ID A0A3Q1MNZ3_BOVIN Unreviewed; 421 AA.
AC A0A3Q1MNZ3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=tRNA (guanine(10)-N2)-methyltransferase homolog {ECO:0000256|ARBA:ARBA00013960};
DE AltName: Full=tRNA guanosine-2'-O-methyltransferase TRM11 homolog {ECO:0000256|ARBA:ARBA00032604};
GN Name=TRMT11 {ECO:0000313|Ensembl:ENSBTAP00000073609.1,
GN ECO:0000313|VGNC:VGNC:36368};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000073609.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000073609.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000073609.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000073609.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000073609.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Catalytic subunit of an S-adenosyl-L-methionine-dependent
CC tRNA methyltransferase complex that mediates the methylation of the
CC guanosine nucleotide at position 10 (m2G10) in tRNAs.
CC {ECO:0000256|ARBA:ARBA00002425}.
CC -!- SUBUNIT: Interacts with TRMT112. {ECO:0000256|ARBA:ARBA00033754}.
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DR RefSeq; XP_010806693.1; XM_010808391.2.
DR AlphaFoldDB; A0A3Q1MNZ3; -.
DR Ensembl; ENSBTAT00000078273.1; ENSBTAP00000073609.1; ENSBTAG00000001957.5.
DR GeneID; 514867; -.
DR CTD; 60487; -.
DR VEuPathDB; HostDB:ENSBTAG00000001957; -.
DR VGNC; VGNC:36368; TRMT11.
DR GeneTree; ENSGT00390000018131; -.
DR Proteomes; UP000009136; Chromosome 9.
DR Bgee; ENSBTAG00000001957; Expressed in oocyte and 107 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1MNZ3; baseline and differential.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0009451; P:RNA modification; IEA:UniProt.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR000241; RlmKL-like_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016691; tRNA_mtfrase_TRM11.
DR PANTHER; PTHR13370; RNA METHYLASE-RELATED; 1.
DR PANTHER; PTHR13370:SF3; TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG; 1.
DR Pfam; PF01170; UPF0020; 1.
DR PIRSF; PIRSF017259; tRNA_mtfrase_TRM11; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
DR PROSITE; PS51627; SAM_MT_TRM11; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022555};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555}.
FT DOMAIN 190..320
FT /note="UPF0020"
FT /evidence="ECO:0000259|Pfam:PF01170"
SQ SEQUENCE 421 AA; 48389 MW; 3C8963E8B09162F1 CRC64;
MAPPGILNRY LLLMAQEHLE FRLPEIKSLL SLFGGQFISS QETYGKSPFW ILSIPSEDIA
RNLMKRTVCA KSIFELWGHG KCPEELYSSL KNYPVEKMVP FLHSDSTYKI KIHTFNKTLT
QEEKVKRIDA LEFLPFEGKV NLKKPQHVFS ILEDYGLDPN HIPENPHNIY FGRWIADGQR
ELIESYSVKK RHFIGNTSMD AGLSFIMANH GKVKKNDIVF DPFVGTGGLL IASAHFGAYV
YGTDIDYNTV HGLGKASRKN QKWRGPDENI RANLRQYGLE KYYLDVLVSD ASKPSWRKGT
YFDAIITDPP YGIRESTRRT GSQKEIPKGI EKCPESHVPV SLSYHLSDMF FDLLNFSAET
LVLGGRLVYW LPVYTPEYTE EMVPWHPCLK LISNCEQKLS SHTSRRLITM EKVKEFEDEM
M
//
