ID A0A3Q1M6G2_BOVIN Unreviewed; 963 AA.
AC A0A3Q1M6G2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Protein phosphatase 1 regulatory subunit {ECO:0000256|PIRNR:PIRNR038141};
GN Name=PPP1R12B {ECO:0000313|Ensembl:ENSBTAP00000065965.1,
GN ECO:0000313|VGNC:VGNC:106875};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000065965.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000065965.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000065965.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000065965.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000065965.1};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBUNIT: PP1 comprises a catalytic subunit, and one or several
CC targeting or regulatory subunits. {ECO:0000256|PIRNR:PIRNR038141}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, stress fiber
CC {ECO:0000256|ARBA:ARBA00004529}.
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DR AlphaFoldDB; A0A3Q1M6G2; -.
DR Ensembl; ENSBTAT00000070021.1; ENSBTAP00000065965.1; ENSBTAG00000011772.6.
DR VEuPathDB; HostDB:ENSBTAG00000011772; -.
DR VGNC; VGNC:106875; PPP1R12B.
DR GeneTree; ENSGT00940000157067; -.
DR Proteomes; UP000009136; Chromosome 16.
DR Bgee; ENSBTAG00000011772; Expressed in corpus luteum and 105 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1M6G2; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR GO; GO:0001725; C:stress fiber; IEA:UniProtKB-SubCell.
DR GO; GO:0019208; F:phosphatase regulator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019901; F:protein kinase binding; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd21944; IPD_MYPT1; 1.
DR Gene3D; 6.10.140.390; -; 1.
DR Gene3D; 6.10.250.1820; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR017401; MYPT1/MYPT2/Mbs85.
DR InterPro; IPR031775; PRKG1_interact.
DR PANTHER; PTHR24179; PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12; 1.
DR PANTHER; PTHR24179:SF18; PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12B; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF15898; PRKG1_interact; 1.
DR PIRSF; PIRSF038141; PP1_12ABC_vert; 1.
DR SMART; SM00248; ANK; 5.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 4.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR038141};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT REPEAT 88..120
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 121..153
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 214..246
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 247..279
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 872..963
FT /note="cGMP-dependent protein kinase interacting"
FT /evidence="ECO:0000259|Pfam:PF15898"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 332..546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 552..571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 576..769
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 834..869
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 877..957
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..32
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 332..359
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 397..412
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 472..486
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 532..546
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 601..627
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 632..648
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 729..759
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 844..869
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 963 AA; 105503 MW; 1D773898197D760B CRC64;
MAELEHLGGK RAESARARRA EQLRRWRGSP TEQEPADRPG AGPQARRGGP RVRFEDGAVF
LAACSSGDTD EVRRLLARGA DVDTANVDGL TALHQACIDE NLDVVKFLVE NGASVNQQDN
EGWTPLHAAA SCGYLNIAEY FINHGASVGI VNSEGEVPSD LAEEPAMKDL LLEQVKKQGL
DLEQARRQEE QQMLQDARQW LNSGRIADVR QARSGATALH VAAAKGYSEV LRLLIQAGYE
LNVQDHDGWT PLHAAAHWGV KEACSILAEA LCDMDIRNKL GQTPFDVADE GLVEHLETLQ
KRQSVLRSEK ETRNKLIESD LNSKLHSRLF KNKEKMLCEE ETPKSQRVEE SKESSSSSSD
EGEDEASESE AEKEAGDPEA GRPQSAGGRH VSEGRWSQPW GTDSQTGPRP FPSSLFSKPE
ETRDESPCSW RLGLRKTGSQ NVLSEAAGAR EALRDRGASV HRSASSPRIS ALMDNREKER
ETRSSLSSLG LRRPGSTSDL EEKENRESAA NLVRSGSQPR QPWRDAAKGS ETPQTAAPST
YVSTFLKRTP YRSQADSTAE RADGVACSSP LCVITNRPPP STASGVPATT LLCAPGPEPS
VEARQRRRSY LTPVRDEEAE SLRKARSRQA RQTRRSTQGV TLTDLQEAER TFSRSRVERQ
AQEQPSLKPV GPGALEGGPR KHEPLAAPTQ EAGESRQPWG RSPEGEPVYH PLRCPAQPEQ
PTAPASPSAP RPSLYSSSYL LRTGGSSAPD SQSSEPPTDT AGPRDMDKNG TLGFGKCSLQ
SHCVLGAGWP LPRRACPVAL STSGENVRCP LASPPTPCCS RNQLPLPCVS HRLESGGSDA
STERASARAR REAREARLAT LSSRTEEDGG RDYRKLYESA LTENQKLKTK LQEAQLELAD
VKSKLEKMAQ VRRGEENQER RALERKMSEM EEEMKVLTEL KSDNQRLKDE NGALIRVISK
LSK
//