ID A0A3Q1M886_BOVIN Unreviewed; 2200 AA.
AC A0A3Q1M886;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Neuron navigator 3 {ECO:0000313|Ensembl:ENSBTAP00000064630.1};
GN Name=NAV3 {ECO:0000313|Ensembl:ENSBTAP00000064630.1,
GN ECO:0000313|VGNC:VGNC:31892};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000064630.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000064630.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000064630.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000064630.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000064630.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the Nav/unc-53 family.
CC {ECO:0000256|ARBA:ARBA00006255}.
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DR RefSeq; XP_010803032.1; XM_010804730.2.
DR Ensembl; ENSBTAT00000069430.1; ENSBTAP00000064630.1; ENSBTAG00000009852.7.
DR VEuPathDB; HostDB:ENSBTAG00000009852; -.
DR VGNC; VGNC:31892; NAV3.
DR GeneTree; ENSGT00940000158014; -.
DR Proteomes; UP000009136; Chromosome 5.
DR Bgee; ENSBTAG00000009852; Expressed in spermatid and 81 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1M886; baseline and differential.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0022008; P:neurogenesis; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR CDD; cd21286; CH_NAV3; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR039041; Nav/unc-53.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12784:SF18; NEURON NAVIGATOR 3; 1.
DR PANTHER; PTHR12784; STEERIN; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF00307; CH; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00033; CH; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50021; CH; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 77..184
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 208..589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 878..1306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1487..1597
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1671..1696
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2175..2200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1401..1484
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1615..1670
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 208..247
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 257..364
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 424..443
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 461..495
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 516..550
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 557..583
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 880..922
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 923..957
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 978..1012
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1028..1042
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1074..1094
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1110..1194
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1208..1233
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1285..1306
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1506..1525
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1542..1560
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1680..1696
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2200 AA; 236377 MW; 21905ADAAEE2B529 CRC64;
MPVLGVASKL RQPAVGSKPV HTALLIPSLG TTGPQRSSSR PLELTELESS MLSCQLTFKS
NCESEEKKPL QGKAKETEDS KIYTDWANHY LAKSGHKRLI KDLQQDIADG VLLAEIIQII
ANEKVEDING CPRSQSQMIE NVDVCLSFLA ARGVNVQGLS AEEIRNGNLK AILGLFFSLS
RYKQQQHHQQ QYYQSLVELQ QRVTHASPQA EASQAKTQQD MQSSLAARYA TQSNHSGIAT
SQKKPTRLPG PSRVPAAGNS SKVQGASNLN RRSQSFNSID KNKPPNYANG NEKDSSKGPQ
PSSGVNGNMQ PPGTAGQPPA SAIPSPSTSK PWRSKSMNAK HSATSTMLTV KQGSPTTSPT
PSADRLKPPA SEGVKTAPSG QKSMLEKFKL VNARTALRPP QSASSGPSDG VKEDDAFSES
GEMEGLNSGL NSGGSTNSSP KVSPKLAPPK AGSKNLSNKK SLLQPKEKEE KNRDKSKVCT
EKLVKDEKDQ MMETAPKKTS KIASLIPKGS KTTAAKKESL IPSSSGIPKP GSKVPTAKQT
VSPGNSASKE SEKFRTTKGS PSQSFPKPIT TEKASTSSCP APLEGRETSH ASLAGSSVGL
VVQGSGQSMG NGAVQLPQQQ QHSHPNTATV APFIYRAHPE NEGTSLPSAD SCTSPTKMDL
SYSKTAKQCL EEISGEDPET RRMRTVKNIA DLRQNLEETM SSLRGTQISH STLETTFDST
VTTEVNGRTI PNLTGRPTPM TWRLGQACPR LQAGDAPSLG AGYPRSGTGR FIHTDPSRFM
YTTPLRRAAV SRLGNMSQID MSEKASSDLD MSAEVDVGGY MSDGDILGKS LRTDDINSGY
MTDGGLNLYT RSLHRAPDTT ASRDVIQRGL HDVAVDADSW DDSSSVSSGL SDTLDNISTD
DLNTTSSVSS YSNITVPSRK NTQLKTDSEK RSATDEPWES TEELKKPEED FDSHGDGGGK
WKGVSSGLPE DPEKTGQKAS LAVSQTGSWR RGMSAQGGAP SRQKTGTSAL KTPGKTDDAK
ASEKGKSPLK GSSLQRSPSD AGKSSGDEGK KPPSGIGRST ATGSFGFKKP SGVGSSAMIT
SSGATITSGS ATLGKIPKSA AIGGKSNAGR KTSLDGSQNQ DDVGLHVSTK TSLQYRSLPR
PSKSSTSGIP GRGGHRSSTS SIDSNVSSKS AGATTSKLRE PTKIGSGRSS PVTVNQTDKE
KEKVAVSDSE SVSLSGSPKS SPTSASACGT QGLRQPGSKY PDIASPTFRS MQLDRNTLPK
KGLRYTPSSR QANQEEGKEW LRSHSTGGLQ DTGNQSPLVS PSAMSSSATG KYHFSNLVSP
TNLSQFNLPG PSMMRSNSIP AQDSSFDLYD DSQLCGSATS LEERPRAISH SGSFRDSMEE
VHGSSLSLVS STSSLYSTAE EKAHSEQIHK LRRELVASQE KVATLTSQLS ANAHLVAAFE
KSLGNMTGRL QSLTMTAEQK ESELIELRET IEMLKAQNSA AQAAIQGALN GPDHPPKDLR
IRRQHSSESV SSINSATSHS SIGSGNDADS KKKKKKNWVN SRGSELRSSF KQAFGKKKST
KPPSSHSDIE ELTDSSLPAS PKLPHNGGDC GSASMKPSQS ASAICECTEA EAEIILQLKS
ELREKELKLT DIRLEALSSA HHLDQIREAM NRMQNEIEIL KAENDRLKAE TGNVGKPARP
PSESASSTSS SSSRQSLGLS LNNLNIAESV TSDILLDDPG DATGHKDGRS VKIIVSISKG
YGRAKDQKSQ AYLIGSIGVS GKTKWDVLDG VIRRLFKEYV FRIDTSASLG LSSDCIASYC
IGDVTRSHGP EVPELLPCGY LVGDNNVITV NLKGVEENSL DSFVFDTLIP KPITQRYFNL
LMEHHRIILS GPSGTGKTYL AHKLAEYVTT KSGRKKTEDA IATFNVDHKS SKELQQYLAN
LAEQCSADNN GAELPVVIIL DNLHHVGSLS DIFNGFLNCK YNKCPYIIGT MNQGVSSSPN
LELHHNFRWV LCANHTEPVK GFLGRYLRRK LIEMEIERNI RNNDLVKIID WIPKTWHHLN
SFLETHSSSD VTIGPRLFLP CPMDVEGSRV WFMDLWNYSL VPYILEAVRE GLQMYGKRAP
WEDPSKWVLD TYPWSSASLP QEGPALLQLR PEDVGYEGCI STKEATTSKH IPQADTEGDP
LMNMLMKLQE AANYSGTQSC DSDSTSHHED ILDSSLESTL
//
