ID A0A3Q1M5E4_BOVIN Unreviewed; 4278 AA.
AC A0A3Q1M5E4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Dynein axonemal heavy chain 17 {ECO:0000313|Ensembl:ENSBTAP00000063494.1};
GN Name=DNAH17 {ECO:0000313|Ensembl:ENSBTAP00000063494.1,
GN ECO:0000313|VGNC:VGNC:28124};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000063494.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000063494.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000063494.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000063494.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000063494.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR Ensembl; ENSBTAT00000072331.1; ENSBTAP00000063494.1; ENSBTAG00000000920.6.
DR VEuPathDB; HostDB:ENSBTAG00000000920; -.
DR VGNC; VGNC:28124; DNAH17.
DR GeneTree; ENSGT00940000154076; -.
DR Proteomes; UP000009136; Chromosome 19.
DR Bgee; ENSBTAG00000000920; Expressed in spermatocyte and 55 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1M5E4; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703:SF4; DYNEIN AXONEMAL HEAVY CHAIN 17; 1.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 3.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 181..236
FT /note="Dynein heavy chain tail"
FT /evidence="ECO:0000259|Pfam:PF08385"
FT DOMAIN 250..356
FT /note="Dynein heavy chain tail"
FT /evidence="ECO:0000259|Pfam:PF08385"
FT DOMAIN 367..656
FT /note="Dynein heavy chain tail"
FT /evidence="ECO:0000259|Pfam:PF08385"
FT DOMAIN 1083..1487
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1624..1950
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 2109..2226
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 2448..2532
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 2583..2842
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 2855..3199
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 3226..3443
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 3687..3807
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 3839..3975
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 3983..4276
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT REGION 754..773
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2847..2898
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3070..3119
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3433..3463
