ID A0A3Q1MMZ8_BOVIN Unreviewed; 1257 AA.
AC A0A3Q1MMZ8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Membrane associated guanylate kinase, WW and PDZ domain containing 1 {ECO:0000313|Ensembl:ENSBTAP00000073229.1};
GN Name=MAGI1 {ECO:0000313|Ensembl:ENSBTAP00000073229.1,
GN ECO:0000313|VGNC:VGNC:31147};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000073229.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000073229.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000073229.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000073229.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000073229.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3Q1MMZ8; -.
DR Ensembl; ENSBTAT00000078616.1; ENSBTAP00000073229.1; ENSBTAG00000010581.6.
DR VEuPathDB; HostDB:ENSBTAG00000010581; -.
DR VGNC; VGNC:31147; MAGI1.
DR GeneTree; ENSGT00940000155820; -.
DR Proteomes; UP000009136; Chromosome 22.
DR Bgee; ENSBTAG00000010581; Expressed in intramuscular adipose tissue and 105 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1MMZ8; baseline.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 4.
DR CDD; cd00201; WW; 2.
DR Gene3D; 2.20.70.10; -; 2.
DR Gene3D; 2.30.42.10; -; 4.
DR Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR10316; MEMBRANE ASSOCIATED GUANYLATE KINASE-RELATED; 1.
DR PANTHER; PTHR10316:SF12; MEMBRANE-ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF16663; MAGI_u1; 1.
DR Pfam; PF16666; MAGI_u5; 1.
DR Pfam; PF00595; PDZ; 4.
DR Pfam; PF00397; WW; 2.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 4.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 4.
DR SUPFAM; SSF51045; WW domain; 2.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 4.
DR PROSITE; PS01159; WW_DOMAIN_1; 2.
DR PROSITE; PS50020; WW_DOMAIN_2; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 59..135
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT DOMAIN 246..279
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 293..326
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 367..436
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 538..616
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 708..790
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 918..1000
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 182..213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 329..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 481..518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 615..687
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 799..854
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 999..1257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 335..353
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 482..501
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 632..661
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 802..849
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1048..1251
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1257 AA; 140116 MW; 2C6DE4A029579E04 CRC64;
GQRSLVGYSP WGHKESDTTE RLHFHFHLAV YRSSCCFTVL LKPNIDFFHC GRYLNKDLRH
FLNQRFQKGS PDHELQQTIR DNLYRHAVPC TTRSPREGEV PGVDYNFLTV KEFLDLEQSG
TLLEVGTYEG NYYGTPKPPS QPVSGKVITT DALQNLHSGS KQSTPKRTKS YNDMQNAGIV
HAENEEEDDV PEMNSSFTAD SGDQEEHSLQ EAAHPPVNSS IIAAPITDPS QKFPQYLPLS
AEDNLGPLPE NWEMAYTENG EVYFIDHNTK TTSWLDPRCL NKQQKPLEEC EDDELPAGWE
KIEDPVYGIY YVDHINRKTQ YENPVLEAKR KKQLEQQQQQ QQQQQQQPEG KPFFTRNPSE
LKGKFIHTKL RKSSRGFGFT VVGGDEPDEF LQIKSLVLDG PAALDGKMET GDVIVSVNDT
CVLGHTHAQV VKIFQSIPIG ASVDLELCRG YPLPFDPDDP NTSLVTSVAI LDKEPIIVNG
QETYDSPASH SSKTGKVSSM KDARPSSPAD VASNGSHGYP TDTVSLASSI ATQPELITVH
IVKGPMGFGF TIADSPGGGG QRVKQIVDSP RCRGLKEGDL IVEVNKKNVQ ALTHNQVVDM
LIECPKGSEV TLLVQRGGLP VPKKSPKSQP LERKDSQNSS QHSVASHRSL HTASPSHSTQ
VLPELPPAEA PAPDQTDNSG QKKPDPFKIW AQSRSMYENR LPDYQEQDIF LWRKETGFGF
RILGGNEPGE PIYIGHIVPL GAADTDGRLR SGDELICVDG TPVIGKSHQL VVQLMQQAAK
QGHVNLTVRR KVVFAAPKTE NEVPSPASSH HSSNQPASLT EEKRTPQGSQ NSLNTVSSGS
GSTSGIGSGG GGGSGVVSTV VQPYDVEIRR GENEGFGFVI VSSVSRPEAG TTFGELIDIN
KQLETTKKGI QIEQDFYTVE LERGAKGFGF SLRGGREYNM DLYVLRLAED GPAERCGKMK
VGDEILEING ETTKNMKHSR AIELIKNGGR RVRLFLKRGD GSVPEYDPGS DGNGPPTGPQ
GVPEMRAGPP DRRQHPSLES SYPPDLHKSS PHGEKRAHVR DPKGSREYSR QPNEHHTWNG
TSRKPDSGAC RPKDRAPEGR RDAQPERMVT NGPKRRSPEK RREGTRSADN TLERREKQEK
RKEVSPERRR ERSPTRRRDG SPGRRRRSLE RLLDQRRSPE RKRGSSPERR AKSTDRRRTK
SPERRRERSL EKRNKEDRGS HRERDETSLR QDTGRSSRHP PEQRRRPYKE CSTDLSI
//
