ID A0A3Q1MGT2_BOVIN Unreviewed; 783 AA.
AC A0A3Q1MGT2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Sp4 transcription factor {ECO:0000313|Ensembl:ENSBTAP00000068243.1};
GN Name=SP4 {ECO:0000313|Ensembl:ENSBTAP00000068243.1,
GN ECO:0000313|VGNC:VGNC:35155};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000068243.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000068243.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000068243.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000068243.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000068243.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3Q1MGT2; -.
DR SMR; A0A3Q1MGT2; -.
DR STRING; 9913.ENSBTAP00000068243; -.
DR PaxDb; 9913-ENSBTAP00000019135; -.
DR Ensembl; ENSBTAT00000078710.1; ENSBTAP00000068243.1; ENSBTAG00000014389.6.
DR VEuPathDB; HostDB:ENSBTAG00000014389; -.
DR VGNC; VGNC:35155; SP4.
DR GeneTree; ENSGT00940000157827; -.
DR InParanoid; A0A3Q1MGT2; -.
DR OMA; NQQAILP; -.
DR OrthoDB; 5396935at2759; -.
DR Proteomes; UP000009136; Chromosome 4.
DR Bgee; ENSBTAG00000014389; Expressed in thymus and 100 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1MGT2; baseline.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd22536; SP4_N; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 3.
DR InterPro; IPR039938; Sp4-like.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR14947:SF21; C2H2-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR14947; ZINC FINGER PROTEIN; 1.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 646..675
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 676..705
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 706..733
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 1..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 109..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 279..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..50
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 783 AA; 81862 MW; 188378EC0F3676B2 CRC64;
MSDQKKEEEE EAAQAAAMAT EGGKTSEPEN NNKKPKTSGS QDSQPSPLAL LAATCSKIGT
PGENQATGQQ QIIIDPSQGL VQLQNQPQQL ELVTTQLAGN AWQLVASTPP ASKENNISQP
ASSSSSSSTS NNGSASPTKT KSGNSSSPGQ FQVIQVQNPS GSVQYQVIPQ LQTVEGQQIQ
INPTSSSSLQ DLQGQIQLIS AGNNQAILTA ANRTASGNIL AQNLANQTVP VQIRPGVSIP
LQLQTLPGTQ AQVVTTLPIN IGGVTLALPV INSVAAGGGT AQVGQPATTT ESGTSNGSQL
ASTPTTTTAS ASMPESPSSS TTCTTTASTS LTSSDTLVSS ADTGQYASTS ASSSERTVED
SQTPAATESE AQSSSQLQSN GIQNTQDQSN SLQQVQIVGQ PILQQIQIQQ PQQQIIQAIP
PQSFQLQSGQ TIQTIQQQPL QNVQLQAVNP TQVLIRAPTL TPSGQISWQT VQVQNIQSLS
NLQVQNAGLS QQLTITPVSS SGGTTLAQIA PVAVAGAPIT LNTAQLASVP NLQTVSVANL
GAAGVQVQGV PVTITSVAGQ QQGQDGVKVQ QATIAPVTVA VGGIANATIG AVSPDQLTQV
HLQQGQQASD QEVQPGKRLR RVACSCPNCR EGEGRGSNEP GKKKQHICHI EGCGKVYGKT
SHLRAHLRWH TGERPFICNW MFCGKRFTRS DELQRHRRTH TGEKRFECPE CSKRFMRSDH
LSKHVKTHQN KKGGGTALAI VTSGELDSSV TEVLGSPRIV TVAAISQDSN PATPNVSTNM
EEF
//
