ID   A0A3Q1MDD8_BOVIN        Unreviewed;       529 AA.
AC   A0A3Q1MDD8;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Ectonucleoside triphosphate diphosphohydrolase 3 {ECO:0000313|Ensembl:ENSBTAP00000068423.1};
GN   Name=ENTPD3 {ECO:0000313|Ensembl:ENSBTAP00000068423.1,
GN   ECO:0000313|VGNC:VGNC:28510};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000068423.1, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000068423.1, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000068423.1,
RC   ECO:0000313|Proteomes:UP000009136};
RA   Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA   Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA   Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT   "ARS-UCD1.2.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000068423.1}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000068423.1};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
CC       {ECO:0000256|ARBA:ARBA00009283, ECO:0000256|RuleBase:RU003833}.
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DR   AlphaFoldDB; A0A3Q1MDD8; -.
DR   Ensembl; ENSBTAT00000068980.1; ENSBTAP00000068423.1; ENSBTAG00000011702.6.
DR   VEuPathDB; HostDB:ENSBTAG00000011702; -.
DR   VGNC; VGNC:28510; ENTPD3.
DR   GeneTree; ENSGT01100000263542; -.
DR   OMA; GNAISDM; -.
DR   OrthoDB; 180318at2759; -.
DR   Proteomes; UP000009136; Chromosome 22.
DR   Bgee; ENSBTAG00000011702; Expressed in corpus epididymis and 73 other cell types or tissues.
DR   ExpressionAtlas; A0A3Q1MDD8; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0017110; F:nucleoside diphosphate phosphatase activity; IEA:Ensembl.
DR   GO; GO:0017111; F:ribonucleoside triphosphate phosphatase activity; IEA:Ensembl.
DR   GO; GO:0009134; P:nucleoside diphosphate catabolic process; IEA:Ensembl.
DR   GO; GO:0009143; P:nucleoside triphosphate catabolic process; IEA:Ensembl.
DR   Gene3D; 3.30.420.40; -; 1.
DR   Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR   InterPro; IPR000407; GDA1_CD39_NTPase.
DR   PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1.
DR   PANTHER; PTHR11782:SF38; ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 3; 1.
DR   Pfam; PF01150; GDA1_CD39; 1.
DR   PROSITE; PS01238; GDA1_CD39_NTPASE; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW   Hydrolase {ECO:0000256|RuleBase:RU003833};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        21..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        486..510
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   ACT_SITE        182
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600407-1"
FT   BINDING         222..226
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600407-2"
SQ   SEQUENCE   529 AA;  59312 MW;  467F10BD3C20DD88 CRC64;
     MFTVLTRQPC EQAGLKVLSR TPAIIALVVL FLSIVVLMAI TLIQTHQKEV LFPGPKYGIV
     LDAGSSRTTI YVYQWPAEKA NNTGVVSQSF KCNVKGSGIS NYAENPQDAP KAFEDCMQKV
     KGHIPVSLHG STCVYLGATA GMRLLRLQNE TAANEVLESI ENYFKSQPFD FRDAQIISGQ
     EEGIYGWITA NYLMGNFLEK SLWHMWVHPS GKETTGALDL GGASTQISFA AEEKVGLNTS
     DIMKVTLYGY EYTLYTHSFQ CYGRNEAEKR FLATLLQDYT TETTLTNPCY PQNYITTFTE
     AQVFGSLCTE DLRPERYNPN NTITFEGTGD PSLCREKVAS LFNFSACHDH EACSFDGVYQ
     PRVKGSFVAF AGFYYTANAF NLSGSFSLHA FNLSTWNFCS KNWNQLPLLL PQFDEQYARS
     YCFSAHYIYH LLVSGYKFTE ESWPQIHFKK EVGNSSIAWS LGYMLSLTNQ IPAESPLIRL
     PIKPSAFVGT LAFFAAVALL CLTYLVYLCV LSRNQRRSQH ALDNMVDSE
//