ID A0A3Q1M1U0_BOVIN Unreviewed; 831 AA.
AC A0A3Q1M1U0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=MutS homolog 5 {ECO:0000313|Ensembl:ENSBTAP00000067333.1};
GN Name=MSH5 {ECO:0000313|Ensembl:ENSBTAP00000067333.1,
GN ECO:0000313|VGNC:VGNC:110051};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000067333.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000067333.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000067333.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000067333.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000067333.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271}.
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DR RefSeq; XP_010816607.1; XM_010818305.2.
DR RefSeq; XP_010816608.1; XM_010818306.2.
DR AlphaFoldDB; A0A3Q1M1U0; -.
DR SMR; A0A3Q1M1U0; -.
DR PaxDb; 9913-ENSBTAP00000026367; -.
DR Ensembl; ENSBTAT00000079082.1; ENSBTAP00000067333.1; ENSBTAG00000019790.5.
DR GeneID; 100139295; -.
DR CTD; 4439; -.
DR VEuPathDB; HostDB:ENSBTAG00000019790; -.
DR VGNC; VGNC:110051; MSH5.
DR GeneTree; ENSGT00550000074977; -.
DR OrthoDB; 9867at2759; -.
DR Proteomes; UP000009136; Chromosome 23.
DR Bgee; ENSBTAG00000019790; Expressed in oocyte and 93 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1M1U0; baseline.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0007127; P:meiosis I; IEA:UniProt.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd03281; ABC_MSH5_euk; 1.
DR Gene3D; 1.10.1420.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR PANTHER; PTHR11361:SF20; MUTS PROTEIN HOMOLOG 5; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF005813; MSH2; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 663..679
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 831 AA; 92474 MW; A478A370A8A223CA CRC64;
MASVAATPTR TPNGPGPGEA SASFPTVASD PGPREPEEEG EEEPAEIHLC VLWNSGYLGI
AYYDTSDSTI HFMPDAPDHE SLKLLQRVLD EIDPRSVVTS AKQDENMTRF LGKLASQEHR
EPKRPEIIFL PSVDFGLEIS KQRLLSGNYS FLPDSMTTTE KILFLSSIIP FDCLLMVRAL
GGLLKFLGRR RIGVELEDYN VSVPILGFKK FVLTNLVSID QDTYSVLQIF KSESHPSVYK
VASGLKEGLS LFGILNRCRC KWGEKLLRLW FTRPTQDLGE LNSRLDVIQF FLLPQNLDMA
QMLHRLLGHI KNVPLILKRM TLSHTKVSDW QVLYKTVYSA LGLRDACRSL PQSIQLFRDI
AQEFSDDLHH IASLIGKVVD FEGSLAENRF TVLPNIDPEI DEKKRRLMGL PSFLTEVARK
ELENLDSRIP SCSVIYIPLI GFLLSIPRLP SMVETSDFEI EGLDFMFLSE EKLHYRSART
KELDALLGDL HCDIRDQETL LMHQLQCQVL ARAAVLTRVL DLASRLDVLL ALASAARDYG
YSRPRYSPRL LGVRIQNGRH PLMELCARTF VPNSAECGGD AGRVKVITGP NSSGKSIYLK
QVGLITFMAL VGSFVPAEEA EIGAVDAIFT RIHSCESISL GLSTFMIDLN QVAKAVNNAT
ERSLVLVDEF GKGTNTVDGL ALLAAVIRHW LALGPTCPHV FVATNFLSLV QLQLLPRGPL
VQYLTMETCE DGDDLVFFYQ VCEGVARASH ASHTAAQAGL PEKLIARGKQ VSDLIRSGKP
IKPVKELLKE KQMENCQTLV DKFLKLDLED PSLDLDIFMS QEVLPAATTI L
//
