ID A0A3Q1M5M7_BOVIN Unreviewed; 2659 AA.
AC A0A3Q1M5M7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Teneurin transmembrane protein 1 {ECO:0000313|Ensembl:ENSBTAP00000065229.1};
GN Name=TENM1 {ECO:0000313|Ensembl:ENSBTAP00000065229.1,
GN ECO:0000313|VGNC:VGNC:35741};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000065229.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000065229.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000065229.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000065229.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000065229.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the tenascin family. Teneurin subfamily.
CC {ECO:0000256|ARBA:ARBA00009385}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR Ensembl; ENSBTAT00000084087.1; ENSBTAP00000065229.1; ENSBTAG00000018819.6.
DR VEuPathDB; HostDB:ENSBTAG00000018819; -.
DR VGNC; VGNC:35741; TENM1.
DR GeneTree; ENSGT01030000234566; -.
DR OMA; DNMGRMI; -.
DR Proteomes; UP000009136; Chromosome X.
DR Bgee; ENSBTAG00000018819; Expressed in oocyte and 47 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1M5M7; baseline.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 5.
DR Gene3D; 2.180.10.10; RHS repeat-associated core; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR008969; CarboxyPept-like_regulatory.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR031325; RHS_repeat.
DR InterPro; IPR009471; Ten_N.
DR InterPro; IPR028916; Tox-GHH_dom.
DR InterPro; IPR006530; YD.
DR NCBIfam; TIGR01643; YD_repeat_2x; 3.
DR PANTHER; PTHR11219; TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE; 1.
DR PANTHER; PTHR11219:SF7; TENEURIN-1; 1.
DR Pfam; PF05593; RHS_repeat; 1.
DR Pfam; PF06484; Ten_N; 2.
DR Pfam; PF15636; Tox-GHH; 1.
DR SMART; SM00181; EGF; 8.
DR SUPFAM; SSF63829; Calcium-dependent phosphotriesterase; 1.
DR SUPFAM; SSF49464; Carboxypeptidase regulatory domain-like; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF101898; NHL repeat; 1.
DR PROSITE; PS00022; EGF_1; 5.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS51361; TENEURIN_N; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 245..270
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..245
FT /note="Teneurin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51361"
FT DOMAIN 519..551
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 649..680
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 688..723
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 101..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 116..133
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 541..550
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 653..663
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 670..679
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 692..702
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 713..722
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2659 AA; 297009 MW; 07BA5E9DC2D9E64E CRC64;
