ID A0A3Q1MIP0_BOVIN Unreviewed; 2252 AA.
AC A0A3Q1MIP0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Laminin subunit alpha 1 {ECO:0000313|Ensembl:ENSBTAP00000071159.1};
GN Name=LAMA1 {ECO:0000313|Ensembl:ENSBTAP00000071159.1,
GN ECO:0000313|VGNC:VGNC:30769};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000071159.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000071159.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000071159.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000071159.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000071159.1};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Secreted, extracellular space, extracellular matrix, basement membrane
CC {ECO:0000256|ARBA:ARBA00004302}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR Ensembl; ENSBTAT00000082228.1; ENSBTAP00000071159.1; ENSBTAG00000018160.6.
DR VEuPathDB; HostDB:ENSBTAG00000018160; -.
DR VGNC; VGNC:30769; LAMA1.
DR GeneTree; ENSGT00940000157124; -.
DR Proteomes; UP000009136; Chromosome 24.
DR Bgee; ENSBTAG00000018160; Expressed in granulosa cell and 58 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1MIP0; baseline.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProt.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR CDD; cd00055; EGF_Lam; 14.
DR CDD; cd00110; LamG; 4.
DR Gene3D; 2.60.120.200; -; 4.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 15.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR010307; Laminin_dom_II.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR000034; Laminin_IV.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR10574:SF409; LAMININ SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00052; Laminin_B; 1.
DR Pfam; PF00053; Laminin_EGF; 17.
DR Pfam; PF00054; Laminin_G_1; 4.
DR Pfam; PF06009; Laminin_II; 1.
DR Pfam; PF00055; Laminin_N; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 12.
DR SMART; SM00180; EGF_Lam; 17.
DR SMART; SM00281; LamB; 1.
DR SMART; SM00282; LamG; 4.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 4.
DR SUPFAM; SSF57196; EGF/Laminin; 13.
DR PROSITE; PS01248; EGF_LAM_1; 6.
DR PROSITE; PS50027; EGF_LAM_2; 10.
DR PROSITE; PS50025; LAM_G_DOMAIN; 2.
DR PROSITE; PS51115; LAMININ_IVA; 1.
DR PROSITE; PS51117; LAMININ_NTER; 1.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 1..233
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 361..413
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 414..462
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 637..685
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 744..795
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 796..844
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 845..890
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 891..936
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 937..987
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1072..1256
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 1298..1346
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1404..1450
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1644..1947
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2072..2247
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DISULFID 361..373
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 389..398
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 433..442
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 655..664
