ID A0A3Q1M5I8_BOVIN Unreviewed; 1319 AA.
AC A0A3Q1M5I8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=PH domain and leucine rich repeat protein phosphatase 2 {ECO:0000313|Ensembl:ENSBTAP00000065178.1};
GN Name=PHLPP2 {ECO:0000313|Ensembl:ENSBTAP00000065178.1,
GN ECO:0000313|VGNC:VGNC:32841};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000065178.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000065178.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000065178.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000065178.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000065178.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; NP_001193122.1; NM_001206193.1.
DR PaxDb; 9913-ENSBTAP00000053245; -.
DR Ensembl; ENSBTAT00000084668.1; ENSBTAP00000065178.1; ENSBTAG00000007545.7.
DR GeneID; 533130; -.
DR KEGG; bta:533130; -.
DR CTD; 23035; -.
DR VEuPathDB; HostDB:ENSBTAG00000007545; -.
DR VGNC; VGNC:32841; PHLPP2.
DR GeneTree; ENSGT00940000159841; -.
DR OMA; CPEEHPR; -.
DR Proteomes; UP000009136; Chromosome 18.
DR Bgee; ENSBTAG00000007545; Expressed in granulosa cell and 94 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1M5I8; baseline and differential.
DR CDD; cd13322; PH_PHLPP-like; 1.
DR CDD; cd00143; PP2Cc; 1.
DR CDD; cd17241; RA_PHLPP2; 1.
DR Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036457; PPM-type-like_dom_sf.
DR InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF43; LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47-LIKE PROTEIN; 1.
DR Pfam; PF13516; LRR_6; 2.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF00481; PP2C; 1.
DR SMART; SM00364; LRR_BAC; 12.
DR SMART; SM00369; LRR_TYP; 12.
DR SMART; SM00332; PP2Cc; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF81606; PP2C-like; 1.
DR PROSITE; PS51450; LRR; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS51746; PPM_2; 1.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 146..244
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 781..1029
FT /note="PPM-type phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51746"
FT REGION 1056..1150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1174..1195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1285..1319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1058..1098
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1121..1144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1285..1306
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1319 AA; 146406 MW; B37DDEAA10C7F6D3 CRC64;
MKRNGSRNCL NRRSRFGSRE RDWLREDVKR GCVYLYGADT TTATTTTTSS ASSSSSDLHL
VLCTVETPAS EICAGEGRES LYLQLHGDLV RRLEPTERPL QIVYDYLSRL GFDDPARIQE
EAANPDLGCM LRFYGEKPCQ MDHLDRILLS GIYNVRKGKT QLHKWAERLV VLCGTCLIVS
SVKDCQTGKM HILPLVGGKV EEVKRRQYSL AFSSAGAQAQ TYLVSFETLA EYQRWQRQAS
KVVSQRISTV DLSCHSLEEV PEHLFYSQDI TYLNLRHNFM QLERPGGLDT FYKFSQLKGL
NLSHNKLGSF PVLLCEIPTL TELNLSCNGF HDLPSQIGSL LNLQTLCLDG NFLTALPEEL
GNLQQLSSLG ISFNNFSQIP EVYEKLTMLD KVFMAGNRVE VLNLGVLKRM SHVKHVDLRM
NHLKTMIIEN LEGNKYITHM DLRDNRLTDL DLSSLCNLEQ LHCERNQLRE LTLSGFSLRT
LYANSNRLTT VNVYPVPSLL TSLELSRNLL ECVPDWACEA KKIEILDVSY NLLTEVPMRI
LSSLSLRKLM VGHNHVQSLP TLVEHIPLEV LDVQHNLLTR LPDTLFSKAL NLRYLNASAN
SLESLPSACA GEESLSALQL LYLTNNLLTD QCVPVLVGHP HLRILHLANN QLQTFPASKL
NKLEQLEELN LSGNKLKTIP TTIANCKRLH TLVAHSNHIS IFPEILQLPQ IQFVDLSCND
LTEILIPEAL PATLQDLDLT GNTNLVLEHK TLDTFSHITT LKIDQKPLPT TDSTVTSTFW
SHGLAEMAGQ RNKLCVSALA VDNFAEGVGA VYGMFDGDRN EELPRLLQCT MADVLLEEVQ
QSTNDTVFMA NTFLVSHRKL GMAGQKLGCS ALLCYIRPDT ADPMNSFSLT VANVGTCQAV
LCRGGKPVPL SKVFSLEQDP EEAQRVKDQK AIITEDNKVN GVTCCTRLLG CTYLYPWILP
KPHISSTPLT IQDELLILGN KALWEHLSYT EAVNAVRHVQ DPLAAAKKLC TLSQSYGCQD
NVGAMVVYLN IGEEGCTCEM NGLTLPGPMG FASTTIIKDP PKPTTPSSSS GIASEFSSEM
STSEVSSEVG STASDEHNTV GLDAGLLPRP ERRCSLHPAP TSGVFQRQPS CATFSSNQSD
NGLDSDDDQP VEGVITNGSK VEVEVDIHCC RGRDLENSPT LPENSPAPCP EDRSRGSLFG
IRRQNSVNSG ILLPVSKDRT ELQKSPSTSC LYGKKLSNGS IVPLEDSLNL IEVATEAPKK
KTGYFAAPTQ LEPEDQFVIP RDLEEEVKEQ MKHHQESRHE PEPSEEDRTE LPEEFDTAL
//
