ID A0A3Q1MWL4_BOVIN Unreviewed; 591 AA.
AC A0A3Q1MWL4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Transporter {ECO:0000256|RuleBase:RU003732};
GN Name=SLC6A2 {ECO:0000313|Ensembl:ENSBTAP00000059899.1,
GN ECO:0000313|VGNC:VGNC:34920};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000059899.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000059899.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000059899.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000059899.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000059899.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC 2.A.22) family. {ECO:0000256|RuleBase:RU003732}.
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DR AlphaFoldDB; A0A3Q1MWL4; -.
DR Ensembl; ENSBTAT00000086297.1; ENSBTAP00000059899.1; ENSBTAG00000003353.6.
DR VEuPathDB; HostDB:ENSBTAG00000003353; -.
DR VGNC; VGNC:34920; SLC6A2.
DR GeneTree; ENSGT00940000158960; -.
DR Proteomes; UP000009136; Chromosome 18.
DR Bgee; ENSBTAG00000003353; Expressed in prostate gland and 53 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1MWL4; baseline and differential.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005328; F:neurotransmitter:sodium symporter activity; IEA:InterPro.
DR InterPro; IPR000175; Na/ntran_symport.
DR InterPro; IPR002435; Na/ntran_symport_noradrenaline.
DR InterPro; IPR037272; SNS_sf.
DR NCBIfam; NF037979; Na_transp; 1.
DR PANTHER; PTHR11616:SF307; SODIUM-DEPENDENT NORADRENALINE TRANSPORTER; 1.
DR PANTHER; PTHR11616; SODIUM/CHLORIDE DEPENDENT TRANSPORTER; 1.
DR Pfam; PF00209; SNF; 1.
DR PRINTS; PR00176; NANEUSMPORT.
DR PRINTS; PR01201; NORTRANSPORT.
DR SUPFAM; SSF161070; SNF-like; 1.
DR PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1.
DR PROSITE; PS00754; NA_NEUROTRAN_SYMP_2; 1.
DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Symport {ECO:0000256|RuleBase:RU003732};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003732};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003732}.
FT TRANSMEM 63..81
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 93..114
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 135..162
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 233..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 260..285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 305..330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 342..367
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 387..413
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 442..467
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 473..496
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 517..538
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 550..573
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 591 AA; 66110 MW; 841884BA4D091A09 CRC64;
MLLARMNPQV QPENGGAGPG SEQPPRKRKE VLVVKERNGV QCLLASRDGD EQPRETWGKK
IDFLLSVVGF AVDLANVWRF PYLCYKNGGG AFLIPYTLFL IIAGMPLFYM ELALGQYNRE
GAATVWKICP FFKGVGYAVI LIALYVGFYY NVIIAWSLYY LFSSFTPTLP WTDCGHAWNS
PNCTDPKLLN SSVLGNHTKY SKYKFTPAAE FYERGVLHLH ESSGIHDIGL PQWQLLLCLI
IVVIVLFFSL WKGVKTSGKV VWITATLPYL VLFVLLVHGI TLPGASNGIN AYLHIDFYRL
KEATVWIDAA TQIFFSLGAG FGVLIAFASY NKFDNNCYRD ALLTSTINCV TSFISGFAIF
SILGYMAHEH KVNIEDVATE GAGLVFILYP EAISTLSGST FWAIVFFIML LALGIDSSMG
GMEAVITGLA DDFQVLKRHR KLFTFAVSFG TFLLALFCIT KGGIYVLTLL DTFAAGTSIL
FAVLMEAIGV SWFYGVDRFS NDIQQMMGFK PGLYWRLCWK FVSPAFLLFV VIVSIINFKP
LTYDDYIFPL WANWVGWGIA GSSMVLVPAY IVYKFFSTRG SIRELQHWLA I
//
