ID A0A3Q1M4Z4_BOVIN Unreviewed; 1777 AA.
AC A0A3Q1M4Z4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Dedicator of cytokinesis 3 {ECO:0000313|Ensembl:ENSBTAP00000064911.1};
GN Name=DOCK3 {ECO:0000313|Ensembl:ENSBTAP00000064911.1,
GN ECO:0000313|VGNC:VGNC:50146};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000064911.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000064911.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000064911.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000064911.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000064911.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR Ensembl; ENSBTAT00000087176.1; ENSBTAP00000064911.1; ENSBTAG00000001874.7.
DR VEuPathDB; HostDB:ENSBTAG00000001874; -.
DR VGNC; VGNC:50146; DOCK3.
DR GeneTree; ENSGT00940000155514; -.
DR Proteomes; UP000009136; Chromosome 22.
DR Bgee; ENSBTAG00000001874; Expressed in prefrontal cortex and 83 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1M4Z4; baseline.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08695; C2_Dock-B; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.1270.350; Dedicator of cytokinesis N-terminal subdomain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037811; C2_Dock-B.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR032376; DOCK_N.
DR InterPro; IPR042455; DOCK_N_sub1.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR PANTHER; PTHR45653; DEDICATOR OF CYTOKINESIS; 1.
DR PANTHER; PTHR45653:SF4; DEDICATOR OF CYTOKINESIS PROTEIN 3; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF16172; DOCK_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..1777
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018748120"
FT DOMAIN 400..578
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1193..1600
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
SQ SEQUENCE 1777 AA; 205944 MW; E6E5111017D773D2 CRC64;
MFIFGFLVIC SFRGSVPQGL VLEIGETVQI LEKCEGKYGP INYKTQIGIF PANYIHLKKA
IVSNRGQYET VVPLEDSIVT EVTATLQEWA SLWKQLYVKH KVDLFYKLRH VMNELIDLRR
QLLSGHLTQD QVREVKRHIT VRLDWGNEHL GLDLVPRKDF EVVDSDQISV SDLYKMVDTA
RPRHGESCRI PVPHHFFLSL KSLTYNTIGE DTDVFFSLYD MREGKQISER FLVRLNKNGG
PRNPEKIERM CALFTDLSSK DMKRDLYIVA HVIRIGRMLL NDSKKGPAHL HYRRPYGCAV
LSVLDVLQSL TELKEEKDFV LKVYTCNNES EWSQIHENII RKSSAKYSAP SASHGLIISL
QLLRGDMEQI RRENPMIFNR GLAITRKLGF PDVIMPGDIR NDLYLTLEKG DFERGGKSVQ
KNIEVTMYVL YADGEILKDC ISLGSGEPNR SSYHSFVLYH SNSPRWGEII KLPIPIDRFR
GSHLRFEFRH CSTKDKGEKK LFGFAFSPLM RDDGTTLSDD IHELYVYKCD ENSTFNNHAL
YLGLPCCKED YNGCPNIPSS LIFQRSTKES FFISTQLSST KLTQNVDLLA LLKWKAFPDR
IMDILGRLRH VSGEEIVKFL QDILDTLFVI LDDNTEKYGL LVFQSLVFII NLLRDIKYFH
FRPVMDTYIQ KHFAGALAYK ELIRCLKWYM DCSAELIRQD HIQEAMRALE YLFKFIVQSR
ILYSRATCGM EEEQFRSSIQ ELFQSIRFVL SLDSRNSETL LFTQAALLNS FPTIFDELLQ
MFTVQEVAEF VRGTLGSMPS TVHIGQSMDV VKLQSIARTV DSRLFSFSES RRILLPVVLH
HIHLHLRQQK ELLICSGILG SIFSIVKTSS LVEVEMMVES LLDVLLQTLL TIMSKSHAQE
AVRGQRCPQC TAEITGEYVS CLLSLLRQMC DTHYQHLLDN FQSKDELKEF LLKIFCVFRN
LMKMSVFPRD WMVMRLLTSN IIVTTVQYLS SALHKNFTET DFDFKVWNSY FSLAVLFINQ
PSLQLEIITS TKRKKILDKY GDMRVMMAYE LFSMWQNLGE HKIHFIPGMI GPFLGVTLVP
QPEVRNIMIP IFHDMMDWEQ RKNGNFKQVE AELIDKLDSM VSEGKGDESY RELFGLLTQL
FGPYPSLLEK VEQETWRETG ISFVTSVTRL MERLLDYRYL LRNLPDLFSG HMLSPINKEE
MYIRYIHKLC DMHLQAENYT EAAFTLLLYC ELLQWEERPL REFLHYPSQT EWQRKEGLCR
KIIHYFNKGK SWEFGIPLCR ELACQYESLY DYQSLSWIRK MEASYYDNIM EQQRLEPEFF
RVGFYGRKFP FFLRNKEYVC RGHDYERLEA FQQRMLSEFP QAVAMQHPNH PDDAILQCDA
QYLQIYAVTP IPEYVDVLQM DRVPDRVKSF YRVNNVRRFR YDRPFHKGPK DKENEFKSLW
IERTTLTLTH SLPGISRWFE VERRELVEVS PLENAIQVVE NKNQELRALI SQYQHKQVHG
NINLLSMCLN GVIDAAVNGG IARYQEAFFD KDYITKHPGD AEKIAQLKEL MQEQVHVLGV
GLAVHEKFVH PEMRPLHKKL IDHLTSVISS RYGLRPPYHH PTTRLHVIPS VLAELILTPA
ARGYRPWVTG SPGCMPSGPS IRGVSSVRDC SHLVTGSPSL PDKYRHAREM MLLLPTHRDR
PSSAMYPAAI LENGQLPNFQ RALFQQVVGA CKPCSDPNLS VAEKGTIPLP RWPPLLSVPI
LSVSLLSLST SWPRLSHTLT PRPLCPSRVL TSSVFII
//
