ID A0A3Q1MIB0_BOVIN Unreviewed; 1583 AA.
AC A0A3Q1MIB0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=IQ motif containing GTPase activating protein 1 {ECO:0000313|Ensembl:ENSBTAP00000070448.1};
GN Name=IQGAP1 {ECO:0000313|Ensembl:ENSBTAP00000070448.1,
GN ECO:0000313|VGNC:VGNC:30258};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000070448.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000070448.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000070448.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000070448.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000070448.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSBTAT00000076125.1; ENSBTAP00000070448.1; ENSBTAG00000013060.6.
DR VEuPathDB; HostDB:ENSBTAG00000013060; -.
DR VGNC; VGNC:30258; IQGAP1.
DR GeneTree; ENSGT00950000183076; -.
DR Proteomes; UP000009136; Chromosome 21.
DR Bgee; ENSBTAG00000013060; Expressed in neutrophil and 110 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1MIB0; baseline and differential.
DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl.
DR GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
DR GO; GO:0030864; C:cortical actin cytoskeleton; IEA:Ensembl.
DR GO; GO:0036464; C:cytoplasmic ribonucleoprotein granule; IEA:Ensembl.
DR GO; GO:0009898; C:cytoplasmic side of plasma membrane; IEA:Ensembl.
DR GO; GO:0005925; C:focal adhesion; IEA:Ensembl.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:Ensembl.
DR GO; GO:0005874; C:microtubule; IEA:Ensembl.
DR GO; GO:0030496; C:midbody; IEA:Ensembl.
DR GO; GO:0043005; C:neuron projection; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:Ensembl.
DR GO; GO:0001726; C:ruffle; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
DR GO; GO:0005516; F:calmodulin binding; IEA:Ensembl.
DR GO; GO:0005078; F:MAP-kinase scaffold activity; IEA:Ensembl.
DR GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IEA:Ensembl.
DR GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0019903; F:protein phosphatase binding; IEA:Ensembl.
DR GO; GO:0043539; F:protein serine/threonine kinase activator activity; IEA:Ensembl.
DR GO; GO:0044548; F:S100 protein binding; IEA:Ensembl.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR GO; GO:0071277; P:cellular response to calcium ion; IEA:Ensembl.
DR GO; GO:0071364; P:cellular response to epidermal growth factor stimulus; IEA:Ensembl.
DR GO; GO:0036120; P:cellular response to platelet-derived growth factor stimulus; IEA:Ensembl.
DR GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0010761; P:fibroblast migration; IEA:Ensembl.
DR GO; GO:0035305; P:negative regulation of dephosphorylation; IEA:Ensembl.
DR GO; GO:1990138; P:neuron projection extension; IEA:Ensembl.
DR GO; GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0001817; P:regulation of cytokine production; IEA:Ensembl.
DR GO; GO:0007346; P:regulation of mitotic cell cycle; IEA:Ensembl.
DR CDD; cd05133; RasGAP_IQGAP1; 1.
DR CDD; cd00201; WW; 1.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 4.10.270.10; Myosin, subunit A; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000593; RasGAP_C.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001202; WW_dom.
DR PANTHER; PTHR14149; RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF; 1.
DR PANTHER; PTHR14149:SF15; RAS GTPASE-ACTIVATING-LIKE PROTEIN IQGAP1; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00612; IQ; 4.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF03836; RasGAP_C; 1.
DR SMART; SM00033; CH; 1.
DR SMART; SM00015; IQ; 4.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF143885; RGC domain-like; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS50096; IQ; 4.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A3Q1MIB0};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 1..109
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 619..646
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 938..1171
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT COILED 118..145
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 432..459
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1583 AA; 180838 MW; DE95400D6C2619A4 CRC64;
SEWMEACLGE DLPPTTELEE GLRNGVYLAK LGNFFSPKVV SLKKIYDREQ TRYKATGLHF
RHTDNVIQWL NAMGEIGLPK IFYPETTDIY DRKNMPRCIY CIHALSLYLF KLGLAPQIQD
LYGKVDFTEE EINNMKIELE KYGIQMPAFS KIGGILANEL SVDEAALHAA VIAINEAIDH
RIPADTFTAL KNPNAMLVNL EECLASTYQD ILYQAKQDKM ANAKNRRERD VYEELLTQAE
IQGNINKVNL LAALTNIDLA LEQGSAPALF KILQSPALGL RGLQQQNSDW YLKQLLSDRQ
QKRQGGQAEP LQKEELQSGV DAANTAAQEY QRRLAAVAAI NAAIQKGVAE KTVLELMNPE
AQLPQVYPFA ADLYQKELAT LQQQSPEHSL THPELSVAVE MLSSVALINR ALESGDMNTV
WKQLSSSVTG LTNIEEENCQ RYLDELMKLK AQARAENNEF ITWNDIQASV DHVNRVVQEE
HERILAIGLI NEALDEGDAQ KTLQALQIPA AKLEGVLSEV AQHYQDTLIR AKREKAQETQ
DESAVLWLDE IQGGIWQSNK DTQEAQRFAL GIFAINEAVE KGDVGKTLSA LRSPDVGLYG
VIPECGETYQ SDLCGSDKWV KHWVKGGYHY YHNLETQEGG WDEPSDFVQN SMQLSREEIQ
SSISGVTAAY NREQLWLANE GLITKLQACC RGYLVRQEFR SRMNFLKKQI PAITCIQSQW
RGYKQKKAYQ DRLAYLRSHK DEVIKIQSLA RMHQARKRYR ERLQYFRDHI NDIIKIQAFI
RANKARDDYK TLINAEDPPM IVVRKFVHLL DQSDQDFQEE LDLMKMREEV ITLIRSNQQL
ENDLNLMDIK IGLLVKNKIT LQDVVSHSKK LTKKNKEQLS DMMMLNKQKG GLKALSKEKR
EKLEAYQHLF YLLQTNPTYL AKLIFQMPQN KSTKFMDSVI FTLYNYASNQ REEYLLLRLF
KTALQEEIKS KVDQIQEIVT GNPTVIKMVV SFNRGARGQN ALRQILAPVV KEIMDDKTLN
IKTDPVDIYK SWVNQMESQT GEASKLPYDV TPEQALSHEE VRTRLDNSIR NMRAVTDKFL
AAIISSVDKI PYGMRFIAKV LKDSLHEKFP DAGEDELLKI IGNLLYYRYM NPAIVAPDAF
DIIDLSAGGQ LTTDQRRNLG SIAKMLQHAA SNKMFLGDNA HLSIINEYLS QSYQKFRRFF
QTACDVPELQ DKFNVDEYSD LVTLTKPVIY ISIGEIINTH TLLLDHQDAI APEHNDPIHE
LLDDLGEVPT IESLIGAGNL NDPNKEALAK TEVSLTLTNK FDVPGDENAE MDARTILLNT
KRLIVDVIRF QPGETLTEIL ETPATSEQEA EHQRAMQRRA IRDAKTPDKM KKSKTIKEDS
SLSLQEKKEK IQSGLKKLTE LGTVDPKNRY QELINDIARD IRNQRRYRQR RKAELVKLQQ
TYAALNSKAT FYGEQVDYYK SYIKTCLDNL ASKGKEMKGK KSKKISLKYT AARLHEKGVL
LEIEDLQVNQ FKNVIFEISP TEEVGDFEVK AKFMGVQMET FMLHYQDLLQ LQYEGVAVMK
LFDRAKVNVN LLIFLLNKKF YEK
//
