS NLGSAYHYRR NFDKAMSYHN
YVLELAQELM EKAIEMRAYA GLGHAARCMQ DLERAKQYHE QQLGIAEDLK DRAAEGRASS
NLGIIHQMKG DYDTALKLHK THLCIAQELS DYAAQGRAYG NMGNAYNALG MYDQAVKYHR
QELQISMEVN DRASQASTHG NLAVAYQALG AHDRALQHYQ NHLNIARELR DIQSEARALS
NLGNFHCSRG EYVQAAPYYE QYLRLAPDLQ DMEGEGKVCH NLGYAHYCLG NYQEAVKYYE
QDLALAKDLH DKLSQAKAYC NLGLAFKALL NFSKAEECQK YLLSLAQSLN NSQAKFRALG
NLGDIFICKK DINGAIKFYE QQLGLAHHVK DRRLEASAYA ALGTAYRMIQ KHDKALGYHT
QELEVYQELS DLPGECRAHG HLAAVYMALG KYTMAFKCYE EQLDLGQKLK DPSLEAQVYG
NMGITKMNMN VMEEAIGYFE QQLAMLQQLS GNESVLDRGR AYGNLGDCYE ALGDYEEAIK
YYEQYLSVAQ SLNRMQDQAK AYRGLGNGHR AMGSLQQALV CFEKRLVVAH ELGEAFNKAQ
AYGELGSLHS QLGNYEQAIS CLERQLNIAR EMKDRALESD AACGLGGVYQ QMGEYDTALQ
YHQLDLQIAE ETNNPTCQGR AYGNLGLTYE SLGTFERAVV YQEQHLSIAA QMNDLVAKTV
SYSSLGRTHH ALQNYSQAVM YLQEGLRLAE QLGRREDEAK IRHGLGLSLW ASGNLEEAQH
QLYRASALFE TIRHEAQLST DYKLSLFDLQ TSSYQALQRV LVSLGHHDEA LAVAERGRTR
AFADLLVERQ TGQQDSDPYS PVTIDQILEM VNGQRGLVLY YSLAAGYLYS WLLAPGAGIL
KFHEHYLGDS TVGSPSDPQT GGSAALPTAA SSALEQHVAS VREALGVESY CSRACASSET
ESEAGDIMDQ QFEEMNNRLN SVTDPTGFLR MVRRNNLFNR SCQSMTSLVG NTASPIKDGT
SSLPRRQSSF ARPPLRALYD LLVAPMEGGL MHSSGPVGRH RQLVLVLEGD LYLIPFALLK
GSSSNEYLYE RFALIAVPSI RSLSPQAKSH LRKSPPAYSS STSMAAVVGN PKLPSAVMDR
WLWGPMPSAE EEAYMVSELL GCQPLVGSVA TKERVMSALT QAECVHFATH ISWKLSALVL
TPSVDGAPAG GKSSFGHPYT IPESLRVQDD ASDGESISDC PPLQELLLTA ADILDLRLPV
KLVVLGSSQE SSSRITADGV VALTRAFLAA GAQCVLVSLW PVPVAASKMF LHALYSSLLN
GLKASAALGE AMKVVQSSKA FSHPSNWAGF MLIGSDVKLN SPSSLISQAL TEILQHPERA
RDALRVLLHL VEKSLQRIQN GQRNAMYTSQ QSVENKVGGI PGWQALLTAV GFRLDPPASG
LPAAVFFPTS DPGDRLQQCS STVQSLLGLP NPALQALCKL ITASETGEQL ISRLHQVLVQ
LQAGEKEQDF ASAPIQVSIS VQLWRLPGCH EFLAALGFDL CEVGQEEVIL KTGKQANRRT
MHFALQALLA LFDSTELPKR LSLDSSSSLE SLASAQSVSN ALPLGFQHPP FSPTGAESIA
SDAISVYSLS SIASSMSFVS KPDGGSEGAV PRGRQDYERS KNTYPPRAAL PRSPLSPPAR
PAGAKDEEEY EGFSIISTEP LAASQEDPPT GFSPDHKQSL VGTAGGVKVS VSSSTPNSPV
KMTLIPSPNS PFQKVGKLAS SDTGESDQSS TETDSTVKSQ EESNSKLDPQ ELAQKILEET
QSHLMAVERL QRGGGQGASS EDGISVPNSA AVFRASETSA FSRPALSHQK SQAALSSSPV
TIKPKPPARS SSLPKVSSGY SSPTASEASA KDSPSQHSGR PSPGSDSQTS LSDQPLFKLK
YPSSPYSAHI SKSPRNMSPS SGHQSPAGSA PSPALSYSSA GSARSSPADH PDLDKLKMAA
IDEKVQAVHN LKMFWQSTPQ HSTGPMKILR GAPGTMTSKR DVLSLLNLSP RHNKKEEGAD
KLELKELSLQ RRGETPPKAP PNGHWRTETT SLSTLPLPAR PPAPAPTRPL RLPSGNGYKF
LSPGRFFPSS KC
//
