ID A0A3Q1MQ27_BOVIN Unreviewed; 432 AA.
AC A0A3Q1MQ27;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Carcinoembryonic antigen related cell adhesion molecule 1 {ECO:0000313|Ensembl:ENSBTAP00000073656.1};
GN Name=CEACAM1 {ECO:0000313|Ensembl:ENSBTAP00000073656.1};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000073656.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000073656.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000073656.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000073656.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000073656.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. CEA family.
CC {ECO:0000256|ARBA:ARBA00038222}.
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DR AlphaFoldDB; A0A3Q1MQ27; -.
DR SMR; A0A3Q1MQ27; -.
DR STRING; 9913.ENSBTAP00000073656; -.
DR PaxDb; 9913-ENSBTAP00000009007; -.
DR Ensembl; ENSBTAT00000069303.1; ENSBTAP00000073656.1; ENSBTAG00000005615.6.
DR VEuPathDB; HostDB:ENSBTAG00000005615; -.
DR GeneTree; ENSGT01100000263479; -.
DR InParanoid; A0A3Q1MQ27; -.
DR OMA; GDETEWT; -.
DR Reactome; R-BTA-1566977; Fibronectin matrix formation.
DR Reactome; R-BTA-163125; Post-translational modification: synthesis of GPI-anchored proteins.
DR Reactome; R-BTA-202733; Cell surface interactions at the vascular wall.
DR Reactome; R-BTA-6798695; Neutrophil degranulation.
DR Proteomes; UP000009136; Chromosome 18.
DR Bgee; ENSBTAG00000005615; Expressed in mesenteric lymph node and 104 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1MQ27; baseline and differential.
DR GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:1990782; F:protein tyrosine kinase binding; IBA:GO_Central.
DR GO; GO:0002682; P:regulation of immune system process; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR CDD; cd05740; IgI_hCEACAM_2_4_6_like; 1.
DR CDD; cd05774; IgV_CEACAM_D1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR44427:SF1; CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 1; 1.
DR PANTHER; PTHR44427; CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 19; 1.
DR Pfam; PF13927; Ig_3; 2.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..34
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 35..432
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018525413"
FT TRANSMEM 338..365
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 145..232
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 240..325
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 373..432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..394
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 399..426
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 432 AA; 47544 MW; 3FB2D28BCC32B75C CRC64;
MGTPSGPSRR RCIPWNRLLL AVSLLTFWTP PTTAQLTIET VPPLAAEGSD VLLLAHNVTK
NPLGYAWYRG ERVDNTQLIA SYRVDTNATT KGPAHSGRET LYPNGTLLIQ SVTQKDTGSY
MLLVTKDDLQ TERQTGHLHI LPMLPRPVIT SNNSNPWEHQ DTVVLTCGPE TQNTSYMWWI
NNQSLPNSTR LELSEDKRTL TVFNVTRNDT GPYVCEAWNP VSVSRSDPFT LNVLYPVAQP
SLQASNTTVI EHEGPVVLTC LTDETGISIR WFFKGRSLLL AQRMTLSSDN STLTIDPVSR
QDAGDYQCEV SNRGNSSRSD PLSLHVKYKL TPESSSDLSA GAIVGIVIGA MAGVALIGAL
VYFVASDQRD LTEHKSSDHN HSQGHSDSSP EKVDEVEYSS LNFNAQELKN KATSASPSPT
NTETIYSEVK KQ
//
