ID A0A3Q1M8E4_BOVIN Unreviewed; 351 AA.
AC A0A3Q1M8E4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=MAPK activated protein kinase 2 {ECO:0000313|Ensembl:ENSBTAP00000070170.1};
GN Name=MAPKAPK2 {ECO:0000313|Ensembl:ENSBTAP00000070170.1,
GN ECO:0000313|VGNC:VGNC:54449};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000070170.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000070170.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000070170.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000070170.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000070170.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr
CC protein kinase family. {ECO:0000256|ARBA:ARBA00006692}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3Q1M8E4; -.
DR Ensembl; ENSBTAT00000068162.1; ENSBTAP00000070170.1; ENSBTAG00000038107.3.
DR VEuPathDB; HostDB:ENSBTAG00000038107; -.
DR VGNC; VGNC:54449; MAPKAPK2.
DR GeneTree; ENSGT00940000157261; -.
DR Proteomes; UP000009136; Chromosome 16.
DR Bgee; ENSBTAG00000038107; Expressed in longissimus thoracis muscle and 104 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1M8E4; baseline and differential.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR CDD; cd14170; STKc_MAPKAPK2; 1.
DR Gene3D; 4.10.1170.10; MAP kinase activated protein kinase 2; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR027442; MAPKAPK_C.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR24349:SF63; MAP KINASE-ACTIVATED PROTEIN KINASE 2; 1.
DR PANTHER; PTHR24349; SERINE/THREONINE-PROTEIN KINASE; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000256|RuleBase:RU000304};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Serine/threonine-protein kinase {ECO:0000256|RuleBase:RU000304};
KW Transferase {ECO:0000256|RuleBase:RU000304}.
FT DOMAIN 15..276
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 44
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 351 AA; 40461 MW; BCC63C43ADEFF2B3 CRC64;
MSLQIKKNAI IDDYKVTTQV LGLGINGKVL QIFSKRTQEK FALKMLQDCP KARREVELHW
RASQCPHIVR IVDVYENLYA GRKCLLIVME CLDGGELFSR IQDRGDQAFT EREASEIMKS
IGEAIQYLHS INIAHRDVKP ENLLYTSKRP NAILKLTDFG FAKETTSHNS LTTPCYTPYY
VAPEVLGPEK YDKSCDMWSL GVIMYILLCG YPPFYSNHGL AISPGMKSRI RMGQYEFPNP
EWSEVSEEVK MLIRNLLKTE PTQRMTITEF MNHPWIMQST KVPQTPLHTS RVLKEDKERW
EDVKEEMTSA LATMRVDYEQ IKIKKIEDAS NPLLLKRRKK ARALEAAALA H
//