ID A0A3Q1M881_BOVIN Unreviewed; 748 AA.
AC A0A3Q1M881;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=T-box transcription factor 3 {ECO:0000313|Ensembl:ENSBTAP00000064625.1};
GN Name=TBX3 {ECO:0000313|Ensembl:ENSBTAP00000064625.1,
GN ECO:0000313|VGNC:VGNC:53924};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000064625.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000064625.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000064625.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000064625.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000064625.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00201}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00201}.
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DR AlphaFoldDB; A0A3Q1M881; -.
DR SMR; A0A3Q1M881; -.
DR STRING; 9913.ENSBTAP00000064625; -.
DR Ensembl; ENSBTAT00000077533.1; ENSBTAP00000064625.1; ENSBTAG00000021706.6.
DR VEuPathDB; HostDB:ENSBTAG00000021706; -.
DR VGNC; VGNC:53924; TBX3.
DR GeneTree; ENSGT00940000158066; -.
DR InParanoid; A0A3Q1M881; -.
DR OMA; QGIAMSP; -.
DR OrthoDB; 5323209at2759; -.
DR Proteomes; UP000009136; Chromosome 17.
DR Bgee; ENSBTAG00000021706; Expressed in prostate gland and 99 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1M881; baseline and differential.
DR GO; GO:0005929; C:cilium; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IEA:Ensembl.
DR GO; GO:0008595; P:anterior/posterior axis specification, embryo; IEA:Ensembl.
DR GO; GO:0003167; P:atrioventricular bundle cell differentiation; IEA:Ensembl.
DR GO; GO:1905222; P:atrioventricular canal morphogenesis; IEA:Ensembl.
DR GO; GO:0001568; P:blood vessel development; IEA:Ensembl.
DR GO; GO:0060444; P:branching involved in mammary gland duct morphogenesis; IEA:Ensembl.
DR GO; GO:0060317; P:cardiac epithelial to mesenchymal transition; IEA:Ensembl.
DR GO; GO:1905072; P:cardiac jelly development; IEA:Ensembl.
DR GO; GO:0060923; P:cardiac muscle cell fate commitment; IEA:Ensembl.
DR GO; GO:0001708; P:cell fate specification; IBA:GO_Central.
DR GO; GO:0090398; P:cellular senescence; IEA:Ensembl.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0042733; P:embryonic digit morphogenesis; IEA:Ensembl.
DR GO; GO:0035115; P:embryonic forelimb morphogenesis; IEA:Ensembl.
DR GO; GO:0035116; P:embryonic hindlimb morphogenesis; IEA:Ensembl.
DR GO; GO:0003272; P:endocardial cushion formation; IEA:Ensembl.
DR GO; GO:0030540; P:female genitalia development; IEA:Ensembl.
DR GO; GO:0046884; P:follicle-stimulating hormone secretion; IEA:Ensembl.
DR GO; GO:0001947; P:heart looping; IEA:Ensembl.
DR GO; GO:0061017; P:hepatoblast differentiation; IEA:Ensembl.
DR GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
DR GO; GO:0021761; P:limbic system development; IEA:Ensembl.
DR GO; GO:0032275; P:luteinizing hormone secretion; IEA:Ensembl.
DR GO; GO:0030539; P:male genitalia development; IEA:Ensembl.
DR GO; GO:0060596; P:mammary placode formation; IEA:Ensembl.
DR GO; GO:0048332; P:mesoderm morphogenesis; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:2000137; P:negative regulation of cell proliferation involved in heart morphogenesis; IEA:Ensembl.
DR GO; GO:0030857; P:negative regulation of epithelial cell differentiation; IEA:Ensembl.
DR GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
DR GO; GO:2000737; P:negative regulation of stem cell differentiation; IEA:Ensembl.
DR GO; GO:0003151; P:outflow tract morphogenesis; IEA:Ensembl.
DR GO; GO:0045787; P:positive regulation of cell cycle; IEA:Ensembl.
DR GO; GO:2000648; P:positive regulation of stem cell proliferation; IEA:Ensembl.
DR GO; GO:0061635; P:regulation of protein complex stability; IEA:Ensembl.
