ID A0A3Q1MKM9_BOVIN Unreviewed; 861 AA.
AC A0A3Q1MKM9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Potassium channel tetramerization domain containing 1 {ECO:0000313|Ensembl:ENSBTAP00000071458.1};
GN Name=KCTD1 {ECO:0000313|Ensembl:ENSBTAP00000071458.1};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000071458.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000071458.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000071458.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000071458.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000071458.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_005224133.1; XM_005224076.2.
DR AlphaFoldDB; A0A3Q1MKM9; -.
DR SMR; A0A3Q1MKM9; -.
DR Ensembl; ENSBTAT00000068462.1; ENSBTAP00000071458.1; ENSBTAG00000050380.1.
DR CTD; 284252; -.
DR VEuPathDB; HostDB:ENSBTAG00000050380; -.
DR GeneTree; ENSGT00940000156453; -.
DR InParanoid; A0A3Q1MKM9; -.
DR OMA; DWEEPLE; -.
DR OrthoDB; 2912088at2759; -.
DR Reactome; R-BTA-8866904; Negative regulation of activity of TFAP2 (AP-2) family transcription factors.
DR Proteomes; UP000009136; Chromosome 24.
DR Bgee; ENSBTAG00000050380; Expressed in rumen epithelium and 102 other cell types or tissues.
DR GO; GO:0034451; C:centriolar satellite; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0045171; C:intercellular bridge; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IBA:GO_Central.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR CDD; cd18387; BTB_POZ_KCTD1; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR048599; BTB_POZ_KCTD1.
DR InterPro; IPR021893; DUF3504.
DR InterPro; IPR048595; KCTD1-15-like_C.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR PANTHER; PTHR21446:SF3; BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD1 ISOFORM X1; 1.
DR PANTHER; PTHR21446; DUF3504 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF02214; BTB_2; 1.
DR Pfam; PF12012; DUF3504; 1.
DR Pfam; PF20871; KCTD1-15_CTD; 1.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 634..736
FT /note="BTB"
FT /evidence="ECO:0000259|SMART:SM00225"
FT REGION 1..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 124..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 350..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 483..528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 575..630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..109
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 579..630
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 861 AA; 95885 MW; B0672230BED29DBB CRC64;
MARMPGSGDC NTSAGGSAAA AAAENNGERG EGERGVGGRG RRHGRPHYCS AGEEEEEDEE
EDEIQEVQIT GDEEEEEDGG GGLEEDEEEE EEMGLDWDEP LEPEDSAGEE LEPEPVHRIN
MDQSGALEPE APPRLLAPRA RGGPPGAGAE LDPDVLQRPE RARLSENTRL ATRYAVRIFR
EYLSEKAQSP DFETMDKGAL CRVLRSFYAE ARSKSGQLYS KSSLISIRSS LNRYLNEPPY
CRTLDLTKDP ELRSANLTLA AVIRKLEEQG AGPVVQKQAI TRADLRKLYT SSVFSTNTPF
GLLNKVWFET CMYFCTRGRE NQRELEEDSF GLAMDEDGRK FVYFKSLGPY HKSRSSSWSK
KRAESSDEEN LPRMYETGTE FCPYASFVKY LSKRNPLCKA FFQRPRDHCS EGDVTWYENK
AIGKNLLGTR MQMLSKAAKL SKTYTNHCIG AVSIATLNSI AGIGTKLGSP APQGCYAEAL
NGAARHHSHQ PPTHPSHHHR PQPPSLGNTY ILPRDSQVGP DVKSEAAPKR ALYESVFGSG
EMCGPSSPKR LCIRPSEPVD AVVVVSVKHD PLPLLPEANG HRSSNSPTIV SPAIISPTQD
SRPNMSRPLI TRSPASPLNN QGIPTPAQLT KSNAPVHIDV GGHMYTSSLA TLTKYPESRI
GRLFDGTEPI VLDSLKQHYF IDRDGQMFRY ILNFLRTSKL LIPDDFKDYT LLYEEAKYFQ
LQPMLLEMER WKQDRESGRF SRPCECLVVR VAPDLGERIT LSGDKSLIEE VFPEIGDVMC
NSVNAGWNHD STHVIRFPLN GYCHLNSVQV LERLQQRGFE VVGSCGGGVD SSQFSEYVLR
RELRRTPRGP SVIRIKQEPL D
//
