ID   A0A3Q1MUN2_BOVIN        Unreviewed;       747 AA.
AC   A0A3Q1MUN2;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Ras GTPase-activating protein 3 {ECO:0008006|Google:ProtNLM};
GN   Name=LOC112449111 {ECO:0000313|Ensembl:ENSBTAP00000058609.1};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000058609.1, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000058609.1, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000058609.1,
RC   ECO:0000313|Proteomes:UP000009136};
RA   Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA   Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA   Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT   "ARS-UCD1.2.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000058609.1}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000058609.1};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3Q1MUN2; -.
DR   SMR; A0A3Q1MUN2; -.
DR   STRING; 9913.ENSBTAP00000058609; -.
DR   Ensembl; ENSBTAT00000078849.1; ENSBTAP00000058609.1; ENSBTAG00000053845.1.
DR   VEuPathDB; HostDB:ENSBTAG00000053845; -.
DR   GeneTree; ENSGT00940000157953; -.
DR   InParanoid; A0A3Q1MUN2; -.
DR   OMA; FLHYSKI; -.
DR   Proteomes; UP000009136; Chromosome 12.
DR   Bgee; ENSBTAG00000053845; Expressed in blood and 100 other cell types or tissues.
DR   ExpressionAtlas; A0A3Q1MUN2; baseline.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   CDD; cd08401; C2A_RasA2_RasA3; 1.
DR   CDD; cd04010; C2B_RasA3; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 2.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR039360; Ras_GTPase.
DR   InterPro; IPR023152; RasGAP_CS.
DR   InterPro; IPR001936; RasGAP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   PANTHER; PTHR10194:SF53; RAS GTPASE-ACTIVATING PROTEIN 3; 1.
DR   PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR   Pfam; PF00168; C2; 2.
DR   Pfam; PF00616; RasGAP; 2.
DR   SMART; SM00239; C2; 2.
DR   SMART; SM00323; RasGAP; 1.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   PROSITE; PS50004; C2; 2.
DR   PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR   PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE   4: Predicted;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT   DOMAIN          1..110
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          121..261
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          349..522
FT                   /note="Ras-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50018"
FT   REGION          637..673
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   747 AA;  82949 MW;  4EE731ACC64BFCDE CRC64;
     LSLQDEGLGL LQLVTCGEAK NLPTYPGPNK MRDCYCTVNL DQEEVFRTKV VEKSLCPFYG
     EDFYCEIPRS FRHLSFYIFD RDVFRRDSII GKVAIQKEDL QKYHNRDTWF QLQHVDADSE
     VQGKVHLELR LSEVITDSGV VCHKLATRIL ECQGLPIVNG QCDPYATVTL AGPCRSEAKK
     TKVKKKTNNP QFDEVFYFEV TRPCSYSRKS HFDFEDEDVD KLEIRVDLWN ASNLKFGDEF
     LGELRVPLKV LRQSSPHEAW YFLQPRDNGS KSLKPGDLGS LRLNVVYTED HVFSSDYYSP
     LRDLLLKSAD VEPVSASAAH ILGEVCREKQ EAAIPAGAAL PALRPGGAFI SAIASAEVRR
     TQDPNTIFRG NSLTSKCIDE TMKLAGMQYL HVTLKPTIEE ICQSHKSCEI DPVRLKDGES
     LESNMENLRQ FVDRVFSVIT KSGVSCPTVM CDIFFSLREA AAKRFQDDLD VRYTAVSSFI
     FLRFFAPAIL SPNLFQLTPH HTDPQTSRTL TLVSKTIQTL GSLSKSKSVI FKESYMAAFY
     EFFNEQKYAD AVKNFLDLIS SSGRRDPKSV QQPILLRGRG PARRARASRA AWALVCGSET
     PQGCSPVLCC PLRLRGEECP SVGREREETE RPRVVRGFCP VAPSPESKGP LPSISPPAEA
     SPAGAQSTGR SPEAAGFLLS LPPEHACGVG PTATLALGAP LVHVFRAGGG APCWSSGRPE
     LSATRNLRLT VDTSTGLNFS KVEAFIF
//