ID A0A3Q1MD89_BOVIN Unreviewed; 751 AA.
AC A0A3Q1MD89;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Two pore segment channel 2 {ECO:0000313|Ensembl:ENSBTAP00000068367.1};
GN Name=TPCN2 {ECO:0000313|Ensembl:ENSBTAP00000068367.1,
GN ECO:0000313|VGNC:VGNC:36244};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000068367.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000068367.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000068367.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000068367.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000068367.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; NP_001179380.1; NM_001192451.1.
DR AlphaFoldDB; A0A3Q1MD89; -.
DR PaxDb; 9913-ENSBTAP00000020205; -.
DR Ensembl; ENSBTAT00000068542.1; ENSBTAP00000068367.1; ENSBTAG00000015183.5.
DR GeneID; 516679; -.
DR KEGG; bta:516679; -.
DR CTD; 219931; -.
DR VEuPathDB; HostDB:ENSBTAG00000015183; -.
DR VGNC; VGNC:36244; TPCN2.
DR GeneTree; ENSGT00940000159763; -.
DR OMA; FTESIEM; -.
DR OrthoDB; 5403296at2759; -.
DR Proteomes; UP000009136; Chromosome 29.
DR Bgee; ENSBTAG00000015183; Expressed in monocyte and 103 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1MD89; baseline.
DR GO; GO:0005765; C:lysosomal membrane; IEA:InterPro.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0022832; F:voltage-gated channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 2.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 2.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR028798; TPC2.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR46768; TWO PORE CALCIUM CHANNEL PROTEIN 2; 1.
DR PANTHER; PTHR46768:SF1; TWO PORE CHANNEL PROTEIN 2; 1.
DR Pfam; PF00520; Ion_trans; 2.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 77..100
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 159..180
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 220..240
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 289..312
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 433..455
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 467..486
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 507..526
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 581..605
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 671..693
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 87..315
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 432..696
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 751 AA; 86009 MW; 7573ACE80AEDB186 CRC64;
MADTLEESEP LLSRARGGSG RDCPRGVLTC SSVQESPGAA ARRDLCLDQA VVLIEDAIQY
RSINHRMDAR SLWLYRWYYS SSSQWILSFT IFLILALAFV ETPSSLTRTS DVRYRPAPWE
PPCGLTEGVE ALCLLVFVAD VSVKSYLIGW AQFRRNPWLL AYLVVLVASL LDWTVSLSLV
CQEPLRVRRL LRPFFLMQNS SMMKKTLKCI RRSLPEMASV GLLLAVHLCL FTVFGMLLFT
GEKDAGQDRE RLTYFFNLPE ALTTLLVLLT TANNPDVMIP VYSRNRAYAI FFIAFTLIGS
LFLMNLMTAI IYNQFRGYLM MSLQTSLLRR RLGTRAAYEV LSSVTAEGEA HPKRLGVKPE
DFLQVLQKVQ LDSDHKQAIT EKLHSRGDGL LSTDEFQKLF YEFDKRVIKE HPPRPEYQSP
FLRSTQFLFG HHYFDYLGNL MALGNLVTIC VFLVLDAHVL PKDRDDFVLG ILNCIFILYY
LLEMLLKVFS LGLQGYLSYS SNVFDGLLTI VLLVLEISTL AEYGFPHRGW KPATLGLLSL
WDMTRLVNVL IVFRFLRIIP SMQLMSLVAS TILDLIKNMR AFGGILVVIY YVFAIIGISL
FQGVIVAPRN SSLASVNGSA PCGSFEQLEY WPNNFDDFAA ALVTLWDVMI VNNWQVFLDA
FRRYAGPWSE VYFVLWWLVS SVIWVNLFLA LILENFLHKW DRRSHLQSFT QELEDTSEMT
QELPFRDVLE EPTEEELVEK LSRHPHLQLC R
//
