ID A0A3Q1MII4_BOVIN Unreviewed; 998 AA.
AC A0A3Q1MII4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=116 kDa U5 small nuclear ribonucleoprotein component {ECO:0000256|ARBA:ARBA00018774};
DE AltName: Full=U5 snRNP-specific protein, 116 kDa {ECO:0000256|ARBA:ARBA00031432};
GN Name=EFTUD2 {ECO:0000313|Ensembl:ENSBTAP00000068978.1,
GN ECO:0000313|VGNC:VGNC:28364};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000068978.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000068978.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000068978.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000068978.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000068978.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A3Q1MII4; -.
DR SMR; A0A3Q1MII4; -.
DR Ensembl; ENSBTAT00000085361.1; ENSBTAP00000068978.1; ENSBTAG00000013526.5.
DR VEuPathDB; HostDB:ENSBTAG00000013526; -.
DR VGNC; VGNC:28364; EFTUD2.
DR GeneTree; ENSGT00940000155685; -.
DR InParanoid; A0A3Q1MII4; -.
DR Reactome; R-BTA-72163; mRNA Splicing - Major Pathway.
DR Reactome; R-BTA-72165; mRNA Splicing - Minor Pathway.
DR Proteomes; UP000009136; Chromosome 19.
DR Bgee; ENSBTAG00000013526; Expressed in choroid plexus and 108 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1MII4; baseline and differential.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; IBA:GO_Central.
DR GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0030623; F:U5 snRNA binding; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR CDD; cd04098; eEF2_C_snRNP; 1.
DR CDD; cd04090; EF2_II_snRNP; 1.
DR CDD; cd01683; EF2_IV_snRNP; 1.
DR CDD; cd16264; snRNP_III; 1.
DR CDD; cd04167; Snu114p; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.70.240; -; 1.
DR Gene3D; 3.30.70.870; Elongation Factor G (Translational Gtpase), domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 3.90.1430.10; Yeast translation eEF2 (G' domain); 1.
DR InterPro; IPR041095; EFG_II.
DR InterPro; IPR035647; EFG_III/V.
DR InterPro; IPR000640; EFG_V-like.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR031950; EFTUD2_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR044121; Snu114_GTP-bd.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR005517; Transl_elong_EFG/EF2_IV.
DR InterPro; IPR035655; U5-116kDa_C.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR42908:SF6; 116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT; 1.
DR PANTHER; PTHR42908; TRANSLATION ELONGATION FACTOR-RELATED; 1.
DR Pfam; PF00679; EFG_C; 1.
DR Pfam; PF14492; EFG_III; 1.
DR Pfam; PF03764; EFG_IV; 1.
DR Pfam; PF16004; EFTUD2; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SMART; SM00838; EFG_C; 1.
DR SMART; SM00889; EFG_IV; 1.
DR SUPFAM; SSF54980; EF-G C-terminal domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Spliceosome {ECO:0000256|ARBA:ARBA00022728}.
FT DOMAIN 153..435
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 38..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..75
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 998 AA; 112631 MW; FDFC670CC6B2662E CRC64;
MVNHRPGWRP RFPHQHLTFL LLNFSTMDTD LYDEFGNYIG PELDSDEDDD ELGRETKDLD
EVDEDEDDDD VGDHDEDHPG MEVVLHEDKK YYPTAEEVYG PEVETIVQEE DTQPLTEPII
KPVKTKKFTL MEQTLPVTVY EMDFLADLMD NSELIRNVTL CGHLHHGKTC FVDCLIEQTH
PEIRKRYDQD LCYTDILFTE QERGVGIKST PVTVVLPDTK GKSYLFNIMD TPGHVNFSDE
VTAGLRISDG VVLFIDAAEG VMLNTERLIK HAVQERLAVT VCINKIDRLI LELKLPPTDA
YYKLRHIVDE VNGLISMYST DENLILSPLL GNVCFSSSQY SICFTLGSFA KIYADTFGDI
NYQEFAKRLW GDIYFNPKTR KFTKKAPTSS SQRSFVEFIL EPLYKILAQV VGDVDTSLPR
TLDELGIHLT KEELKLNIRP LLRLVCKKFF GEFTGFVDMC VQHIPSPKVG AKPKIEHTYT
GGVDSDLGEA MSDCDPDGPL MCHTTKMYST DDGVQFHAFG RVLSGTIHAG QPVKVLGENY
TLEDEEDSQI CTVGRLWISV ARYHIEVNRV PAGNWVLIEG VDQPIVKTAT ITEPRGNEEA
QIFRPLKFNT TSVIKIAVEP VNPSELPKML DGLRKVNKSY PSLTTKVEES GEHVILGTGE
LYLDCVMHDL RKMYSEIDIK VADPVVTFCE TVVETSSLKC FAETPNKKNK ITMIAEPLEK
GLAEDIENEV VQITWNRKKL GEFFQTKYDW DLLAARSIWA FGPDATGPNI LVDDTLPSEV
DKALLGSVKD SIVQGFQWGT REGPLCDELI RNVKFKILDA VVAQEPLHRG GGQIIPTARR
VVYSAFLMAT PRLMEPYYFV EVQAPADCVS AVYTVLARRR GHVTQDAPIP GSPLYTIKAF
IPAIDSFGFE TDLRTHTQGQ AFSLSVFHHW QIVPGDPLDK SIVIRPLEPQ PAPHLAREFM
IKTRRRKGLS EDVSISKFFD DPMLLELAKQ DVVLNYPM
//
