ID A0A3Q1MG91_BOVIN Unreviewed; 1009 AA.
AC A0A3Q1MG91;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Signal peptide, CUB domain and EGF like domain containing 3 {ECO:0000313|Ensembl:ENSBTAP00000073264.1};
GN Name=SCUBE3 {ECO:0000313|Ensembl:ENSBTAP00000073264.1,
GN ECO:0000313|VGNC:VGNC:34373};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000073264.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000073264.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000073264.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000073264.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000073264.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_005196620.1; XM_005196563.3.
DR RefSeq; XP_005223362.1; XM_005223305.3.
DR AlphaFoldDB; A0A3Q1MG91; -.
DR STRING; 9913.ENSBTAP00000073264; -.
DR Ensembl; ENSBTAT00000068477.1; ENSBTAP00000073264.1; ENSBTAG00000009226.6.
DR GeneID; 100300124; -.
DR CTD; 222663; -.
DR VEuPathDB; HostDB:ENSBTAG00000009226; -.
DR VGNC; VGNC:34373; SCUBE3.
DR GeneTree; ENSGT00940000153185; -.
DR InParanoid; A0A3Q1MG91; -.
DR OMA; TCALSCP; -.
DR OrthoDB; 5477406at2759; -.
DR Reactome; R-BTA-1474228; Degradation of the extracellular matrix.
DR Proteomes; UP000009136; Chromosome 23.
DR Bgee; ENSBTAG00000009226; Expressed in thyroid gland and 84 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1MG91; baseline.
DR GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00054; EGF_CA; 3.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR24046; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24046:SF2; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF07699; Ephrin_rec_like; 3.
DR Pfam; PF14670; FXa_inhibition; 3.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00181; EGF; 10.
DR SMART; SM00179; EGF_CA; 8.
DR SMART; SM01411; Ephrin_rec_like; 4.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 4.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 5.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 5.
DR PROSITE; PS01187; EGF_CA; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1009
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018557684"
FT DOMAIN 29..69
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 112..148
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 293..333
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 334..372
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 373..414
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 820..932
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 338..348
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1009 AA; 110981 MW; CFDEBC0DDB632DAC CRC64;
MGSGRVPGLC LLVLLVHARA AQHSKAVQDV DECVEGTDNC HIDAICQNTP RSYKCICKSG
YTGDGKHCKD VDECEREDNA GCVHDCVNIP GNYRCTCYDG FHLAHDGHNC LDVDECAEGN
GGCQQSCVNM MGSYECHCRE GFFLSDNQHT CIQRPEEGMN CMNKNHGCAH ICRETPKGGI
ACECRPGFEL TKNQRDCKLT CNYGNGGCQH TCDDTEQGPR CGCHVKFVLH TDGKTCIGER
RLEQHVPPQA VSNETCAVNN GGCDSKCHDA ATGVHCSCPV GFMLQPDRKT CKDIDECRLN
NGGCDHICRN TVGSFECSCK KGYKLLINER NCQDIDECSF DRTCDHICVN TPGSFQCLCR
HGYLLYGVTH CGDVDECSIN RGGCRFGCVN TPGSYQCTCP AGQGRLHWNG KDCTEPVKCQ
SSPGASKAML SCNRSGKKDT CALTCPSRAR FLPESENGFT VSCGIPSPRA APARASHAGN
STNSNHCHEA AVLTVKQRAS FKIKDAKCHL HLRNKGKTEE TSRITGPGGA PCSDCQVTFI
HLKCDSSRKG KGRRARTPPG KEVTRLTLEL EAEVRAEETT AGCGLPCLRQ RMERRLKGSL
KMLRKSINQD RFLLRLAGLD YELAHKPGPV AGERVEPVEA CRPGQHRSGA KCVSCPQGTY
YHGQTEQCVP CPAGTFQERE GQLSCDLCPG SDAHGPLGAT NVTTCAGQCS PGQHSADGFK
PCQPCPRGTY QPEAGRTLCF PCGGGLTTKH EGAISFQDCD TKVQCSPGHY YNTSIHRCIR
CAMGSYQPDF RQNFCTRCPG NTSTDFDGST SVTQCKNRQC GGELGEFTGY IESPNYPGNY
PAGVECVWNI NPPPKRKILI VVPEIFLPSE DECGDVLVMR KNSSPSSITT YETCQTYERP
IAFTARSRKL WINFKTSEAN SARGFQIPYV TYDEDYEQLV EDIVRDGRLY ASENHQEILK
DKKLIKAFFE VLAHPQNYFK YTEKHKEMLP KSFIKLLRSK VSSFLRPYK
//
