ID A0A3Q1MWK6_BOVIN Unreviewed; 893 AA.
AC A0A3Q1MWK6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=dolichyl-phosphate-mannose--protein mannosyltransferase {ECO:0000256|ARBA:ARBA00012839};
DE EC=2.4.1.109 {ECO:0000256|ARBA:ARBA00012839};
GN Name=TMTC1 {ECO:0000313|Ensembl:ENSBTAP00000059884.1,
GN ECO:0000313|VGNC:VGNC:36146};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000059884.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000059884.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000059884.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000059884.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000059884.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC {ECO:0000256|ARBA:ARBA00004922}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004240}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMTC family.
CC {ECO:0000256|ARBA:ARBA00007882}.
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DR AlphaFoldDB; A0A3Q1MWK6; -.
DR Ensembl; ENSBTAT00000075592.1; ENSBTAP00000059884.1; ENSBTAG00000005370.6.
DR VEuPathDB; HostDB:ENSBTAG00000005370; -.
DR VGNC; VGNC:36146; TMTC1.
DR GeneTree; ENSGT00940000158027; -.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000009136; Chromosome 5.
DR Bgee; ENSBTAG00000005370; Expressed in intramuscular adipose tissue and 102 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1MWK6; baseline and differential.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004169; F:dolichyl-phosphate-mannose-protein mannosyltransferase activity; IEA:UniProtKB-EC.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 4.
DR InterPro; IPR013618; TMTC_DUF1736.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR013105; TPR_2.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR44809; -; 1.
DR PANTHER; PTHR44809:SF1; PROTEIN O-MANNOSYL-TRANSFERASE TMTC1; 1.
DR Pfam; PF08409; TMTC_DUF1736; 1.
DR Pfam; PF13424; TPR_12; 1.
DR Pfam; PF13432; TPR_16; 2.
DR Pfam; PF07719; TPR_2; 2.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00028; TPR; 9.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50005; TPR; 6.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 112..132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 138..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 203..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 332..354
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 374..393
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 413..432
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 444..462
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 491..511
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 349..421
FT /note="DUF1736"
FT /evidence="ECO:0000259|Pfam:PF08409"
FT REPEAT 540..573
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 605..638
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 673..706
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 740..773
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 800..833
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 834..867
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 245..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..267
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 893 AA; 100388 MW; 5A8D3125C38B0E96 CRC64;
MVVTSSARGG GGDRAPSRRR DCGLAPAGAA ALLAGASCLC YGRSLRGEFV HDDVWAIVNN
PDVRPGAPLL WGIFSNDFWG KGMAENTSHK SYRPLCVLTF KLNIFMTGMD PFYFHAVNVI
LHCLVTLVLM YTCDKTVFRN RGLAFVTALL FAVHPVHTEA VAGIVGRADV LACLLFLLAF
LSYNRSVDQC CVGESFPPTA SPFFLLLSLF LGTCAMLVKE TGITVFGVCL VYDLFSLSHN
HDKSSNGVIH QRSPQQPGSS PTAHPLRENG KQQRFPHKGA WGGCHAMPSE PKSSGFPVSP
GAVWSLMRYL TASSNRNFLL TMRPFLKRAT LVISYVIIVL YFRLWIMGGS MPLFSEQDNP
ASFSPYILTR FLTYSYLLAF NVWLLLAPVT LCYDWQVGSI PLVETIWDIR NGATILLAVV
MALLSLHCLA AFKRLEHREV LVGLLFLVFP FIPASNLFFR VGFVVAERVL YMPSMGYCIL
FVHGLSKLCT WLNRCGATTL SVSTVLLLLL FSWKTMKQNE IWLSRESLFR SGVQTLPHNA
KVHYNYANFL KDQGRNREAI YHYRTALKLY PRHASALNNL GTLTRDTTEA KMYYQRALQL
NPQHNRALFN LGNLLKSQEK KEEAITLLKD SIKYGPEFAD AYSSLASLLA EQERFKEAEE
IYLAGIKKCP DSSDLHNNYG VFLVDTGFPE KAVAHYQQAI KLSPSHHVAM VNLGRLYRSL
GDNSVAEEWY KRALQVARKT EILSPLGALY YNTGRYEEAL QTYREAVALQ PSQRELRLAL
ALDAIDKALK LKPKDPKVIS ELFFTKGNQL REQNLLDKAF ESYKAAVELN PDQAQAWMNM
GGIQHIKGNY VSARTYYERA LQLVPDSKLL QENLAKLDRL EKRLQEVREK NQT
//
