ID A0A3Q1MJM4_BOVIN Unreviewed; 90 AA.
AC A0A3Q1MJM4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Peptide YY {ECO:0000256|ARBA:ARBA00040208};
DE AltName: Full=Peptide tyrosine tyrosine {ECO:0000256|ARBA:ARBA00042666};
GN Name=PYY {ECO:0000313|Ensembl:ENSBTAP00000069375.1};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000069375.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000069375.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000069375.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000069375.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000069375.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: This gut peptide inhibits exocrine pancreatic secretion, has
CC a vasoconstrictory action and inhibitis jejunal and colonic mobility.
CC {ECO:0000256|ARBA:ARBA00037595}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the NPY family. {ECO:0000256|ARBA:ARBA00010022,
CC ECO:0000256|RuleBase:RU000656}.
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DR AlphaFoldDB; A0A3Q1MJM4; -.
DR Ensembl; ENSBTAT00000069195.1; ENSBTAP00000069375.1; ENSBTAG00000046022.2.
DR VEuPathDB; HostDB:ENSBTAG00000046022; -.
DR GeneTree; ENSGT00940000160643; -.
DR OMA; SEGADQW; -.
DR Proteomes; UP000009136; Chromosome 19.
DR Bgee; ENSBTAG00000046022; Expressed in ascending colon and 78 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1MJM4; baseline.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR CDD; cd00126; PAH; 1.
DR Gene3D; 6.10.250.900; -; 1.
DR InterPro; IPR001955; Pancreatic_hormone-like.
DR InterPro; IPR020392; Pancreatic_hormone-like_CS.
DR PANTHER; PTHR10533; NEUROPEPTIDE Y/PANCREATIC HORMONE/PEPTIDE YY; 1.
DR PANTHER; PTHR10533:SF14; PEPTIDE YY-RELATED; 1.
DR Pfam; PF00159; Hormone_3; 1.
DR PRINTS; PR00278; PANCHORMONE.
DR SMART; SM00309; PAH; 1.
DR PROSITE; PS00265; PANCREATIC_HORMONE_1; 1.
DR PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
PE 3: Inferred from homology;
KW Amidation {ECO:0000256|ARBA:ARBA00022815};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..90
FT /note="Peptide YY"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018560678"
SQ SEQUENCE 90 AA; 10275 MW; 3092C7F7A7DBFFD3 CRC64;
MMSGRRSWPA MATVLLTLLV CLGELVDAYP AKPQAPGEHA SPDELNRYYT SLRHYLNLVT
RQRFGKRDFS EALLSILLFP DREDPPVKSR
//
