ID A0A3Q1MFD4_BOVIN Unreviewed; 1813 AA.
AC A0A3Q1MFD4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=SET binding factor 1 {ECO:0000313|Ensembl:ENSBTAP00000069236.1};
GN Name=SBF1 {ECO:0000313|Ensembl:ENSBTAP00000069236.1,
GN ECO:0000313|VGNC:VGNC:34305};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000069236.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000069236.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000069236.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000069236.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000069236.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR Ensembl; ENSBTAT00000076654.1; ENSBTAP00000069236.1; ENSBTAG00000021337.6.
DR VEuPathDB; HostDB:ENSBTAG00000021337; -.
DR VGNC; VGNC:34305; SBF1.
DR GeneTree; ENSGT00940000155263; -.
DR Proteomes; UP000009136; Chromosome 5.
DR Bgee; ENSBTAG00000021337; Expressed in blood and 104 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1MFD4; baseline.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR CDD; cd01235; PH_Sbf1_hMTMR5; 1.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR022096; SBF1/SBF2.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR PANTHER; PTHR10807:SF43; MYOTUBULARIN-RELATED PROTEIN 5; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF02893; GRAM; 1.
DR Pfam; PF06602; Myotub-related; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF12335; SBF2; 2.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00568; GRAM; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00800; uDENN; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 7..439
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT DOMAIN 1043..1542
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51339"
FT DOMAIN 1707..1811
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 101..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 950..972
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 988..1038
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1211..1240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1551..1579
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1669..1702
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1021..1038
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1813 AA; 201994 MW; B91BEF89290BA308 CRC64;
MARLADYFVL VAFGPHPRGS GEGQGQILQR FPEKDWEDNP FPQGIELFCQ PSGWQLCPER
NPPTFFVAVL TDINSERHYC ACLTFWEPVE PTQEELCARD AAERDEEANE GGPGALPPPT
PSPPGQLFAP KTLVLVSRLD HVEVFRNSLG LIYTIHVEGL NVGLENVVGN LLTCVIPLAG
GSQRTISLGA GDRQVIQTPL TDSLPISRCS VALLFRQLGI TNVLSLFCAA LTEHKVLFLS
RSYQRLSDAC RGLLALLFPL RYSFTYVPIL PAQLLEVLST PTPFIIGVNA AFQAEAQELL
DVIVADLDGG TVTVPECVHI PPLPEPLQSQ THSILSMVLD PELELADLAF PPPTTSISSL
KMQDKELRAV FLRLFAQLLQ GYRWCLHMVR IHPEPVIRFH KAAFLGQRGL VEDDFLMKVL
EGMAFAGFVS ERGVPYRPTD LFDELVAHEV ARMRADENHP QRVLRHVKEL AEQLYKNENP
YPAVAMHKVQ RPGEASHLRR APRPFPRLDE GMVQWIVDQA TAKMQGAPPA VKAEKRTTVP
SGPPMTAIVE RSGGLHGNSA RRLEVVRNCI SYVFEGKMLE AKKLLPAVLR ALKGRAARRC
LAQELHLHVQ QNRAVLDHQQ FDFVVRMMNC CLQVGEAPVQ EDERSALDVA SEQRRLWPTL
SREKQQELVQ KEESTVFSQA IHYANRMSYL LLPLDSSKSR LLRERAGLGE LESASNSLVT
NSMAGSVAES YDTESGFEDA ETCDVAGAVV RFINRFVDKV CTESGVTSDH LKGLHVMVPD
IVQMHIETLE AVHRESKRLP PIQKPKLLRP RLLPGEECVL DGLRVYLLPD GREEGAGGPG
GGPALLPAEG AVFLTTYRVI FTGMPTDPLV GEQVVVRSFP VAALTKEKRV SVQTPVDQLL
QDGLQLRSCT FQLLKMAFDE EVGSDSAELF RKQLHKLRYP PDIRGTFALS LGSAHTPGRP
PRANKDKGPS FRTLSRNLVK NAKKTIGRQY VTRKKYNPPS WEHRGQPPPE DQEDEISVSE
ELEPSTLTPS SALKPSDRMT MSSLVERACC RDYQRLGLGT LSSSLSRAKS EPFRISPVNR
MYAICRSYPG LLIVPQSVQD NALQRVSRCY RQNRFPVVCW RSGRSKAVLL RSGGLHGKGV
VGLFKAQNAP SPGQSQADSS SLEQEKYLQA VVSSMPRYAD ASGRNTLSGF SSAHMGSHVP
SPRARVTTLS NPMAASASRR TAPRGKWGSV RASGRSGGLS TDVGSRLAGV GPPQANGAPP
EPGFLRPQRA ALYIIGDKAQ LKGVRPDPLQ QWELVPIEVF EARQVKASFK KLLKACVPGC
PATEPSPASF LRSLEDSEWL IQIHKLLQVS VLVVELLDSG SSVLVSLEDG WDITTQVVSL
VQLLSDPFYR TLEGFRLLVE KEWLSFGHRF SHRGAHTLAG QSSGFTPVFL QFLDCVHQIH
LQFPMEFEFS PFYLKFLGYH HVSRRFRTFL LDSDYERIEL GLLYEEKGDR RAPQACRSVW
EYVERLSKRT PVFYNYMYAP EDAEVLRPYS NVSNLKVWDF YTEETLAEGP PYDWELAQGP
PEPPEEERPD GGAPQSRRRV VWPCYDSRPR AQPDAISRLL EEMQRLETEL GRPPERWKDA
WDRVKAAQRL EGRPDGRGTP SSLLVSSVPH HRRSLGVYLQ EGPVGSTLSL SLDSDQSSGS
TASSSRQAAR RSTSTLYSQF QTAESENRSY EGTLYKKGAF MKPWKARWFV LDKTKHQLRY
YDHRADTECK GVIDLAEVEA VAPGTPAMGA PKTVDEKAFF DVKTTRRVYN FCAQDVPSAQ
QWVDQIQSCL SDA
//