DR GO; GO:0031647; P:regulation of protein stability; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0060021; P:roof of mouth development; IEA:Ensembl.
DR GO; GO:0048752; P:semicircular canal morphogenesis; IEA:Ensembl.
DR GO; GO:0060931; P:sinoatrial node cell development; IEA:Ensembl.
DR GO; GO:0001501; P:skeletal system development; IEA:Ensembl.
DR GO; GO:0051145; P:smooth muscle cell differentiation; IEA:Ensembl.
DR GO; GO:0010159; P:specification of animal organ position; IEA:Ensembl.
DR GO; GO:0019827; P:stem cell population maintenance; IEA:Ensembl.
DR GO; GO:0072089; P:stem cell proliferation; IEA:Ensembl.
DR GO; GO:0072105; P:ureteric peristalsis; IEA:Ensembl.
DR GO; GO:0060412; P:ventricular septum morphogenesis; IEA:Ensembl.
DR CDD; cd20188; T-box_TBX2_3-like; 1.
DR Gene3D; 2.60.40.820; Transcription factor, T-box; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR046360; T-box_DNA-bd.
DR InterPro; IPR036960; T-box_sf.
DR InterPro; IPR022582; TBX2/3_TAD.
DR InterPro; IPR048387; TBX2_3_RD.
DR InterPro; IPR001699; TF_T-box.
DR InterPro; IPR018186; TF_T-box_CS.
DR PANTHER; PTHR11267; T-BOX PROTEIN-RELATED; 1.
DR PANTHER; PTHR11267:SF91; T-BOX TRANSCRIPTION FACTOR TBX3; 1.
DR Pfam; PF00907; T-box; 1.
DR Pfam; PF12598; TBX; 1.
DR Pfam; PF20627; TBX2-3_RD; 1.
DR PRINTS; PR00937; TBOX.
DR SMART; SM00425; TBOX; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS01283; TBOX_1; 1.
DR PROSITE; PS01264; TBOX_2; 1.
DR PROSITE; PS50252; TBOX_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00201};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00201}; Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 107..305
FT /note="T-box"
FT /evidence="ECO:0000259|PROSITE:PS50252"
FT REGION 323..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 355..478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 693..723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..337
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 355..369
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 371..390
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 439..453
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 693..713
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 748 AA; 79752 MW; 5C031E8757E25558 CRC64;
MSLSMRDPVI PGTSMAYHPF LPHRAPDFAM SAVLGHQPPF FPALTLPPNG AAALSLPGAL
AKPIMDQLVG AAETGIPFSS LGPQTHLRPL KTMEPEEEVE DDPKVHLEAK ELWDQFHKRG
TEMVITKSGR RMFPPFKVRC SGLDKKAKYI LLMDIIAADD CRYKFHNSRW MVAGKADPEM
PKRMYIHPDS PATGEQWMSK VVTFHKLKLT NNISDKHGFT LAFPSDQATW QGNYSFGTQT
ILNSMHKYQP RFHIVRANDI LKLPYSTFRT YLFPETEFIA VTAYQNDKIT QLKIDNNPFA
KGFRDTGNGR REKRKQLTLQ SMRVFDDRHK KENGTSDESS SEQAAFNCFA QSSSPAVSTV
GTSNLKDLCP SEGESDAEAD SKEEHGPEAC DTAKISTTTS EDPCRDKGSP AVKAHLFAAE
PGGRARDSGR LDKASPDSRH SPATISSSTR GLGAEERRSP GRDSAATSKA AEEARVLPGK
EAFAPLTVQT DPAAAHLGQG PLPGLGFAPG LAGQQFFNGH PLFLHPGQFA MGGAFSSMAA
GMGPLLATVS GASTGVSGLD STAMASAAAA QGLSGASATL PFHLQQHVLA SQGLAMSPFG
SLFPYPYTYM AAAAAASSAA ASSSVHRHPF LNLNTMRPRL RYSPYSIPLP VPDSSGLLTT
ALPSMAAAAA TAGPLDGKAA ALAASPASVA VDSGSELNSR SSTLSSSSVS LSPKLCPEKE
AATSELQNIQ RLVSGLEAKP DRSRSASP
//
