ID A0A3Q1MUV0_BOVIN Unreviewed; 1016 AA.
AC A0A3Q1MUV0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN Name=FBH1 {ECO:0000313|Ensembl:ENSBTAP00000074463.1,
GN ECO:0000313|VGNC:VGNC:28896};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000074463.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000074463.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000074463.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000074463.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000074463.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR AlphaFoldDB; A0A3Q1MUV0; -.
DR Ensembl; ENSBTAT00000082535.1; ENSBTAP00000074463.1; ENSBTAG00000004147.6.
DR VEuPathDB; HostDB:ENSBTAG00000004147; -.
DR VGNC; VGNC:28896; FBH1.
DR GeneTree; ENSGT00390000011669; -.
DR Proteomes; UP000009136; Chromosome 13.
DR Bgee; ENSBTAG00000004147; Expressed in granulosa cell and 107 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1MUV0; baseline and differential.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR CDD; cd22095; F-box_FBXO18; 1.
DR CDD; cd18786; SF1_C; 1.
DR Gene3D; 1.20.1280.50; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11070:SF30; F-BOX DNA HELICASE 1; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12937; F-box-like; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SMART; SM00256; FBOX; 1.
DR SUPFAM; SSF81383; F-box domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50181; FBOX; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 210..259
FT /note="F-box"
FT /evidence="ECO:0000259|PROSITE:PS50181"
FT REGION 96..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1016 AA; 114420 MW; 68E2295AC9509C1B CRC64;
MRRFKRKHLT AIECQHLARS HLAASQSFQR WTSRDPNHGL YPRPRTKRGA RGQGCLRYSL
DFFLAGQQPC TNDMAKSNSV GQDSSKDSED EMIFVAGSPC ALPPGGDGEA RLHSSGSALP
ARKRSRSLDD ERNPAPGTSP WDGVSKKTPW HHSSPSCTRP REARPEAEVG VGQLTVQPGE
PSQEVEDLGP DPVPDSHYGL LGTLPCQEPP SHICSLPSEV LRHIFAFLPV EDLYWNLSLV
CRLWREVISD PLFIPWKKLY HRYLMNEEQA VSKVDGILSS YGIEKESDLC VLNLIRYTAT
TKCSPSVDPG QALWSLRDHL LLPEAEACVR QHLPDLCAAP AGVNVWALVA AIVLLSSSVS
DIQQLLFCLR RPSSTVTVPD VTETLYCIAV LLYAMREKGI SISNRIHYNI FYCLYLQENS
CAQASGDKEE PSVWPGKKTT IQLTHEQQLI LSHKMEPLQV VKIMAFAGTG KTSTLVKYAE
KWSQSRFLYV TFNKSIAKQA ERVFPSNVIC KTFHSMAYGH IGRKYQLKKK LNLFKLTPFM
VNSVLTEGKG GFIRAKLVCK TLENFFASAD EELTIDHVPI WCKNTQGQRV MVEQSEKLNG
VLEASRLWDN MRKLGECREE AYHMTHDAIM NIVLSQPCGK IFVGDPHQQI YTFRGAVNAL
FTVPHTHVFY LTQSFRFGVE IAYVGATILD VCKRVRRKTL VGGNHQSGIR GDSKGQVALL
SRTNANVFDE AVRVTEGEVP ARIHLIGGIK SFGLDRIIDI WTLLQPEEER KKRNLIIKDK
FIRRWAHKEG FSGFKRYVTA AEDKELEAKI AVVEKYNIRI PELVARIERC HIEDLDFAEY
ILGTVHKAKG LEFDTVHVLD DFVKVPCARH NLAQLPHFRV ESFSEDEWNL LYVAVTRAKK
RLIMTRSLEN ILTLAGEYFL QAELTSNVLK TGVVRCCVGQ CSNAIPVDAA LTMRKLPITY
SNRKENKGGY LCHSCVEQRI GPLAFLTASP EQVRAMVRTV ENVVLPRHEA LLFLVF
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