ID   A0A3Q1M9W1_BOVIN        Unreviewed;       715 AA.
AC   A0A3Q1M9W1;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=acylaminoacyl-peptidase {ECO:0000256|ARBA:ARBA00012917};
DE            EC=3.4.19.1 {ECO:0000256|ARBA:ARBA00012917};
GN   Name=APEH {ECO:0000313|Ensembl:ENSBTAP00000067361.1,
GN   ECO:0000313|VGNC:VGNC:26010};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000067361.1, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000067361.1, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000067361.1,
RC   ECO:0000313|Proteomes:UP000009136};
RA   Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA   Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA   Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT   "ARS-UCD1.2.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000067361.1}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000067361.1};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Cleavage of an N-acetyl or N-formyl amino acid from the N-
CC         terminus of a polypeptide.; EC=3.4.19.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00000721};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   AlphaFoldDB; A0A3Q1M9W1; -.
DR   Ensembl; ENSBTAT00000072979.1; ENSBTAP00000067361.1; ENSBTAG00000011583.6.
DR   VEuPathDB; HostDB:ENSBTAG00000011583; -.
DR   VGNC; VGNC:26010; APEH.
DR   GeneTree; ENSGT00390000013172; -.
DR   Proteomes; UP000009136; Chromosome 22.
DR   Bgee; ENSBTAG00000011583; Expressed in digestive system secreted substance and 107 other cell types or tissues.
DR   ExpressionAtlas; A0A3Q1M9W1; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008242; F:omega peptidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR045550; AARE_N.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR002471; Pept_S9_AS.
DR   InterPro; IPR001375; Peptidase_S9.
DR   PANTHER; PTHR42776:SF4; ACYLAMINO-ACID-RELEASING ENZYME; 1.
DR   PANTHER; PTHR42776; SERINE PEPTIDASE S9 FAMILY MEMBER; 1.
DR   Pfam; PF19283; APEH_N; 1.
DR   Pfam; PF00326; Peptidase_S9; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF50993; Peptidase/esterase 'gauge' domain; 1.
DR   PROSITE; PS00708; PRO_ENDOPEP_SER; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT   DOMAIN          44..284
FT                   /note="Acylamino-acid-releasing enzyme N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF19283"
FT   DOMAIN          506..714
FT                   /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00326"
SQ   SEQUENCE   715 AA;  79512 MW;  0860332A7350DB93 CRC64;
     LERAVLLSEP EEAAALYRGL SRQPALSAAC LGPEVTTQYG GRYRTVHTEW TQRDLERMEN
     IRFCRQYLVF HDGDSVVFAG PAGNSVETRG ELLSRESPSG TMKAVLRKAG STGEEKQFLE
     VWEKNRKLKS FNLSALEKHG PVYEDDCFGC LSWSHSETHL LYVAEKKRPK AESFFQTKAL
     DISGSDDEMA RPKKPDQAIK GDQFLFYEDW GENMVSKGSP VLCVLDIESG NISVLEGVPE
     SVSPGQAFWA PGDTGVVFAG WWHEPFRLGI RFCTNRRSAL YYVDLTGGNC ELLSDDSLAV
     TSPRLSPDQC RIVYLQFPSL VPHQQCGQLC LYDWYTRVTV VVVDVVPRQL GENFSGIYCS
     LLPLGCWSAD SQRVVFDTAQ RSRQVRGGSG GSWKLLTIDR DLMVAQFSTP NLPPCLKVGF
     LPPAGMEQEV VWVSLEEAEP IPDISWSIRV LQPPPEQEHA QYVGLDFEAI LIQPSNPPDK
     TQVPMVVMPH GGPHSSFVTS WMLLPAMLCK MGFAALLVNY RGSTGFGQDS ILSLPGNVGS
     QDVKDVQFAV EQVLQEEHFD AGRVALLGGS HGGFLSCHLI GQYPETYGAC VVRNPVINIA
     SMMGSTDIPD WCVVEAGYLY SSDCLPDPNV WSEMLNKSPI KYTPQVKTPV LLMLGQEDRR
     VPFKQGMEYY RALKARNVPV RLLLYPKSTH SLSEVEVESD SFMNAVIWMC THLGH
//