ID A0A3Q1M8A2_BOVIN Unreviewed; 1553 AA.
AC A0A3Q1M8A2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 {ECO:0000313|Ensembl:ENSBTAP00000066337.1};
GN Name=PREX2 {ECO:0000313|Ensembl:ENSBTAP00000066337.1,
GN ECO:0000313|VGNC:VGNC:33312};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000066337.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000066337.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000066337.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000066337.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000066337.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSBTAT00000082175.1; ENSBTAP00000066337.1; ENSBTAG00000022169.5.
DR VEuPathDB; HostDB:ENSBTAG00000022169; -.
DR VGNC; VGNC:33312; PREX2.
DR GeneTree; ENSGT00940000155894; -.
DR Proteomes; UP000009136; Chromosome 14.
DR Bgee; ENSBTAG00000022169; Expressed in intramuscular adipose tissue and 83 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1M8A2; baseline.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:Ensembl.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:Ensembl.
DR GO; GO:0008344; P:adult locomotory behavior; IEA:Ensembl.
DR GO; GO:0048813; P:dendrite morphogenesis; IEA:Ensembl.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0043491; P:phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR CDD; cd04439; DEP_1_P-Rex; 1.
DR CDD; cd04440; DEP_2_P-Rex; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01224; PH_Collybistin_ASEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 2.30.42.10; -; 2.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR037367; Rex2_DEP_1.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22829; DEP DOMAIN PROTEIN; 1.
DR PANTHER; PTHR22829:SF1; PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE-DEPENDENT RAC EXCHANGER 2 PROTEIN; 1.
DR Pfam; PF00610; DEP; 2.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00049; DEP; 2.
DR SMART; SM00228; PDZ; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50156; PDZ domain-like; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS50186; DEP; 2.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50106; PDZ; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 1..162
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 193..309
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 338..412
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 445..514
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 540..589
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 625..684
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 1009..1028
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 145..172
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1012..1028
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1553 AA; 176726 MW; F29A8BC2DBBD750F CRC64;
MNQCAASKLD KNVTEETVKM LFSNIEDILA VHKEFLKAVE ECLHPEPNAQ QEVGTCFLQF
KDKFRIYDEY CSNHEKAQKL LFELNKIRTI RTFLLNCMLL GGRKNTDVPL EGYLVTPIQR
ICKYPLLLKE LLKRTPRKHS DYAALMEALQ AMKAVCSNIN EAKRQMEKLE VLEEWQSHIE
GWEGSNITDT CTEMLMCGVL LKISSGNIQE RVFFLFDNLL VYCKRKHRRL KNSKASTDGH
RYLFRGRINT EVMEVENVDD GTADFHSSGH IVVNGWKIHN TAKNKWFVCM AKTPEEKHEW
FEAILKERER RKGLKLGMEQ DTWVMISEQG EKLYKMMCKQ GNLIKDRKRK LTTFPKCFLG
SEFVSWLLEI GEIHRPEEGV HLGQALLENG IIHHVTDKHQ FKPEQMLYRF RYDDGTFYPR
NEMQDVISKG VRLYCRLHSL FTPVVRDKDY HLRTYKSVVM ANKLIDWLIA QGDCRSREEA
MIFGIGLCDN GFMHHVLEKS EFKDEPLLFR FFADEEMEGS NMKHRLMKHD LKVVENVIAK
SLLIKSNEGS YGFGLEDKNK VPIIKLVEKG SNAEMAGMEV GKKIFAINGD LVFMRPFNEV
DCFLKSCLNS RKPLRVLVST KPRETVKIPD SAEGLGFQIR GYGPSVVHAV GRGTVAAAAG
LHPGQCIIKV NGINVSKETH ASVIAHVTAC RKYRRPTKQD SIQWVYNSVE SAQEDLQKSN
SKPPGDEAGD SFDCKVEEVI DKFNTMAIID GKKEHVSLTV DNVHLEYGVV YEYDSTAGIK
CNVVEKMIEP KGFFSLTAKI LEALAKSDDH FVQNCTSLSS LNEVIPTDLQ SKFSAICSEK
IERICQRISS YKKFSRVLKN RAWPTFKQAK SRISPLHSSD FCPTNCHVNV MEVSYPKTST
SLGSAFGVQL DSRKHNSHDK ENKSEQGKLS PMVYIQHTIT TMAAPSGLSL GQQDGHGLRY
LLKEEDLETQ DIYQKLLGKL QTALKEVEMC VCQIDDLLSS ITYSPKLERK ASESIVPTDS
DNEKGERNSK RVCFNMAGDE QEDSGHDTIS NRDSYSDCNS NRNSVASFTS ICSSQCSSYF
HSDEMDSGDE LPLNVRISRD KQDKIHSCLE HLFSQVDSIT NLLRGQAVVR AFEQTKYLTP
GRGLQEFQQE MEPKLSCPKR LRLHIKQDPW NLPSSVRNLA QNIRRFVEEV KCRILLALLE
YSDSETQLRR DMVFCQSLVA TVCAFSEQLM AALNQMFDNS KENEMETWEA SRRWLDQIAN
AGVLFHFQSL LSPNLTDEQA MLEDTLVALF DLEKVSFYFK PSEEEPLVAN VPLTYQAEGS
RQALKIYFYI DSYHFEQLPQ RLKNGGGFKI HPVLFSQALE SMEGYYYRDN VSVEEFQAQI
NAASLEKVKQ YNQKLRAFYL DKSNSPPNST SKAAYIDKLM RPLNVLDELY RLVASFIRSK
RTAACVNTAC SASGVGLLSV SSELCSRLGA CHVIMCNSGV HRCTLSVTLE QAIILARSHG
LPPRYIMQAT DVMRKQGARV QNTAKNLGVR DRTPQSAPRL YKLCEPPPPV GEE
//