MEFCETPHTL CSGYQTDMHS VSRHGYQLEM GSDVDTETEG AASPDHALRM WIRGMKSEHS
SCLSSRANSA LSLTDTDHER KSDGENGFKF SPVCCDMEAQ AGSTQDMQSS PHNQFTFRPL
PPPPPPPHAC TCARKPPPAA DSLQRRSMTT RSQPSPAAPA PPTSTQDSVH LHNSWVLNSN
IPLETRHFLF KHGSGSSAIF SAASQNYPLT SNTVYSPPPR PLPRSTFSRP AFTFSKPYRC
CNWKCTALSA TAVTVTLALL LAYVIAVHLF GLTWQLQPAE GQLYENGVSK GNRGTESMDT
TYSPIGGKVS DKSEKKVFQK GRAIDTGEVD IGAQVMQTIP PGLFWRFQIT IHHPIYLKFN
ISLAKDSLLG IYGRRNIPPT HTQFDFVKLM DGKQLVKQDS RSSDDTQHSP RNLILTSLQE
TGFIEYMDQG PWYLAFYNDG KKMEQVFVLT TAIEIMDDCS TNCNGNGECI SGHCHCFPGF
LGPDCARDSC PVLCGGNGEY EKGHCVCRNG WKGPECDVPE EQCIDPTCFG HGTCIMGVCI
CVPGYKGEIC EEEDCLDPMC SGHGICVKGE CHCSTGWGGV NCETPLPICQ EQCSGHGTFL
LETGTCSCDP KWTGADCSTE LCTMECGSHG VCARGICQCE EGWVGPTCEE RSCHSHCAEH
GQCKDGKCEC SPGWEGDHCT IAHYLDAVRD GCPGLCFGNG RCTLDQNGWH CVCQVGWSGT
GCNVVMEMLC GDNLDNDGDG LTDCVDPDCC QQSNCYVSPL CQGSPDPLDL IQQSQSLLSQ
HTLRLFYDRI KFLIGKDSTH VIPPEISFDS RRACVIRGQV VAVDGTPLVG VNVSFLHHSD
YGFTISRQDG SFDLVAIGGI SVVLIFDRSP FLPEKRTLWL PWNQFIVVEK VTMQRVMSDP
PSCDISNFIS PNPIVLPSPL TSFGGSCPER GTIVPELQVV QEEILIPSSF VRLSYLSSRT
PGYKTLLRIL LTHSTIPVGM IKVHLTVAVE GRLTQKWFPA AVNLVYTFAW NKTDIYGQKV
WGLAEALVSV GYEYEMCPDF ILWEKRTVIL QGFEMDASNL GGWSLNKHHI LNPQSGIIHK
GNGENMFISQ QPPVIATIMG NGHQRSVACT NCNGPAHNNK LFAPVALASG PDGSVYVGDF
NFVRRIFPSG NSVSILELRN RDTRHSTSPA HKYYLAMDPM SESLYLSDTN TRKVYKLKSL
VETKDLSKNF EVVAGTGDQC LPFDQSHCGD GGRASEASLN SPRGITVDRH GFIYFVDGTM
IRRIDENAVI TTVIGSNGLT STQPLSCDSG MDITQVRLEW PTDLAVNPMD NSLYVLDNNI
VLQISENRRV RIIAGRPIHC QVPGIDHFLV SKVAIHSTLE SARAISVSHS GLLFIAETDE
RKVNRIQQVT TNGEISIIAG APTDCDCKID PNCDCFSGDG GYAKDAKMKA PSSLAVSPDG
TLYVADLGNV RIRTISRNQA HLNDMNLYEI ASPADQELYQ FTVNGTHLHT LNLITRDYVY
NFTYNAEGDL GAITSSNGNS VHIRRDASGM PLWLVVPGGQ VYWLTISSNG VLKRVSAQGY
NLALMTYPGN TGLLATKSNE NGWTTVYEYD PEGHLTNATF PTGDVSSFHS DLEKLTKVEL
DTSNRENVLM STNLTATSTI YILKQENTQS TYRVSPDGSL RVTFASGMEI SLSSEPHILA
GAVNPTLGKC NISLPGEHNA NLIEWRQRKE QNKGNISAFE RRLRAHNRNL LSIDFDHMTR
TGKIYDDHRK FTLRILYDQT GRPVLWSPVS RYNEVNITYS PSGLVTFIQR GTWNEKMEYD
QSGKIISRTW ADGKIWSYTY LEKSVMLLLH SQRRYIFEYD QSDCLLSVTM PSMVRHSLQT
MLSVGYYRNI YTPPDSSTSF IQDYSRDGRL LQTLHLGTGR RVLYKYTKQA RLSEILYDTT
QVTLTYEESS GVIKTIHLMH DGFICTIRYR QTGPLIGRQI FRFSEEGLVN ARFDYSYNNF
RVTSMQAVIN ETPLPIDLYR YVDVSGRTEQ FGKFSVINYD LNQVITTTVM KHTKIFSANG
QVIEVQYEIL KAIAYWMTIQ YDNMGRMVIC DIRVGVDANI TRYFYEYDAD GQLQTVSVND
KTQWRYSYDL NGNINLLSHG NSARLTPLRY DLRDRITRLG EIQYKMDEDG FLRQRGNDVF
EYNSNGLLQK AYNKASGWTV QYYYDGLGRR VASKSSPGQH LQFFYADLAN PIRVTHLYNH
TSSEITSLYY DLQGHLIAME LSSGEEYYVA CDNTGTPLAV FSSRGQVIKE ILYTPYGDIY
HDTYPDFQVI IGFHGGLYDF LTKLVHLGQR DYDVIAGRWT TPNHHIWKQL NLLPKPFNLY
SFENNYPVGK IQDVAKYTTD IGSWLELFGF QLHNVLPGFP KPELENLELT YELLQLQTKT
QEWDPGKTIL GIQCELQKQL RNFISLDQLP MTPRYGDGRC LEGGKQPRFA AVPSVFGKGI
KFAIKDGIVT ADIIGVANED SRRLAAILNN AHYLENLHFT IEGRDTHYFI KLGSLEEDLV
LIGNTGGRRI LENGVNVTVS QMTSVLNGRT RRFADIQLQH GALCFNIRYG TTVEEEKNHV
LEIARQRAVA QAWTKEQRRL QEGEEGIRAW TEGEKQQLLS TGRVQGYDGY FVLSVEQYLE
LSDSANNIHF MRQSEIGRR
//
