ID A0A3Q1M4R8_BOVIN Unreviewed; 652 AA.
AC A0A3Q1M4R8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Amiloride-sensitive sodium channel subunit gamma {ECO:0000256|ARBA:ARBA00039160};
DE AltName: Full=Epithelial Na(+) channel subunit gamma {ECO:0000256|ARBA:ARBA00041623};
DE AltName: Full=Gamma-NaCH {ECO:0000256|ARBA:ARBA00042229};
DE AltName: Full=Nonvoltage-gated sodium channel 1 subunit gamma {ECO:0000256|ARBA:ARBA00043111};
DE AltName: Full=SCNEG {ECO:0000256|ARBA:ARBA00041935};
GN Name=SCNN1G {ECO:0000313|Ensembl:ENSBTAP00000063259.1,
GN ECO:0000313|VGNC:VGNC:34358};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000063259.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000063259.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000063259.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000063259.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000063259.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Apical cell membrane
CC {ECO:0000256|ARBA:ARBA00004424}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004424}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. SCNN1G subfamily. {ECO:0000256|ARBA:ARBA00038067}.
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DR RefSeq; XP_005224822.1; XM_005224765.3.
DR AlphaFoldDB; A0A3Q1M4R8; -.
DR Ensembl; ENSBTAT00000079061.1; ENSBTAP00000063259.1; ENSBTAG00000010163.6.
DR VEuPathDB; HostDB:ENSBTAG00000010163; -.
DR VGNC; VGNC:34358; SCNN1G.
DR GeneTree; ENSGT00940000160352; -.
DR Proteomes; UP000009136; Chromosome 25.
DR Bgee; ENSBTAG00000010163; Expressed in adult mammalian kidney and 56 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1M4R8; baseline.
DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0034706; C:sodium channel complex; IEA:Ensembl.
DR GO; GO:0015280; F:ligand-gated sodium channel activity; IEA:Ensembl.
DR GO; GO:0050699; F:WW domain binding; IEA:Ensembl.
DR GO; GO:0071468; P:cellular response to acidic pH; IEA:Ensembl.
DR GO; GO:1904045; P:cellular response to aldosterone; IEA:Ensembl.
DR GO; GO:0006883; P:intracellular sodium ion homeostasis; IEA:Ensembl.
DR GO; GO:0050891; P:multicellular organismal-level water homeostasis; IEA:Ensembl.
DR GO; GO:0050909; P:sensory perception of taste; IEA:UniProtKB-KW.
DR GO; GO:0098719; P:sodium ion import across plasma membrane; IEA:Ensembl.
DR Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR Gene3D; 1.10.287.770; YojJ-like; 1.
DR InterPro; IPR001873; ENaC.
DR InterPro; IPR004724; ENaC_chordates.
DR InterPro; IPR020903; ENaC_CS.
DR NCBIfam; TIGR00859; ENaC; 1.
DR PANTHER; PTHR11690:SF19; AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT GAMMA; 1.
DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR Pfam; PF00858; ASC; 1.
DR PRINTS; PR01078; AMINACHANNEL.
DR PROSITE; PS01206; ASC; 1.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|ARBA:ARBA00022461};
KW Ion transport {ECO:0000256|ARBA:ARBA00022461};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Taste {ECO:0000256|ARBA:ARBA00022480};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022461}.
FT TRANSMEM 54..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 583..631
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 652 AA; 74221 MW; 22A3983C74453826 CRC64;
MAPGEKIKAK IKKNLPVTGP QAPNIKELMQ WYCLNTNTHG CRRIVVSRGR LRRLLWILFT
LTAVALIFWQ CALLISSFYT VSVSIKVHFQ KLDFPAVTIC NINPYKYSAV RHLLADLEQE
TRAALKTLYG FSEITSRKRR EAQSWSSVRK GTDPKFLNLA PLMAFEKGDT GKARDFFTGR
KRKVNARIIH KASDVMHIHN SKEVVGFQLC SNDTSDCAVY TFSSGVNAIQ EWYKLHYMNI
MAQVSQEKKI NMSYSADELL VTCFFDGVSC DARNFTLFHH PMYGNCYTFN NRQNETILST
SMGGSEFGLQ VILYINEEEY NPFLVSSTGA KVIIHRQDEY PFVEDVGTEI ETAMATSIGM
HLTESFKLSD PYSQCTEDWS DVQITNIYNA TYSLQICLHS CFQAKMVENC GCAQYSQPLP
RGADYCNYQQ HPNWMYCYYQ LHQAFVREEL GCQSVCKEAC SFKEWTLTTS LAQWPSEVSE
KWLLSILTWD QSQQIKKKLN KTDLAKLLIF YKDLNQRSIM ENPANSIEQL LSNIGGQLGL
WMSCSVVCVI EIIEVFFIDS LSIIARHQWH KAKGWWARRR APACPEAPRA PQGRDNPSLD
IDDDLPTFTS ALSLPPAPGS QVPGTPPPRY NTLRLERAFS SQLTDTQVPA ES
//
