ID A0A3Q1MBT7_BOVIN Unreviewed; 744 AA.
AC A0A3Q1MBT7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Pendrin {ECO:0000256|RuleBase:RU362052};
DE AltName: Full=Sodium-independent chloride/iodide transporter {ECO:0000256|RuleBase:RU362052};
DE AltName: Full=Solute carrier family 26 member 4 {ECO:0000256|RuleBase:RU362052};
GN Name=SLC26A4 {ECO:0000313|Ensembl:ENSBTAP00000067775.1,
GN ECO:0000313|VGNC:VGNC:34779};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000067775.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000067775.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000067775.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000067775.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000067775.1};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- FUNCTION: Sodium-independent transporter of chloride and iodide.
CC {ECO:0000256|RuleBase:RU362052}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000256|RuleBase:RU362052}.
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DR AlphaFoldDB; A0A3Q1MBT7; -.
DR Ensembl; ENSBTAT00000084916.1; ENSBTAP00000067775.1; ENSBTAG00000010062.6.
DR VEuPathDB; HostDB:ENSBTAG00000010062; -.
DR VGNC; VGNC:34779; SLC26A4.
DR GeneTree; ENSGT01070000253775; -.
DR Proteomes; UP000009136; Chromosome 4.
DR Bgee; ENSBTAG00000010062; Expressed in saliva-secreting gland and 20 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1MBT7; baseline.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0098661; P:inorganic anion transmembrane transport; IEA:UniProtKB-UniRule.
DR CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR PANTHER; PTHR11814:SF33; PENDRIN; 1.
DR PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
DR PROSITE; PS50801; STAS; 1.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|RuleBase:RU362052};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362052};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT TRANSMEM 149..175
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 181..203
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 210..227
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 233..251
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 263..280
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 313..336
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 348..370
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 385..405
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 442..474
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT DOMAIN 498..693
FT /note="STAS"
FT /evidence="ECO:0000259|PROSITE:PS50801"
FT REGION 571..590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 744 AA; 81811 MW; 97AE91AE782A696C CRC64;
MAAPGDRLEP PPLPEYSCSY VVSRPVYNEL AFQQQYEQRP KERKTLRENL AQGCSCSRKR
TLRMVKTLLP ILDWLPKYRI KEWLLSDIIS GVSTGLVGTL QGPFPVVSLM VGSVVLSMAP
DEHFLVSSSN GTALNTTIID FAARDAARVL IASTLTLLVG IIQLIFGGLQ IGFIVRYLAD
PLVGGFTTAA AFQVLVSQLK IVLNVSTKNY NGILSIIYTL IEIFQNISNT NLADFIAGLL
TIIICMAVKE LNDRFKHKIP VPIPIEVIVT IAATAISYGV DLEKKYNAGI VKSIPSGFLP
PAMPSVSLFS EMLTASFSIS VVAYAIAVSV GKVYAIRHDY TIDGNQESIA FGISNIFSGL
FSCFVATTAL SRTAVQESTG GKTQVAGIIS AGVVMIAIVA LGKLLEPLQK SVLAAVVIAN
LKGMFMQVCD VPHLWRQNKT DAVIWVFTCM ASIILGLDLG LLAGLVFGFL TVVLRVQFPS
WNSLGSIPST DIYKSTKNYK NIEELEGVKI LRFSSPIFYG NVDGLKKCIK STVGFDAIRV
YNKRLKALRK IQKLIKKGQL RATKNGIISG AGSSNNAFEP DEDIENPEEP DIPTKEIEIQ
VDWNSELPVK VNVPKVPIHS LVLDCGAVSF LDVVGVRSLR VIVKEFQRID VNVYFASLQD
HVIEKLEKCG FFNDNNIRKD IFFMTVHDAV LHLQNQVKSQ EVQDSILETI TLIQDCKDPL
ELMEAEMIEE QLDVQDEAIR RLAS
//