ID A0A3Q1MLS9_BOVIN Unreviewed; 1391 AA.
AC A0A3Q1MLS9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=L1 cell adhesion molecule {ECO:0000313|Ensembl:ENSBTAP00000072651.1};
GN Name=L1CAM {ECO:0000313|Ensembl:ENSBTAP00000072651.1,
GN ECO:0000313|VGNC:VGNC:30760};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000072651.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000072651.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000072651.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000072651.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000072651.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily.
CC L1/neurofascin/NgCAM family. {ECO:0000256|ARBA:ARBA00008588}.
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DR RefSeq; XP_015317002.1; XM_015461516.1.
DR Ensembl; ENSBTAT00000071285.1; ENSBTAP00000072651.1; ENSBTAG00000013462.6.
DR GeneID; 516017; -.
DR CTD; 3897; -.
DR VEuPathDB; HostDB:ENSBTAG00000013462; -.
DR VGNC; VGNC:30760; L1CAM.
DR GeneTree; ENSGT00940000157506; -.
DR Proteomes; UP000009136; Chromosome X.
DR Bgee; ENSBTAG00000013462; Expressed in retina and 92 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1MLS9; baseline.
DR GO; GO:0030424; C:axon; IEA:Ensembl.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR GO; GO:0007411; P:axon guidance; IEA:Ensembl.
DR GO; GO:0016477; P:cell migration; IEA:Ensembl.
DR GO; GO:0007160; P:cell-matrix adhesion; IEA:Ensembl.
DR GO; GO:0050808; P:synapse organization; IEA:Ensembl.
DR CDD; cd00063; FN3; 4.
DR CDD; cd05876; Ig3_L1-CAM; 1.
DR CDD; cd05867; Ig4_L1-CAM_like; 1.
DR CDD; cd05845; IgI_2_L1-CAM_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 10.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR026966; Neurofascin/L1/NrCAM_C.
DR PANTHER; PTHR44170:SF44; L1 CELL ADHESION MOLECULE; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF13882; Bravo_FIGEY; 1.
DR Pfam; PF00041; fn3; 4.
DR Pfam; PF07679; I-set; 3.
DR Pfam; PF13927; Ig_3; 2.
DR SMART; SM00060; FN3; 4.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 5.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS50835; IG_LIKE; 6.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1259..1281
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 172..267
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 277..364
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 378..466
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 471..558
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 563..651
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 656..745
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 752..850
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 855..948
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 951..1054
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1058..1153
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 834..864
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1291..1341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1364..1391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1291..1316
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1375..1391
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1391 AA; 154615 MW; 470CF80B3AA73975 CRC64;
MFPRRPCMPC ASCKLQSFLL PGSCGTWWRG EGGRLCSVSS RWVSSLAFHL SLVVHPSLWS
SSLPVRGLPS LVLLPLASPV SLFFLSHALS FCLASSLSSG FFLCDFWCHL LSVLVPSTFA
QLLWAQLAPP RPTTQWPCGL SGSRPGFCPH GTRVRAEVLT MSVPPPAPVM EPPIITEQSP
RRVVVFPTDD VSLKCEASGK PEVQFRWTRD GILFKPREEL GMIVNQVPHS GSFSITGNSS
NFAQSFQGTY RCFASNKLGT AMSHEIQLMA EGTPKWPKET VKPVEVEEGE SVILPCHPPP
SAEPLRIYWM NSKILHIKQD ERVTMGQNGN LYFANVLTSD NHSDYICHAH FPGTRTIIQK
EPIDLRVKAT NSMMDRKPHL LFPTNSSSHL VALQGQPLIL ECIAEGFPTP TIKWLRPSGP
MPADRVTYQN HNKTLQLLNV GEEDDGEYRC LAENSLGSDR HAYYVTVEAA PYWLHKPQSH
LYGPGETARL DCQVQGRPQP EVTWRINGIP VEELGKDQKY RIHHGALVLS NLQPSDTMVT
QCEARNRHGL LLANAYIYVV ELPAKILTPD NETYMAVQGS TAYLLCKAFG APVPSVQWLD
REGKTVLQDE RFFPYTNGTL GIRDLQTNDT GHYFCQAAND QSNVTIVANL QVKDATRIMQ
GPRSAIEKRG SRVMFTCQAS FDPSLQHSTT WRRDALDLQE LGDSDKYFIE DERLVIHSLD
YSDQGNYSCV ASTKLDVVES RAELLVVGSP GPVPQLELSD HHLLKQSQVR LSWSPADDHN
APIEKYDIEF EDKEMAPEKW YSLGKVPGNQ TSTTLKLSPY VHYTFRVTAI NKYGPGEPSP
DSETVVTPEA APEKNPVDVK GEGNETNNMV ITWKPLRWMD WNAPQVQYRV QWRPQKMQGA
WQEQIVSDPF LVVSNTSTFV PYEIKVQTVN SQGKGPEPQI TIGYSGEDYP QASPLLEPVK
ALNSSTVLVR WQSVDPAQVK GHLRGYNVTY WWEGSQRKHN KRHVHKGHVV VPANATSTIL
GGLRPYSSYW VEVQAFNGRG LGPASGMTFN TPEGVPGHPE ALHLECQSDT SLLLHWQPPL
SHNGVLTGYV LSYQPLNDGS KEQLSFDLPD PELRTHNLTN LSPRLRYRFQ LQATTREGPG
EAIVREGGTM ALSGMPDFGN ISAMAGENYS VVSWVPKEGQ CNFGFQIWFK ALGDEKLVAR
LPPQYVSYNQ SSYTQWDLQP DTDYEIQLLK EQVLLHQMAV KTNGTGRVRL PPAGFATEGW
FIGFISAIVV LLLVLLILCF IKRSKGGKYS VKDKEDTQVD SEARPMKDET FGEYSDNEEK
AFGSSQPSLN GDIKPLGSDD SLADYGGSVD VQFNEDGSFI GQYSGKKEKE VAGGNDSSGA
TSPINPAGTL E
//
