ID A0A3Q1MQP1_BOVIN Unreviewed; 847 AA.
AC A0A3Q1MQP1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Transcription factor E2F7 {ECO:0000256|ARBA:ARBA00039675};
GN Name=E2F7 {ECO:0000313|Ensembl:ENSBTAP00000072090.1,
GN ECO:0000313|VGNC:VGNC:28291};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000072090.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000072090.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000072090.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000072090.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000072090.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU003796}.
CC -!- SIMILARITY: Belongs to the E2F/DP family.
CC {ECO:0000256|ARBA:ARBA00010940, ECO:0000256|RuleBase:RU003796}.
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DR RefSeq; XP_010803050.1; XM_010804748.2.
DR RefSeq; XP_010825854.1; XM_010827552.2.
DR AlphaFoldDB; A0A3Q1MQP1; -.
DR Ensembl; ENSBTAT00000074071.1; ENSBTAP00000072090.1; ENSBTAG00000016931.4.
DR GeneID; 526129; -.
DR CTD; 144455; -.
DR VEuPathDB; HostDB:ENSBTAG00000016931; -.
DR VGNC; VGNC:28291; E2F7.
DR GeneTree; ENSGT00940000157713; -.
DR Proteomes; UP000009136; Chromosome 5.
DR Bgee; ENSBTAG00000016931; Expressed in oocyte and 53 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1MQP1; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR015633; E2F.
DR InterPro; IPR003316; E2F_WHTH_DNA-bd_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12081; TRANSCRIPTION FACTOR E2F; 1.
DR PANTHER; PTHR12081:SF25; TRANSCRIPTION FACTOR E2F7; 1.
DR Pfam; PF02319; E2F_TDP; 2.
DR SMART; SM01372; E2F_TDP; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003796};
KW Nucleus {ECO:0000256|RuleBase:RU003796};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU003796};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU003796}.
FT DOMAIN 141..210
FT /note="E2F/DP family winged-helix DNA-binding"
FT /evidence="ECO:0000259|SMART:SM01372"
FT DOMAIN 281..366
FT /note="E2F/DP family winged-helix DNA-binding"
FT /evidence="ECO:0000259|SMART:SM01372"
FT REGION 239..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 501..642
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 809..847
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 239..260
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 501..515
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 530..560
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 588..625
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 832..847
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 847 AA; 91945 MW; A64A886EB07993F3 CRC64;
MEVNCLTLKD LISRPPRLDF AIEDGENAQK ENIFVDLSRM APKTPIKNEP IDLSKQKIFT
PERNPITPVK LVDRQQVEPW TPTANLKILI SAASPDIRDR EKKKELFRPI ENKDDVFTDS
LQLDAVDDSA VDEFEKQRPS RKQKSLGLLC QKFLARYPSY PLSTEKTTIS LDEVAVSLGV
ERRRIYDIVN VLESLHLVSR VAKNQYSWHG RHSLPKTLRN LQRLGEKQKY EEQMAHLQQK
ELNPIDHKSG ERRRDGCPDS QDPQLLDFPE PDCPSSSANS RKDKSLKIMS QKFVMLFLVS
KTKIVTLDVA AKILIEESQD IPDHSKFKTK VRRLYDIANV LTSLMLIKKV HVTEDRGRKP
AFKWIGPVDF SSTGVYSLEI GSLAAVSRQK MEDNSETVAF ASQNMMPLPS SLDPAAPLPS
PSVDSEYRVS PLCHQALSAA QTDLKALPAQ NGLNGQGGVS LASMALDVEH QPQPLAAAQP
LLYVPPAPLF MLCGGLQEGL SPGSGSGSGS VGGGSEVTAA EQPPMPSGQK RLSKERRLQE
EEEEPATKRQ CRDHEDGPLS LVMPKKPSDS ADIASPKTSE NRASAPHEDT HMNGQLSAAK
AVSGKATTNG FVSSEWGNPC SNTEIEKPSE ENESTKGPSP LQYLYVQPPA GLNGLSVLLP
SSQSPHAVGL PVGPLPSLSI QYMVLPSPAL SGFPVLCSPT MPGPVSSAPS PLPNVGPVNF
GLPGLGSTAH LLIGPAAMVN PKSSTLPSTD PQLQGPCSLH LSPVMSRSHG SVQPGSPAYG
SLPAATVKLQ QSPVPVTPKS IRCTHQETFF KTPGSLGDPV LRRKERNQSR SSSSAQRRLE
ISSGGTD
//
