ID A0A3Q1MA97_BOVIN Unreviewed; 708 AA.
AC A0A3Q1MA97;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Rho guanine nucleotide exchange factor 16 {ECO:0000313|Ensembl:ENSBTAP00000065452.1};
GN Name=ARHGEF16 {ECO:0000313|Ensembl:ENSBTAP00000065452.1,
GN ECO:0000313|VGNC:VGNC:26108};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000065452.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000065452.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000065452.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000065452.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000065452.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3Q1MA97; -.
DR SMR; A0A3Q1MA97; -.
DR STRING; 9913.ENSBTAP00000065452; -.
DR PaxDb; 9913-ENSBTAP00000027769; -.
DR Ensembl; ENSBTAT00000081198.1; ENSBTAP00000065452.1; ENSBTAG00000020837.6.
DR VEuPathDB; HostDB:ENSBTAG00000020837; -.
DR VGNC; VGNC:26108; ARHGEF16.
DR GeneTree; ENSGT01030000234571; -.
DR InParanoid; A0A3Q1MA97; -.
DR OMA; FHPYVVY; -.
DR OrthoDB; 12272at2759; -.
DR Reactome; R-BTA-193648; NRAGE signals death through JNK.
DR Reactome; R-BTA-416482; G alpha (12/13) signalling events.
DR Reactome; R-BTA-9013148; CDC42 GTPase cycle.
DR Reactome; R-BTA-9013408; RHOG GTPase cycle.
DR Proteomes; UP000009136; Chromosome 16.
DR Bgee; ENSBTAG00000020837; Expressed in abomasum and 92 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1MA97; baseline and differential.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd01221; PH_ephexin; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11938; SH3_ARHGEF16_26; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035797; ARHGEF16/ARHGEF26_SH3.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR047271; Ephexin-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR047270; PH_ephexin.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12845; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR12845:SF3; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 16; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 283..467
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 500..619
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 628..688
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 25..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 90..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 179..245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..242
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 708 AA; 79613 MW; D302A30E17357D7C CRC64;
MSQRYSDSSV EEKLLEYRFH SELRLDAKGN PASGLPVVRG SLHSGSNAAF QPDTLAPPEP
APESQEPRTV ILSTQSPAAL KMGTQQLIPR SLAVSSKSKT PARHQSFGAA MLSKEAARRN
PQLLSAPSFS LDDMDLDTGP GGMLKRNLRN QSYRAAMKGL GTPGGEGGPI QLTPKLQALA
EEPSQPPARP AAKNKKTLGR KRAHKGSFKD DPRLYQEIRE RGLNTSHESD DDLLDEPPSP
EGTRKVDAPI VVKSYRPPQI TWSQLPEVVE SGILDQLPAE ERKRQEAIFE ILTSEFSYQH
SLGILVAEFL QSRALRATMT QMEHHHLFSN ITDVLSASQR FFEDLERRHK AQVCVEDISD
ILEEHAEHHF HPYISYCSNE VYQQRALQRL TNSNATFREA LRAIEQRPAC GGLPMISFLI
LPMQRVTRLP LLTDTLCLKT QGHPERYKAA SRALKAISKL VKQCNEGAHK MERTEQMYTL
HTQLDFSKVK SLPLISASRW LLKRGELFVV EETGLFRKLA SRPTCYLFLF NDVLVVTKRK
SEDSFMVQDY AQVDHIQVQK MEPSEASLPG GGNRGSSVPH PFQLILLHNS EGRQEKILLS
CDSASDRARW ITALTQRERQ ARGPPNKGDL LQVEITKAYL AKQVDEITLQ QADVVLILEQ
EDGWLYGERL RDGETGWFPE DFARSITSRV AVEGNVRRME RLRVETDV
//