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 768..777
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 780..794
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 796..808
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 798..815
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 817..826
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 864..873
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 909..918
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 937..949
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 939..956
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 958..967
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1317..1326
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1404..1416
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1406..1423
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1425..1434
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 2252 AA; 244839 MW; 27CF03DF185AA55D CRC64;
TNATCGEKGP ETYCKLVEHV PGANPKGKKP RACRVFCFPS TERHPISNAI DGTNNWWQSP
SIQNGREYHW VTITLDLRQV FQVAYVIIKA ANAPRPGNWI LERSVDGVKF SPWQYYAVSD
TECLTHYNIT PRRGPPTYRA DDEVICTSYY SRLVPLEHGE IHTSLINGRP SSDDLSPKLL
DFTSARYIRL RLQRIRTLNA DLMTLSHRDP KDLDPIVTRR YYYSIKDISV GGMCICYGHA
SSCPWDEGTK KFQCQCEHNT CGDRCNRCCP GYHQQPWRPG TVSSGNTCEE CNCHNKAKDC
YYDEDVANQR RSLNIAGQFR GGGVCIGCLQ NTMGVNCETC VDGYYRPHGV SPYEDHPCRP
CDCDPVGSLN SVCIKDDLHS DLHRGQCPCK EGYAGEKCDR CHFGYKGYPE CVSCDCNPAG
SVNEEPCSES CLCKENVEGS HCDRCKPGFY NLEEKNPQGC SECFCFGVSD VCESLSWPVS
QVKDMSGWLV TDLVSSNQIR SQEDALGGRH QISINNSAVE QRLTSQYYWA APEAYLGNKV
SVVTVSGAGI SSTFAKNFGW PFTYVLSCVT GPICVSVGRL DSVSLDVASP NVIDLSLATE
VEHCECPQGY AGISCESCLP GYYRVDGILF GGICQPCECH GHAAECDVHG VCFACQHNTT
GEHCERCLPG FYGLPSRGTP GDCQPCACPL STASNNFSPT CHLDDGDEVV CDQCAPGYMG
DWCERCADGY YGNPTVPGDS CVACNCSGNV DLLEPGSCDS VTGECLRCLG NTDGPHCERC
ADGFYGDAVT AKNCPCECHG QGSLSAVCHP ETGLCECKPH VTGQRCDQCL YGYYGLETGL
GCLPCNCSAG SLSDDCTPEG HCLCVPGVAG EKCDRCARGF YSYQDGGCTP CDCAHTQNTC
DPETGECVCP PHTRGAACEE CADGHWGHDL ELGCQACNCS SVGAASQRCD VVTGHCRCKP
AFGGRTCEQC SPGYKGFPDC MACDCDPRGT LADTCDQEQG LCSCAQETGA CSCKVLENVA
GPQCGECRAG TFALDKADPR GCTPCFCFGL SQLCSEAQGY VRTPVTLGSD QPLLRVVSQS
NLKGTTEGVY YQAPDVLLDA VTVRQQVHAE PFYWRLPGQF QGDQLLAYGG TLRYSVAFYA
SDGIGTSNLE PQVLVKGGRT RKQVIYVDAP APENGVRQEQ EVGMTESFWK YFNSVSEEPV
TRSDFMSVLS NIEYILIKAS YGQGLQQSRI SNISMEVGRK AEELHAGRVV ALLLEKCVCP
PGTAGLSCQD CAPGYHRGKL PEGDGRRPRP LLAPCVPCNC NNHSDTCDPE TGKCLNCGHN
TTGDHCDTCA PGYYGKVTGS ASDCSPCTCP HSLPASYSPT CILEGDHDFR CDACFVGYEG
QYCERCSSGY YGNPRMPGST CQRCDCSPHG SVHSDCDRGS GQCICRPGAT GLRCGDCEPR
HILVESDCVS CDDDCVGVLL NDLAHVGDAI LSVNLTSTIP LPYGVLSDLE NRTKSLRVGT
ANTAMDRSVC HRKLKSCGLG NVRHVSLNAT SAAHVHSNIR SLIEESERLA TDALGTVKEA
SAVRKALGFP CVPALSLRCG QVSLSCDAQA ERQWLKKVKD VETQANLLLD RLKPLKMLEE
NLSRNLSEIK LLISQARKQA ASIKVAVSAD RDCIRAYQPQ ISSTNYNSLT LNVKTSEPDN
LLFYLGSSTS ADFLAVEMRR GKVAFLWDLG SGSTRLEFPD FPIDDNKWHG IYVTRFGNIG
SLSVKEMSAA QKPPPRTSKS PGTAKVLDVN NSTMMFVGGL GGQIKKSPAV KVTHFKGCMG
EVTPQMLMCT VTWSREKKDF LSIDLVDGRV RVTVDLGSGP LALITDRRYN NGTWYKIAFQ
RNKKQGKCED RRTKCPSGNE NLSKVSSLCF FFSFLIIRSK LCCCCCPVLP YRKGVSSKSY
VGCIKNLEIS RSTFDLLRNS YGVRKGCILE VGKPSPPSRL SVQLRIRTFA SSGLVFYMAH
QNQVDHAALQ LHAGRLHFTF DLGKGRTKVS HPALLSDGQW HTVGSREGGV TRAKLCSTAP
RVHSVSQYQQ LHMDIPMSAF AVTRCYAVAQ EGTFFEGSGY AALGIEGYRV RSDVNITLEF
RTSSENGVLL GISSAKVDAI GLEIVDGKLL FHVNNGAGRI TATYEPKTPS RLCDGRWHTL
QANKSKHRVV LTVDGNVVRA ESPHTQSTSA DTSDPIYVGG YPGQNCLSSR TSFRGCVRRL
TLTKGPQVQS FDFSTAFDLQ GVFPHSCPGT ES
//