ID   A0A3Q1M7K2_BOVIN        Unreviewed;      1632 AA.
AC   A0A3Q1M7K2;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Pappalysin 1 {ECO:0000313|Ensembl:ENSBTAP00000066366.1};
GN   Name=PAPPA {ECO:0000313|Ensembl:ENSBTAP00000066366.1,
GN   ECO:0000313|VGNC:VGNC:32572};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000066366.1, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000066366.1, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000066366.1,
RC   ECO:0000313|Proteomes:UP000009136};
RA   Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA   Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA   Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT   "ARS-UCD1.2.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000066366.1}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000066366.1};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase M43B family.
CC       {ECO:0000256|ARBA:ARBA00008721}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR   STRING; 9913.ENSBTAP00000066366; -.
DR   PaxDb; 9913-ENSBTAP00000053616; -.
DR   Ensembl; ENSBTAT00000086645.1; ENSBTAP00000066366.1; ENSBTAG00000004010.7.
DR   VEuPathDB; HostDB:ENSBTAG00000004010; -.
DR   VGNC; VGNC:32572; PAPPA.
DR   GeneTree; ENSGT00940000156654; -.
DR   InParanoid; A0A3Q1M7K2; -.
DR   OMA; KQVVCEP; -.
DR   Reactome; R-BTA-381426; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
DR   Proteomes; UP000009136; Chromosome 8.
DR   Bgee; ENSBTAG00000004010; Expressed in granulosa cell and 41 other cell types or tissues.
DR   ExpressionAtlas; A0A3Q1M7K2; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IBA:GO_Central.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR   CDD; cd00033; CCP; 3.
DR   CDD; cd04275; ZnMc_pappalysin_like; 1.
DR   Gene3D; 2.60.120.200; -; 1.
DR   Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR   Gene3D; 2.10.70.10; Complement Module, domain 1; 4.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR006558; LamG-like.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR011936; Myxo_disulph_rpt.
DR   InterPro; IPR000800; Notch_dom.
DR   InterPro; IPR043543; PAPPA/PAPPA2.
DR   InterPro; IPR008754; Peptidase_M43.
DR   InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR   InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR   NCBIfam; TIGR02232; myxo_disulf_rpt; 1.
DR   PANTHER; PTHR46130; LAMGL DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR46130:SF2; PAPPALYSIN-1; 1.
DR   Pfam; PF13385; Laminin_G_3; 1.
DR   Pfam; PF05572; Peptidase_M43; 1.
DR   Pfam; PF00084; Sushi; 2.
DR   SMART; SM00032; CCP; 4.
DR   SMART; SM00560; LamGL; 1.
DR   SMART; SM00004; NL; 3.
DR   SUPFAM; SSF57535; Complement control module/SCR domain; 4.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF49265; Fibronectin type III; 1.
DR   SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 2.
DR   PROSITE; PS50923; SUSHI; 2.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00302}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Sushi {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..1632
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018752628"
FT   DOMAIN          1291..1352
FT                   /note="Sushi"
FT                   /evidence="ECO:0000259|PROSITE:PS50923"
FT   DOMAIN          1421..1481
FT                   /note="Sushi"
FT                   /evidence="ECO:0000259|PROSITE:PS50923"
FT   REGION          23..101
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          737..756
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        56..71
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        1423..1466
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ   SEQUENCE   1632 AA;  180887 MW;  CAFF1789E69E67F5 CRC64;
     MRLWSWVLRL GLLSAALGCG LAERPRRARR DPRAGRPPRP AAGPATCATR AARGRRASPP
     PPPPPPPGGA WEAVRVPRRR QQREARGAAE EPSPPSRALY FSGRGEQLRL RADLELPRDA
     FTLQVWLRAE GGQSSPAVIT GLYDKCSYAS RDRGWVVGIH TVSDQGNRDP RYFFSLKTDR
     ARQVTTINAH RSYLPGQWVY LAATYDGRLM KLYMNGAQVA TSGEQVGGIF SPLTQKCKVL
     MLGGSTLNHN YRGSVERFSL WKVARTQREI LLDMGTRGPQ GPLPQLLLQE NWDNVKRAWS
     PMKDGSSPRV EVSGAHGFRL DTSLEPPLCG QTLCDSPEVI ANYNQLPRLR QPKVVRYRVV
     NLHDDGRENP TVSRQQIDFQ HQQLAEAFKH YNISWELEVL EVSNSSLRRR LILANCDISK
     IGDENCDPEC NHTLTGHDGG DCRHLRHPAF AKKQQNGVCD MDCNYERFNF DGGECCDPNI
     TDVTKTCFEP DNLHRAYLDV NEMKNILRLD GSTHLNIFFA NSSEEELAGV ATWPWDKEAL
     MHLGGIVLNP SFYGIPGHTH TMIHEIGHSL GLYHIFRGIS EIQSCSDPCM ETEPSYETGD
     LCSDTNPAPK HKFCGDPGPG NDTCGFNSFF NTPYNNFMSY ADDDCTDSFT PNQVARMHCY
     LDLVYQGWQP SRKPVPIALA PQVVSHTPDS VMLEWFPPID GHFFERELGS ACDLCLEGRF
     LVQYAFNASS PMPCGPSGHW SPREAEGHPD VEQPCKSSVR TWSPNSAVNP HTVPPACPEP
     QGCHLDLRFR YPLVPESLTV WVTFVSTDWD SSGAVNDIKL LGVSGNNISL GPQNVFCDVP
     LTIKLQDVGE EVYGVQIYTL DEHLEIDAAM LTSVADSPLC LECKPLQYKV VRDPPLQVDV
     ASTLHFSRRF TDTDVHLGSR YQYWVIAISG NEESEPSPAA TYIHGSGYCG DGIIQRSQGE
     ECDDMNKING DGCSLFCRQE VSFNCIDEPS RCYFHDGDGV CEEFEQKTSI KDCGVYTPQG
     FLDQWASNAT VSHQDQQCPG WVIIGQPAAS QVCRTKVIDL SEGISQHAWY PCTISYPYSQ
     LAQTTFWPPT SSAFQAYFSQ PMVATAVIVH LVTDGTYYGD QKQETISVQL LDTNEQSHDL
     GFHVLSCRNN PLIIPVVHDL SQPFYHSQAV RVSFSSPLVA ISGVALRSFD NFDPVTLSSC
     QRGETYSSAE QSCVHFACEA ADCPKLAVEN ASLNCSSSDG YHGAQCAVRC RTGYVLQIQR
     DDELIKSQTG PSVTVTCKEG KWNKQVACEP VDCGVPDQHH VYAASFSCLE GTTFGSKCSF
     QCRHPAQLKG NNSLLTCMED GLWSFPEALC ELMCLAPPPV PNADLQTARC RENKHKVGSF
     CKYKCRPGYH VPGSSRKSKK RAFKTQCTQD GSWQEGACVP VTCDPPPPKF HGLYQCTNGF
     QFNSECRINC EDSDATQGRG NNVIHCRKDG TWSGSFHICQ EMQGECSAPD QLNSNLKLQC
     PEGYAIDSPC KCQGEVKTQK IQEGNMGVEC DSGEVMAPSQ PVVCTAGLKW YPHPALIYCV
     KGCEPFMGDN YCDAINNRAF CNYDGGDCCA STVKTKKVTP FPMSCDLQGD CACRDPQAQE
     HSRKDLRGYS HG
//