ID A0A3Q1M7K2_BOVIN Unreviewed; 1632 AA.
AC A0A3Q1M7K2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Pappalysin 1 {ECO:0000313|Ensembl:ENSBTAP00000066366.1};
GN Name=PAPPA {ECO:0000313|Ensembl:ENSBTAP00000066366.1,
GN ECO:0000313|VGNC:VGNC:32572};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000066366.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000066366.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000066366.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000066366.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000066366.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase M43B family.
CC {ECO:0000256|ARBA:ARBA00008721}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR STRING; 9913.ENSBTAP00000066366; -.
DR PaxDb; 9913-ENSBTAP00000053616; -.
DR Ensembl; ENSBTAT00000086645.1; ENSBTAP00000066366.1; ENSBTAG00000004010.7.
DR VEuPathDB; HostDB:ENSBTAG00000004010; -.
DR VGNC; VGNC:32572; PAPPA.
DR GeneTree; ENSGT00940000156654; -.
DR InParanoid; A0A3Q1M7K2; -.
DR OMA; KQVVCEP; -.
DR Reactome; R-BTA-381426; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
DR Proteomes; UP000009136; Chromosome 8.
DR Bgee; ENSBTAG00000004010; Expressed in granulosa cell and 41 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1M7K2; baseline and differential.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004222; F:metalloendopeptidase activity; IBA:GO_Central.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR CDD; cd00033; CCP; 3.
DR CDD; cd04275; ZnMc_pappalysin_like; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 4.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR006558; LamG-like.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR011936; Myxo_disulph_rpt.
DR InterPro; IPR000800; Notch_dom.
DR InterPro; IPR043543; PAPPA/PAPPA2.
DR InterPro; IPR008754; Peptidase_M43.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR NCBIfam; TIGR02232; myxo_disulf_rpt; 1.
DR PANTHER; PTHR46130; LAMGL DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46130:SF2; PAPPALYSIN-1; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF05572; Peptidase_M43; 1.
DR Pfam; PF00084; Sushi; 2.
DR SMART; SM00032; CCP; 4.
DR SMART; SM00560; LamGL; 1.
DR SMART; SM00004; NL; 3.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 4.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 2.
DR PROSITE; PS50923; SUSHI; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1632
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018752628"
FT DOMAIN 1291..1352
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1421..1481
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT REGION 23..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 737..756
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..71
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1423..1466
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 1632 AA; 180887 MW; CAFF1789E69E67F5 CRC64;
MRLWSWVLRL GLLSAALGCG LAERPRRARR DPRAGRPPRP AAGPATCATR AARGRRASPP
PPPPPPPGGA WEAVRVPRRR QQREARGAAE EPSPPSRALY FSGRGEQLRL RADLELPRDA
FTLQVWLRAE GGQSSPAVIT GLYDKCSYAS RDRGWVVGIH TVSDQGNRDP RYFFSLKTDR
ARQVTTINAH RSYLPGQWVY LAATYDGRLM KLYMNGAQVA TSGEQVGGIF SPLTQKCKVL
MLGGSTLNHN YRGSVERFSL WKVARTQREI LLDMGTRGPQ GPLPQLLLQE NWDNVKRAWS
PMKDGSSPRV EVSGAHGFRL DTSLEPPLCG QTLCDSPEVI ANYNQLPRLR QPKVVRYRVV
NLHDDGRENP TVSRQQIDFQ HQQLAEAFKH YNISWELEVL EVSNSSLRRR LILANCDISK
IGDENCDPEC NHTLTGHDGG DCRHLRHPAF AKKQQNGVCD MDCNYERFNF DGGECCDPNI
TDVTKTCFEP DNLHRAYLDV NEMKNILRLD GSTHLNIFFA NSSEEELAGV ATWPWDKEAL
MHLGGIVLNP SFYGIPGHTH TMIHEIGHSL GLYHIFRGIS EIQSCSDPCM ETEPSYETGD
LCSDTNPAPK HKFCGDPGPG NDTCGFNSFF NTPYNNFMSY ADDDCTDSFT PNQVARMHCY
LDLVYQGWQP SRKPVPIALA PQVVSHTPDS VMLEWFPPID GHFFERELGS ACDLCLEGRF
LVQYAFNASS PMPCGPSGHW SPREAEGHPD VEQPCKSSVR TWSPNSAVNP HTVPPACPEP
QGCHLDLRFR YPLVPESLTV WVTFVSTDWD SSGAVNDIKL LGVSGNNISL GPQNVFCDVP
LTIKLQDVGE EVYGVQIYTL DEHLEIDAAM LTSVADSPLC LECKPLQYKV VRDPPLQVDV
ASTLHFSRRF TDTDVHLGSR YQYWVIAISG NEESEPSPAA TYIHGSGYCG DGIIQRSQGE
ECDDMNKING DGCSLFCRQE VSFNCIDEPS RCYFHDGDGV CEEFEQKTSI KDCGVYTPQG
FLDQWASNAT VSHQDQQCPG WVIIGQPAAS QVCRTKVIDL SEGISQHAWY PCTISYPYSQ
LAQTTFWPPT SSAFQAYFSQ PMVATAVIVH LVTDGTYYGD QKQETISVQL LDTNEQSHDL
GFHVLSCRNN PLIIPVVHDL SQPFYHSQAV RVSFSSPLVA ISGVALRSFD NFDPVTLSSC
QRGETYSSAE QSCVHFACEA ADCPKLAVEN ASLNCSSSDG YHGAQCAVRC RTGYVLQIQR
DDELIKSQTG PSVTVTCKEG KWNKQVACEP VDCGVPDQHH VYAASFSCLE GTTFGSKCSF
QCRHPAQLKG NNSLLTCMED GLWSFPEALC ELMCLAPPPV PNADLQTARC RENKHKVGSF
CKYKCRPGYH VPGSSRKSKK RAFKTQCTQD GSWQEGACVP VTCDPPPPKF HGLYQCTNGF
QFNSECRINC EDSDATQGRG NNVIHCRKDG TWSGSFHICQ EMQGECSAPD QLNSNLKLQC
PEGYAIDSPC KCQGEVKTQK IQEGNMGVEC DSGEVMAPSQ PVVCTAGLKW YPHPALIYCV
KGCEPFMGDN YCDAINNRAF CNYDGGDCCA STVKTKKVTP FPMSCDLQGD CACRDPQAQE
HSRKDLRGYS HG
//