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4278 AA; 488646 MW; E4D45C4645A6E0E1 CRC64;
MTIPPDVRLE YMESVASLVL RFKPDKWSKM MGTEENMALF TDFFEKPDVL VLVLTLNPAG
MIIPCLGFPA SLKSKGMYFI KKRPENIGKD NYKERLVRRL EQSHRILSFQ VLYSLLNQSE
NMSGWPRVVS EDIVKQVHKL KNEMFVMSGK IKGKTLLPIP EHLGSLDGTL EIPSSLDNSL
LHAIETIIID WSHQIRDVLS KDSAQALLDG LHPLPRVEFE FWDARLMNLK YIHEQVMALL
PLVPQFLFHA GLKEANDIVL YLKPLRILLE EMEQLPTFIT KVLYTICFIW ATSEHYNTPS
RIIVILQEFC NQLIDMVTRT FLSPEEVLKG LQGETEEVLS GISLSVNVLK ELYRAYDFCW
YGGFLHQDLY KTAIEFLKLE KIELGGVRGN ILGSQVAQIY DEVFELVKVF ADCKYDPLDP
GDSSFDDDYA DFETKIQDLD RRLATIFCQG FDDCNSIESS AKLLHMCGGL LERPLILAEM
VPRYSVMLEL FDTELDNTKI LYDAQIAASA DGNIPPIHKN MPPVAGQLKW SLELQERLEA
PMRDLNVEAK LVYQKYDEMM ELLRSYRERI YQQWVSGVDK DCHFNLGQPL IQRDPVTNLI
RVNFSKLVAV LREVKYLNFQ HQKDIPTSAE NLFSQYETFR KFVGNLELIV GWYNEVSWCH
IGFLFAAFWE GGVSFRTKVY EPHVEKQVDP VKQQAAMWFC LQENAELFRA DTTSQSWKDY
VNYIDSMVLD EFDQFIRKSL NYLMDNMRHL SQHLNRSPGQ GAHGAKPSPV CSPPARLQTD
LEDMTDLIEM REEISNLVIS AMKEAEEYQD SFERYSYLWT DDPQEFMRNF LTYGRAISRE
DLDSRPEETL PKTPPTLAQF QQQIDSYEKL YEEVSKCDNT KVFNGWLQCD CRPFKQALLN
TIKRWSLMFK RHLGNHVINS LADLEAFMKV ARMGLTKPVK EGDYDGLVEV MGHLMKVKER
QTATDNMFEP LKQTIELLKS YGEEMPEETH VKLQELPEQW TNTKKLALQV KQNVSPLQAN
EVSILRRKCQ QFELKQHEFR ERFRQEAPFS FSDPDPYKSL SKVFLLKEEM GLFEVSVPDY
KQLKACHKEV RLLKELWDMI IMVNTSIDDW KTTKWKNINV EQMDIDCKKF AKDVRSLDKE
MKSWDAFVGL DNTVKNMITS LRAVSELQNP AIRDRHWQQL MQATQVKFEM SDETTLADLL
QLNLHKYEDE VRNIVDKAVK ESGMEKVSFV ENTWSTMEFE HEPHPRTGTM MLKSDEVLVE
TLEDNQVQLQ NLMMSKYLSH FLKEVTSWQQ KLSTADSVIS IWFEVQRTWS HLESIFIGSE
DIRAQLPEDS RRFDDIDIEF KALMEDAVKT PNVVEATNKP GLYDKLEDLK KRLAVCEKAL
AEYLETKRLA FPRFYFVSSA DLLDILSNGN DPVEVSRHLS KLFDSLCKLK FRLDASGKPL
KFGLGMYSKE DEYVDFDQEC NLSGQVEVWL NRVLDRMCAT LRHEIPEAVV TYEEKPREQW
IFDYPAQIAL TCTQIWWATE VGLAFARLEE GYENAIKDYN KKQISQLNAL ITLLIGNLSA
GDRMKIMTIC TIDVHARDVV AKMITAKAWV ESSQAFTWQS QLRHRWDEEK KHCFANICDA
QIQYSYEYLG NTPRLVITPL TDRCYITLTQ SLHLIMGGAP AGPAGTGKTE TTKDLGRALG
TMVYVFNCSE QMDYKSCGNI YKGLAQTGAW GCFDEFNRIS VEVLSVIAVQ VKCVQDAIRA
KKKTFNFLGE MISLIPTVGI FITMNPGYAG RTELPENLKA LFRPCAMVVP DFELICEIML
VAEGFLEARL LARKFITLYT LCKELLSKQD HYDWGLRAIK SVLVVAGSLK RGDPSRAEDQ
VLMRALRDFN IPKIVTDDLP VFMGLIGDLF PALDVPRKRD LNFEKVIKQS IVELQLQAED
GFVLKVVQLE ELLQVRHSVF VIGNAGSGKS QVLRSLNKTY QNLKRKPVAV DLDPKAVTCD
ELFGIINPAT REWKDGLFST IMRDLANITH DGPKWIVLDG DIDPMWIESL NTVMDDNKVL
TLASNERIPL NRTMRLVFEI SHLRTATPAT VSRAGILYIN PADLGWNPVV SSWIERRKVQ
SEKANLMILF DKYLPTCLDK LRFGFKKITP VPEITIIQTI LYLLECLLTE KNAPPDSAKE
LYELYFVFAC FWAFGGAMFQ DQVSNYRVEF SRWWINEFKT IKFPSQGTVF DYYIDPDTKK
FLPWTDKVPA FELDPDVPLQ ASLVHTTETI RIRYFMDLLM EKSWPVMLVG NAGTGKSVLM
GDKLDSLSTD DYLVQAVPFN FYTTSAMLQG ILEKPLEKKS GRNYGPPGTK KLIYFIDDMN
MPEVDKYGTV APHTLIRQHM DHGHWYDRQK LTLKDVHNCQ YVACMNPTSG SFTIDPRLQR
HFCVFAVSFP GQEALTSIYS TILSQHLSYR SAPFASAQES MCLFPGTALH QKVTSTFLPT
AIKFHYVFNL RDLSNIFQGL LFSTAEILKF PLDLVRLWLH EAERVYGDKM VDEKDQDTLR
RVTIASTKKF FDVSQLLFAK PNIFCHFAHG IGDPKYLPVT DLAPLNKLLV EVLDSYNEVN
AVMNLVLFED AVAHICRINR ILESPRGNAL LVGVGGSGKQ SLSRLAAYIS ALDVFQITLK
KGYGIPDLKL DLGAQYIKSA VKNVPSVFLM TDSQVAEEQF LVLINDLLAS GEIPGLFMDD
EVENIISSMR PQVKSLGLTD TREACWKFFI DKVRRNLKVI LCFSPVGSIL RVRARKFPAV
VNCTAINWFH EWPEDALVSV SARFLEDTEG IQPEVKASIS LFMSYVHTTV NEMSKVYLAT
ERRYNYTTPK TFLEQIKLYQ NLLAKKRMEL VAKIERLENG LMKLQSTASQ VDDLKARLAV
QEAELKQKNE NADKLIHVVG VETEKVSKEK AIADEEEIKV EVINKNVTEK QKACETDLAK
AEPALLAAQE ALDTLNKNNL TELKSFGSPP DAVVNVTAAV MILTAPGGKI PKDKSWKAAK
IMMGKVDTFL DSLKKFDKEH IPEACLKAFK PYQGNPTFDP EFIRSKSAAA AGLCSWCINI
VRFYEVYCDV APKRQALEEA NAELAEAQEK LSRIKNKIAV SLNANLSNLT SAFEKATAEK
IKCQQEADAT NRVISLANRL VGGLASENVR WAESVESFKG QGITLCGDVL LISAFVSYVG
YFTKKYRNEL MERFWIPYIN HLKVPIPITK GLDPLTLLTD DADVATWNNQ GLPSDRMSTE
NATILCNTER WPLIVDAQLQ GIKWIKNKYG SELKAIRLGQ KSYLDIIEQA ISEGDTLLIE
NIGETIDPVL DPLLGRNTIK KGKYIKIGDK EVEYHPNFRL ILHTKYFNPH YKPEMQAQCT
LINFLVTRDG LEDQLLAAVV AKERPDLEQL KANLTKSQNE FKIVLKELED SLLARLSAAS
GNFLGDTALV ENLETTKHMA SEIEEKVQEA KITEVKINEA RENYRPAAAR ASLLYFILND
LNKINPIYQF SLKAFNVVFE KAILKTTPAD EVKQRVINLT DEITYSVFMY TARGLFERDK
LIFLAQVAFQ VLSMKKELNP VELDFLLRFP FKAGVVSPVD FLQHQGWGGI KALSEMDEFK
NLDNDIEGSA KRWKKLVESE APEKEIFPKE WKNKTALQKL CMVRCMRPDR MTYACCPLRN
FVEEKMGSKF VEGRSVEFSK SYEESSPSTP IFFILSPGVD PLKDVEALGK KLGFTIDNGK
LHNVSLGQGQ EVVAENALDV AAENGHWVIL QNIHLVARWL STLDKKLERH SAGSHDDYRV
FISAEPAPSP ESHIIPQGIL ENAIKITNEP PTGMYANLHK ALDLFTQDTL EMCTKEIEFK
CILFALCYFH AVVAERRKFG AQGWNRSYPF NNGDLTISIN VLYNYLEANP KVPWDDLRYL
FGEIMYGGHI TDDWDRRLCR TYLAEYIRAE MLEGEILLAP GFQIPPNLDY KGYHEYIDEN
LPPESPYLYG LHPNAEIGFL TVTSEKLFRT VLEMQPKETD SGAGTGVSRE EKVKAVLDEI
LEKIPETFNM AEIMAKAAEK TPYVVVAFQE CERMNILTNE MRRSLKELNL GLKGELTITT
DMEDLSTALF YDTVPDSWVA RAYPSMMGLA AWYADLLLRI RELEAWTTDF ALPTTVWLAG
FFNPQSFLTA IMQSMARKNE WPLDKMCLSV EVTKKNREDM TAPPREGSYV YGLFMEGARW
DTQTGVIAEA RLKELTPAMP VIFIKAIPVD RMETKNIYEC PVYKTRIRGP TYVWTFNLKT
KEKAAKWILA AVALLLQV
//
